Pekar Lukas相关文献与解析，生知库 | 链接生命科学的每一步

日期影响因子

Antigen-directed single domain antibody-based TNFR1 agonists elicit preferential killing of HER2-overexpressing cancer cells.

抗原导向的单域抗体型 TNFR1 激动剂可优先杀死 HER2 过表达的癌细胞。

期刊:iScience

影响因子:4.1

doi:10.1016/j.isci.2026.115327

Unmuth Laura, Lipinski Britta, Hoerr Alicia, Harwardt Julia, Guarnera Enrico, Szczepek Michal, Becker Stefan, Menrad Andreas, Scheerer Patrick, Evers Andreas, Krah Simon, Elter Desislava, Pekar Lukas, Zielonka Stefan

细胞生物学

发表日期：2026

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Optimizing colloidal stability and viscosity of multispecific antibodies at the drug discovery-development interface: a systematic predictive case study

在药物发现与开发界面优化多特异性抗体的胶体稳定性和粘度：一项系统性预测案例研究

影响因子:7.3

doi:10.1080/19420862.2025.2553622

Siegmund, Vanessa; Klewinghaus, Daniel; Teroerde, Jonas; Pekar, Lukas; Harwardt, Julia; Zielonka, Stefan; Militano, Francesca; Licari, Giuseppe; Evers, Andreas

发表日期：2025

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From discovery to the clinic: structural insights, engineering options, clinical, and 'next wave' applications of camelid-derived single-domain antibodies

从发现到临床：骆驼科动物来源的单域抗体的结构解析、工程改造方案、临床应用及“下一代”应用

影响因子:7.3

doi:10.1080/19420862.2025.2583210

Evers, Andreas; Guarnera, Enrico; Pekar, Lukas; Zielonka, Stefan

发表日期：2025

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Trispecific SEED antibodies engineered for neutrophil-mediated cell killing.

经工程改造的三特异性SEED抗体，用于中性粒细胞介导的细胞杀伤

影响因子:7.3

doi:10.1080/19420862.2025.2532851

Natale Veronica, Heves Gergely, Stadlbauer Katharina, RÃ¼ker Florian, Siegmund Vanessa, Pekar Lukas, Zielonka Stefan, Toleikis Lars, Becker Stefan, Wozniak-Knopp Gordana

细胞生物学

中性粒细胞

发表日期：2025

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Enhancing NK cell-mediated tumor killing of B7-H6(+) cells with bispecific antibodies targeting allosteric sites of NKp30.

利用靶向 NKp30 变构位点的双特异性抗体增强 NK 细胞介导的 B7-H6(+) 细胞的肿瘤杀伤作用

期刊:Molecular Therapy Oncology

影响因子:5.3

doi:10.1016/j.omton.2024.200917

Fournier LÃ©xane, Arras Paul, Pekar Lukas, Kolmar Harald, Zielonka Stefan, Toleikis Lars, Becker Stefan

细胞生物学

发表日期：2025

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AI/ML combined with next-generation sequencing of VHH immune repertoires enables the rapid identification of de novo humanized and sequence-optimized single domain antibodies: a prospective case study

人工智能/机器学习结合新一代测序技术对VHH免疫库进行测序，能够快速鉴定新生的人源化和序列优化的单域抗体：一项前瞻性案例研究

期刊:Frontiers in Molecular Biosciences

doi:10.3389/fmolb.2023.1249247

Arras, Paul; Yoo, Han Byul; Pekar, Lukas; Clarke, Thomas; Friedrich, Lukas; Schröter, Christian; Schanz, Jennifer; Tonillo, Jason; Siegmund, Vanessa; Doerner, Achim; Krah, Simon; Guarnera, Enrico; Zielonka, Stefan; Evers, Andreas

免疫/内分泌

发表日期：2023

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