日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Molecular determinants of antagonist interactions with chemokine receptors CCR2 and CCR5

拮抗剂与趋化因子受体CCR2和CCR5相互作用的分子决定因素

Dawson, John R D; Wadman, Grant M; Zhang, Penglie; Tebben, Andrew; Carter, Percy H; Gu, Siyi; Shroka, Thomas; Borrega-Roman, Leire; Salanga, Catherina L; Handel, Tracy M; Kufareva, Irina

CCX559 is a potent, orally-administered small molecule PD-L1 inhibitor that induces anti-tumor immunity

CCX559是一种强效的口服小分子PD-L1抑制剂,可诱导抗肿瘤免疫。

Kathleen M C Sullivan ,Marta Vilalta ,Linda S Ertl ,Yu Wang ,Carolyn Dunlap ,Karen Ebsworth ,Bin N Zhao ,Shijie Li ,Yibin Zeng ,Zhenhua Miao ,Pingchen Fan ,Venkat Mali ,Christopher Lange ,Darren McMurtrie ,Ju Yang ,Rebecca Lui ,Ryan Scamp ,Vicky Chhina ,Alice Kumamoto ,Simon Yau ,Ton Dang ,Ashton Easterday ,Shirley Liu ,Shichang Miao ,Israel Charo ,Thomas J Schall ,Penglie Zhang

Structures of atypical chemokine receptor 3 reveal the basis for its promiscuity and signaling bias

非典型趋化因子受体 3 的结构揭示了其混杂性和信号偏向性的基础

Yu-Chen Yen, Christopher T Schafer, Martin Gustavsson, Stefanie A Eberle, Pawel K Dominik, Dawid Deneka, Penglie Zhang, Thomas J Schall, Anthony A Kossiakoff, John J G Tesmer, Tracy M Handel

Cancer associated fibroblast FAK regulates malignant cell metabolism

癌症相关成纤维细胞FAK调控恶性细胞代谢

Fevzi Demircioglu ,Jun Wang ,Juliana Candido ,Ana S H Costa ,Pedro Casado ,Beatriz de Luxan Delgado ,Louise E Reynolds ,Jesus Gomez-Escudero ,Emma Newport ,Vinothini Rajeeve ,Ann-Marie Baker ,Marina Roy-Luzarraga ,Trevor A Graham ,Julie Foster ,Yu Wang ,James J Campbell ,Rajinder Singh ,Penglie Zhang ,Thomas J Schall ,Frances R Balkwill ,Jane Sosabowski ,Pedro R Cutillas ,Christian Frezza ,Patricia Sancho ,Kairbaan Hodivala-Dilke

CCR2-Mediated Uptake of Constitutively Produced CCL2: A Mechanism for Regulating Chemokine Levels in the Blood

CCR2 介导的组成性 CCL2 摄取:一种调节血液中趋化因子水平的机制

Bin N Zhao, James J Campbell, Catherina L Salanga, Linda S Ertl, Yu Wang, Simon Yau, Ton Dang, Yibin Zeng, Jeffrey P McMahon, Antoni Krasinski, Penglie Zhang, Irina Kufareva, Tracy M Handel, Israel F Charo, Rajinder Singh, Thomas J Schall

Enzalutamide and CXCR7 inhibitor combination treatment suppresses cell growth and angiogenic signaling in castration-resistant prostate cancer models

恩杂鲁胺和 CXCR7 抑制剂联合治疗可抑制去势抵抗性前列腺癌模型中的细胞生长和血管生成信号

Yong Luo, Abul Kalam Azad, Styliani Karanika, Spyridon P Basourakos, Xuemei Zuo, Jianxiang Wang, Luan Yang, Guang Yang, Dimitrios Korentzelos, Jianhua Yin, Sanghee Park, Penglie Zhang, James J Campbell, Thomas J Schall, Guangwen Cao, Likun Li, Timothy C Thompson

CC chemokine receptor 2 promotes recruitment of myeloid cells associated with insulin resistance in nonalcoholic fatty liver disease

CC 趋化因子受体 2 促进非酒精性脂肪肝中与胰岛素抵抗相关的髓系细胞募集

Richard Parker, Christopher J Weston, Zhenhua Miao, Christopher Corbett, Matthew J Armstrong, Linda Ertl, Karen Ebsworth, Matthew J Walters, Trageen Baumart, Dale Newland, Jeff McMahon, Penglie Zhang, Rajinder Singh, James Campbell, Philip N Newsome, Israel Charo, Thomas J Schall, David H Adams

CCR2 antagonism leads to marked reduction in proteinuria and glomerular injury in murine models of focal segmental glomerulosclerosis (FSGS)

CCR2 拮抗剂可显著减少局灶节段性肾小球硬化 (FSGS) 小鼠模型中的蛋白尿和肾小球损伤

Zhenhua Miao, Linda S Ertl, Dale Newland, Bin Zhao, Yu Wang, Xiaoping Zang, James J Campbell, Xiaoli Liu, Ton Dang, Shichang Miao, Antoni Krasinski, Sreenivas Punna, Yibin Zeng, Jeffrey McMahon, Penglie Zhang, Israel F Charo, Thomas J Schall, Rajinder Singh

Structural basis of ligand interaction with atypical chemokine receptor 3

配体与非典型趋化因子受体 3 相互作用的结构基础

Martin Gustavsson, Liwen Wang, Noortje van Gils, Bryan S Stephens, Penglie Zhang, Thomas J Schall, Sichun Yang, Ruben Abagyan, Mark R Chance, Irina Kufareva, Tracy M Handel

Characterization of Pharmacologic and Pharmacokinetic Properties of CCX168, a Potent and Selective Orally Administered Complement 5a Receptor Inhibitor, Based on Preclinical Evaluation and Randomized Phase 1 Clinical Study.

基于临床前评价和随机 1 期临床研究,对强效选择性口服补体 5a 受体抑制剂 CCX168 的药理学和药代动力学特性进行表征

Bekker Pirow, Dairaghi Daniel, Seitz Lisa, Leleti Manmohan, Wang Yu, Ertl Linda, Baumgart Trageen, Shugarts Sarah, Lohr Lisa, Dang Ton, Miao Shichang, Zeng Yibin, Fan Pingchen, Zhang Penglie, Johnson Daniel, Powers Jay, Jaen Juan, Charo Israel, Schall Thomas J