Penketh Philip G相关文献与解析，生知库 | 链接生命科学的每一步

pH-dependent general base catalyzed activation rather than isocyanate liberation may explain the superior anticancer efficacy of laromustine compared to related 1,2-bis(methylsulfonyl)-1-(2-chloroethyl)hydrazine prodrugs

与相关的 1,2-双(甲基磺酰基)-1-(2-氯乙基)肼前药相比，拉罗莫司汀的抗癌疗效更佳，这可能是由于 pH 依赖性一般碱催化活化而非异氰酸酯释放所致。

期刊:

影响因子:

doi:10.1111/cbdd.13057

Penketh, Philip G; Finch, Richard A; Sauro, Rachel; Baumann, Raymond P; Ratner, Elena S; Shyam, Krishnamurthy

When alcohol is the answer: Trapping, identifying and quantifying simple alkylating species in aqueous environments

当酒精成为答案时：在水溶液环境中捕获、识别和定量简单的烷基化物质

期刊:Analytical Biochemistry

影响因子:2.5

doi:10.1016/j.ab.2016.04.020

Penketh, Philip G; Shyam, Krishnamurthy; Baumann, Raymond P; Zhu, Rui; Ishiguro, Kimiko; Sartorelli, Alan C; Ratner, Elena S

发表日期：2016

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Influence of phosphate and phosphoesters on the decomposition pathway of 1,2-bis(methylsulfonyl)-1-(2-chloroethyhydrazine (90CE), the active anticancer moiety generated by Laromustine, KS119, and KS119W

磷酸盐和磷酸酯对拉罗莫司汀、KS119 和 KS119W 产生的活性抗癌成分 1,2-双(甲磺酰基)-1-(2-氯乙基肼) (90CE) 分解途径的影响

期刊:Chemical Research in Toxicology

影响因子:3.8

doi:10.1021/tx500004y

Penketh, Philip G; Shyam, Krishnamurthy; Zhu, Rui; Baumann, Raymond P; Ishiguro, Kimiko; Sartorelli, Alan C

Hypoxia-selective O6-alkylguanine-DNA alkyltransferase inhibitors: design, synthesis, and evaluation of 6-(benzyloxy)-2-(aryldiazenyl)-9H-purines as prodrugs of O6-benzylguanine.

低氧选择性 O6-烷基鸟嘌呤-DNA 烷基转移酶抑制剂：6-(苄氧基)-2-(芳基重氮基)-9H-嘌呤作为 O6-苄基鸟嘌呤前药的设计、合成和评价

期刊:Journal of Medicinal Chemistry

影响因子:6.8

doi:10.1021/jm301804p

Zhu Rui, Baumann Raymond P, Penketh Philip G, Shyam Krishnamurthy, Sartorelli Alan C

信号转导

发表日期：2013

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Chloroethylating and methylating dual function antineoplastic agents display superior cytotoxicity against repair proficient tumor cells

氯乙基化和甲基化双功能抗肿瘤药物对具有修复能力的肿瘤细胞表现出优异的细胞毒性。

期刊:Bioorganic & Medicinal Chemistry Letters

影响因子:2.2

doi:10.1016/j.bmcl.2013.01.016

Zhu, Rui; Baumann, Raymond P; Patridge, Eric; Penketh, Philip G; Shyam, Krishnamurthy; Ishiguro, Kimiko; Sartorelli, Alan C

7-Nitro-4-(phenylthio)benzofurazan is a potent generator of superoxide and hydrogen peroxide

7-硝基-4-(苯硫基)苯并呋喃是一种强效的超氧化物和过氧化氢生成剂。

期刊:Archives of Toxicology

影响因子:6.9

doi:10.1007/s00204-012-0872-9

Patridge, Eric V; Eriksson, Emma S E; Penketh, Philip G; Baumann, Raymond P; Zhu, Rui; Shyam, Krishnamurthy; Eriksson, Leif A; Sartorelli, Alan C

发表日期：2012

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A strategy for selective O(6)-alkylguanine-DNA alkyltransferase depletion under hypoxic conditions.

在缺氧条件下选择性耗竭 O(6)-烷基鸟嘌呤-DNA 烷基转移酶的策略

期刊:Chemical Biology & Drug Design

影响因子:3.3

doi:10.1111/j.1747-0285.2012.01401.x

Penketh Philip G, Shyam Krishnamurthy, Baumann Raymond P, Ishiguro Kimiko, Patridge Eric V, Zhu Rui, Sartorelli Alan C

免疫/内分泌

发表日期：2012

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Design of a hypoxia-activated prodrug inhibitor of O6-alkylguanine-DNA alkyltransferase

设计一种缺氧激活的O6-烷基鸟嘌呤-DNA烷基转移酶前药抑制剂

期刊:Bioorganic & Medicinal Chemistry Letters

影响因子:2.2

doi:10.1016/j.bmcl.2012.08.008

Zhu, Rui; Seow, Helen A; Baumann, Raymond P; Ishiguro, Kimiko; Penketh, Philip G; Shyam, Krishnamurthy; Sartorelli, Alan C

发表日期：2012

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KS900: A hypoxia-directed, reductively activated methylating antitumor prodrug that selectively ablates O(6)-alkylguanine-DNA alkyltransferase in neoplastic cells.

KS900：一种缺氧导向的还原激活甲基化抗肿瘤前药，可选择性地消除肿瘤细胞中的 O(6)-烷基鸟嘌呤-DNA 烷基转移酶

期刊:Biochemical Pharmacology

影响因子:5.6

doi:10.1016/j.bcp.2011.02.019

Baumann Raymond P, Ishiguro Kimiko, Penketh Philip G, Shyam Krishnamurthy, Zhu Rui, Sartorelli Alan C

肿瘤

发表日期：2011

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First person to Watch – E. Jennifer Jin, Seungmee Park and Xiaohui Lyu

首位值得关注的人物——E. Jennifer Jin、Seungmee Park 和 Xiaohui Lyu

pH-dependent general base catalyzed activation rather than isocyanate liberation may explain the superior anticancer efficacy of laromustine compared to related 1,2-bis(methylsulfonyl)-1-(2-chloroethyl)hydrazine prodrugs

与相关的 1,2-双(甲基磺酰基)-1-(2-氯乙基)肼前药相比，拉罗莫司汀的抗癌疗效更佳，这可能是由于 pH 依赖性一般碱催化活化而非异氰酸酯释放所致。

When alcohol is the answer: Trapping, identifying and quantifying simple alkylating species in aqueous environments

当酒精成为答案时：在水溶液环境中捕获、识别和定量简单的烷基化物质

Influence of phosphate and phosphoesters on the decomposition pathway of 1,2-bis(methylsulfonyl)-1-(2-chloroethyhydrazine (90CE), the active anticancer moiety generated by Laromustine, KS119, and KS119W

磷酸盐和磷酸酯对拉罗莫司汀、KS119 和 KS119W 产生的活性抗癌成分 1,2-双(甲磺酰基)-1-(2-氯乙基肼) (90CE) 分解途径的影响

Hypoxia-selective O6-alkylguanine-DNA alkyltransferase inhibitors: design, synthesis, and evaluation of 6-(benzyloxy)-2-(aryldiazenyl)-9H-purines as prodrugs of O6-benzylguanine.

低氧选择性 O6-烷基鸟嘌呤-DNA 烷基转移酶抑制剂：6-(苄氧基)-2-(芳基重氮基)-9H-嘌呤作为 O6-苄基鸟嘌呤前药的设计、合成和评价

Chloroethylating and methylating dual function antineoplastic agents display superior cytotoxicity against repair proficient tumor cells

氯乙基化和甲基化双功能抗肿瘤药物对具有修复能力的肿瘤细胞表现出优异的细胞毒性。

7-Nitro-4-(phenylthio)benzofurazan is a potent generator of superoxide and hydrogen peroxide

7-硝基-4-(苯硫基)苯并呋喃是一种强效的超氧化物和过氧化氢生成剂。

A strategy for selective O(6)-alkylguanine-DNA alkyltransferase depletion under hypoxic conditions.

在缺氧条件下选择性耗竭 O(6)-烷基鸟嘌呤-DNA 烷基转移酶的策略

Design of a hypoxia-activated prodrug inhibitor of O6-alkylguanine-DNA alkyltransferase

设计一种缺氧激活的O6-烷基鸟嘌呤-DNA烷基转移酶前药抑制剂

KS900: A hypoxia-directed, reductively activated methylating antitumor prodrug that selectively ablates O(6)-alkylguanine-DNA alkyltransferase in neoplastic cells.

KS900：一种缺氧导向的还原激活甲基化抗肿瘤前药，可选择性地消除肿瘤细胞中的 O(6)-烷基鸟嘌呤-DNA 烷基转移酶