日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Identification of novel type 1 and type 2 diabetes genes by co-localization of human islet eQTL and GWAS variants with colocRedRibbon

利用 colocRedRibbon 技术,通过对人类胰岛 eQTL 和 GWAS 变异进行共定位,鉴定新的 1 型和 2 型糖尿病基因。

Piron, Anthony; Szymczak, Florian; Folon, Lise; Crouch, Daniel J M; Papadopoulou, Theodora; Lytrivi, Maria; Tong, Yue; Alvelos, Maria Inês; Colli, Maikel L; Yi, Xiaoyan; Pekalski, Marcin L; Hatzikotoulas, Konstantinos; Huerta-Chagoya, Alicia; Taylor, Henry J; Defrance, Matthieu; Todd, John A; Eizirik, Décio L; Mercader, Josep M; Cnop, Miriam

Antigen receptor stimulation induces purifying selection against pathogenic mitochondrial tRNA mutations

抗原受体刺激诱导针对致病线粒体 tRNA 突变的净化选择

Jingdian Zhang, Camilla Koolmeister, Jinming Han, Roberta Filograna, Leo Hanke, Monika Àdori, Daniel J Sheward, Sina Teifel, Shreekara Gopalakrishna, Qiuya Shao, Yong Liu, Keying Zhu, Robert A Harris, Gerald McInerney, Ben Murrell, Mike Aoun, Liselotte Bäckdahl, Rikard Holmdahl, Marcin Pekalski, Ann

CD56bright natural killer cells preferentially kill proliferating CD4+ T cells

CD56bright 自然杀伤细胞优先杀死增殖的 CD4+ T 细胞

Mercede Lee, Charles J M Bell, Arcadio Rubio Garcia, Leila Godfrey, Marcin Pekalski, Linda S Wicker, John A Todd, Ricardo C Ferreira

Low-dose IL-2 reduces IL-21+ T cell frequency and induces anti-inflammatory gene expression in type 1 diabetes

低剂量 IL-2 降低 IL-21+ T 细胞频率并诱导 1 型糖尿病中的抗炎基因表达

Jia-Yuan Zhang, Fiona Hamey, Dominik Trzupek, Marius Mickunas, Mercede Lee, Leila Godfrey, Jennie H M Yang, Marcin L Pekalski, Jane Kennet, Frank Waldron-Lynch, Mark L Evans, Timothy I M Tree, Linda S Wicker, John A Todd, Ricardo C Ferreira

Thymocyte regulatory variant alters transcription factor binding and protects from type 1 diabetes in infants

胸腺细胞调节变异体改变转录因子结合,并保护婴儿免受1型糖尿病的侵害

Sandholm, Niina; Rubio García, Arcadio; Pekalski, Marcin L; Inshaw, Jamie R J; Cutler, Antony J; Todd, John A

Supplementation with Bifidobacterium longum subspecies infantis EVC001 for mitigation of type 1 diabetes autoimmunity: the GPPAD-SINT1A randomised controlled trial protocol

补充婴儿双歧杆菌 EVC001 以减轻 1 型糖尿病自身免疫:GPPAD-SINT1A 随机对照试验方案

Ziegler, Anette-Gabriele; Arnolds, Stefanie; Kölln, Annika; Achenbach, Peter; Berner, Reinhard; Bonifacio, Ezio; Casteels, Kristina; Elding Larsson, Helena; Gündert, Melanie; Hasford, Joerg; Kordonouri, Olga; Lundgren, Markus; Oltarzewski, Mariusz; Pekalski, Marcin L; Pfirrmann, Markus; Snape, Matthew D; Szypowska, Agnieszka; Todd, John A

Chronic Immune Activation in Systemic Lupus Erythematosus and the Autoimmune PTPN22 Trp620 Risk Allele Drive the Expansion of FOXP3+ Regulatory T Cells and PD-1 Expression

系统性红斑狼疮中的慢性免疫激活和自身免疫性 PTPN22 Trp620 风险等位基因驱动 FOXP3+ 调节性 T 细胞和 PD-1 表达的扩增

Ricardo C Ferreira, Xaquin Castro Dopico, João J Oliveira, Daniel B Rainbow, Jennie H Yang, Dominik Trzupek, Sarah A Todd, Mhairi McNeill, Maristella Steri, Valeria Orrù, Edoardo Fiorillo, Daniel J M Crouch, Marcin L Pekalski, Francesco Cucca, Tim I Tree, Tim J Vyse, Linda S Wicker, John A Todd

A long-lived IL-2 mutein that selectively activates and expands regulatory T cells as a therapy for autoimmune disease

一种长寿命 IL-2 突变蛋白,可选择性激活和扩增调节性 T 细胞,用于治疗自身免疫性疾病

Laurence B Peterson, Charles J M Bell, Sarah K Howlett, Marcin L Pekalski, Kevin Brady, Heather Hinton, Denise Sauter, John A Todd, Pablo Umana, Oliver Ast, Inja Waldhauer, Anne Freimoser-Grundschober, Ekkehard Moessner, Christian Klein, Ralf J Hosse, Linda S Wicker

The DILfrequency study is an adaptive trial to identify optimal IL-2 dosing in patients with type 1 diabetes

DILfrequency 研究是一项适应性试验,旨在确定 1 型糖尿病患者的最佳 IL-2 剂量。

Seelig, Eleonora; Howlett, James; Porter, Linsey; Truman, Lucy; Heywood, James; Kennet, Jane; Arbon, Emma L; Anselmiova, Katerina; Walker, Neil M; Atkar, Ravinder; Pekalski, Marcin L; Rytina, Ed; Evans, Mark; Wicker, Linda S; Todd, John A; Mander, Adrian P; Bond, Simon; Waldron-Lynch, Frank

Cells with Treg-specific FOXP3 demethylation but low CD25 are prevalent in autoimmunity

在自身免疫性疾病中,具有 Treg 特异性 FOXP3 去甲基化但 CD25 水平低的细胞很常见。

Ferreira, Ricardo C; Simons, Henry Z; Thompson, Whitney S; Rainbow, Daniel B; Yang, Xin; Cutler, Antony J; Oliveira, Joao; Castro Dopico, Xaquin; Smyth, Deborah J; Savinykh, Natalia; Mashar, Meghavi; Vyse, Tim J; Dunger, David B; Baxendale, Helen; Chandra, Anita; Wallace, Chris; Todd, John A; Wicker, Linda S; Pekalski, Marcin L