日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Broadly neutralizing antibody PGT121 allosterically modulates CD4 binding via recognition of the HIV-1 gp120 V3 base and multiple surrounding glycans

广谱中和抗体 PGT121 通过识别 HIV-1 gp120 V3 碱基及其周围多个聚糖,变构调节 CD4 结合。

Julien, Jean-Philippe; Sok, Devin; Khayat, Reza; Lee, Jeong Hyun; Doores, Katie J; Walker, Laura M; Ramos, Alejandra; Diwanji, Devan C; Pejchal, Robert; Cupo, Albert; Katpally, Umesh; Depetris, Rafael S; Stanfield, Robyn L; McBride, Ryan; Marozsan, Andre J; Paulson, James C; Sanders, Rogier W; Moore, John P; Burton, Dennis R; Poignard, Pascal; Ward, Andrew B; Wilson, Ian A

Partial enzymatic deglycosylation preserves the structure of cleaved recombinant HIV-1 envelope glycoprotein trimers.

部分酶促去糖基化作用保留了裂解的重组 HIV-1 包膜糖蛋白三聚体的结构

Depetris Rafael S, Julien Jean-Philippe, Khayat Reza, Lee Jeong Hyun, Pejchal Robert, Katpally Umesh, Cocco Nicolette, Kachare Milind, Massi Evan, David Kathryn B, Cupo Albert, Marozsan Andre J, Olson William C, Ward Andrew B, Wilson Ian A, Sanders Rogier W, Moore John P

Trimeric HIV-1 glycoprotein gp140 immunogens and native HIV-1 envelope glycoproteins display the same closed and open quaternary molecular architectures

三聚体 HIV-1 糖蛋白 gp140 免疫原和天然 HIV-1 包膜糖蛋白具有相同的封闭和开放的四级分子结构。

Harris, Audray; Borgnia, Mario J; Shi, Dan; Bartesaghi, Alberto; He, Haifeng; Pejchal, Robert; Kang, Yun Kenneth; Depetris, Rafael; Marozsan, Andre J; Sanders, Rogier W; Klasse, Per Johan; Milne, Jacqueline L S; Wilson, Ian A; Olson, William C; Moore, John P; Subramaniam, Sriram

Structure and function of broadly reactive antibody PG16 reveal an H3 subdomain that mediates potent neutralization of HIV-1

广谱反应性抗体PG16的结构和功能揭示了一个H3亚结构域,该亚结构域介导了对HIV-1的强效中和作用。

Pejchal, Robert; Walker, Laura M; Stanfield, Robyn L; Phogat, Sanjay K; Koff, Wayne C; Poignard, Pascal; Burton, Dennis R; Wilson, Ian A

Metal active site elasticity linked to activation of homocysteine in methionine synthases

金属活性位点弹性与蛋氨酸合成酶中同型半胱氨酸的活化有关

Koutmos, Markos; Pejchal, Robert; Bomer, Theresa M; Matthews, Rowena G; Smith, Janet L; Ludwig, Martha L

Structural perturbations in the Ala --> Val polymorphism of methylenetetrahydrofolate reductase: how binding of folates may protect against inactivation

亚甲基四氢叶酸还原酶Ala→Val多态性的结构扰动:叶酸结合如何保护其免于失活

Pejchal, Robert; Campbell, Elizabeth; Guenther, Brian D; Lennon, Brett W; Matthews, Rowena G; Ludwig, Martha L