Penrose Harrison相关文献与解析，生知库 | 链接生命科学的每一步

A Living Organoid Biobank of Crohn's Disease Patients Reveals Distinct Clinical Correlates of Molecular Disease Subtypes

克罗恩病患者的活体类器官生物样本库揭示了分子疾病亚型的独特临床相关性

doi:10.1101/2025.04.01.25325058

Penrose, Harrison M; Sinha, Saptarshi; Tindle, Courtney; Zablan, Kameron; Le, Helen N; Neill, Jennifer; Ghosh, Pradipta; Boland, Brigid S

F.O.R.W.A.R.D: A Data-Driven Framework for Network-Based Target Prioritization in Drug Discovery

FORWARD：一种基于网络的药物发现靶点优先级排序的数据驱动框架

期刊:

影响因子:

doi:10.1101/2024.07.16.602603

Sinha, Saptarshi; McLaren, Ella; Mullick, Madhubanti; Penrose, Harrison M; Tindle, Courtney; Singh, Siddharth; Boland, Brigid S; Ghosh, Pradipta

发表日期：2025

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The ClC-2 Chloride Channel Activator, Lubiprostone, Improves Intestinal Barrier Function in Biopsies from Crohn's Disease but Not Ulcerative Colitis Patients

ClC-2氯离子通道激活剂鲁比前列酮可改善克罗恩病患者肠道活检样本中的肠道屏障功能，但对溃疡性结肠炎患者无效。

期刊:Pharmaceutics

影响因子:5.5

doi:10.3390/pharmaceutics15030811

Park, Young Su; Kang, Sang Bum; Marchelletta, Ronald R; Penrose, Harrison M; Ruiter-Visser, Roos; Jung, Barbara; Docherty, Michael J; Boland, Brigid S; Sandborn, William J; McCole, Declan F

FOXO3 Deficiency in Neutrophils Drives Colonic Inflammation and Tumorigenesis.

中性粒细胞中 FOXO3 缺乏会引发结肠炎症和肿瘤发生

期刊:International Journal of Molecular Sciences

影响因子:4.9

doi:10.3390/ijms24119730

Ghimire Jenisha, Iftikhar Rida, Penrose Harrison M, Snarski Patricia, Ruiz Emmanuelle, Savkovic Suzana D

Correction: Elevated ATGL in colon cancer cells and cancer stem cells promotes metabolic and tumorigenic reprogramming reinforced by obesity

更正：结肠癌细胞和癌干细胞中ATGL水平升高会促进代谢和肿瘤发生重编程，而肥胖会加剧这一过程。

期刊:Oncogenesis

影响因子:6.4

doi:10.1038/s41389-022-00388-5

Iftikhar, Rida; Penrose, Harrison M; King, Angelle N; Samudre, Joshua S; Collins, Morgan E; Hartono, Alifiani B; Lee, Sean B; Lau, Frank; Baddoo, Melody; Flemington, Erik F; Crawford, Susan E; Savkovic, Suzana D

FOXO3 Expression in Macrophages Is Lowered by a High-Fat Diet and Regulates Colonic Inflammation and Tumorigenesis

高脂饮食会降低巨噬细胞中FOXO3的表达，而FOXO3调控结肠炎症和肿瘤发生

期刊:Metabolites

影响因子:3.7

doi:10.3390/metabo12030250

Iftikhar, Rida; Penrose, Harrison M; King, Angelle N; Kim, Yunah; Ruiz, Emmanuelle; Kandil, Emad; Machado, Heather L; Savkovic, Suzana D

Immunology/Inflammation

Trends in the Incidence of Early-Onset Colorectal Adenocarcinoma Among Black and White US Residents Aged 40 to 49 Years, 2000-2017

2000-2017年美国40至49岁黑人和白人居民早发性结直肠腺癌发病率趋势

期刊:Jama Network Open

影响因子:9.7

doi:10.1001/jamanetworkopen.2021.30433

Montminy, Eric M; Zhou, Meijiao; Maniscalco, Lauren; Penrose, Harrison; Yen, Timothy; Patel, Swati G; Wu, Xiao-Cheng; Karlitz, Jordan J

Elevated ATGL in colon cancer cells and cancer stem cells promotes metabolic and tumorigenic reprogramming reinforced by obesity.

结肠癌细胞和癌症干细胞中 ATGL 水平升高会促进代谢和肿瘤发生重编程，而肥胖会加剧这种重编程

期刊:Oncogenesis

影响因子:6.4

doi:10.1038/s41389-021-00373-4

Iftikhar Rida, Penrose Harrison M, King Angelle N, Samudre Joshua S, Collins Morgan E, Hartono Alifiani B, Lee Sean B, Lau Frank, Baddoo Melody, Flemington Erik F, Crawford Susan E, Savkovic Suzana D

Ulcerative colitis immune cell landscapes and differentially expressed gene signatures determine novel regulators and predict clinical response to biologic therapy

溃疡性结肠炎免疫细胞图谱和差异表达基因特征决定了新的调控因子并预测了生物疗法的临床疗效

期刊:Scientific Reports

影响因子:3.9

doi:10.1038/s41598-021-88489-w

Penrose, Harrison M; Iftikhar, Rida; Collins, Morgan E; Toraih, Eman; Ruiz, Emmanuelle; Ungerleider, Nathan; Nakhoul, Hani; Flemington, Erik F; Kandil, Emad; Shah, Shamita B; Savkovic, Suzana D

New approach methodologies in Crohn's disease link molecular disease subtypes to clinical outcomes

克罗恩病的新方法将分子疾病亚型与临床结果联系起来

A Living Organoid Biobank of Crohn's Disease Patients Reveals Distinct Clinical Correlates of Molecular Disease Subtypes

克罗恩病患者的活体类器官生物样本库揭示了分子疾病亚型的独特临床相关性

F.O.R.W.A.R.D: A Data-Driven Framework for Network-Based Target Prioritization in Drug Discovery

FORWARD：一种基于网络的药物发现靶点优先级排序的数据驱动框架

The ClC-2 Chloride Channel Activator, Lubiprostone, Improves Intestinal Barrier Function in Biopsies from Crohn's Disease but Not Ulcerative Colitis Patients

ClC-2氯离子通道激活剂鲁比前列酮可改善克罗恩病患者肠道活检样本中的肠道屏障功能，但对溃疡性结肠炎患者无效。

FOXO3 Deficiency in Neutrophils Drives Colonic Inflammation and Tumorigenesis.

中性粒细胞中 FOXO3 缺乏会引发结肠炎症和肿瘤发生

Correction: Elevated ATGL in colon cancer cells and cancer stem cells promotes metabolic and tumorigenic reprogramming reinforced by obesity

更正：结肠癌细胞和癌干细胞中ATGL水平升高会促进代谢和肿瘤发生重编程，而肥胖会加剧这一过程。

FOXO3 Expression in Macrophages Is Lowered by a High-Fat Diet and Regulates Colonic Inflammation and Tumorigenesis

高脂饮食会降低巨噬细胞中FOXO3的表达，而FOXO3调控结肠炎症和肿瘤发生

Trends in the Incidence of Early-Onset Colorectal Adenocarcinoma Among Black and White US Residents Aged 40 to 49 Years, 2000-2017

2000-2017年美国40至49岁黑人和白人居民早发性结直肠腺癌发病率趋势

Elevated ATGL in colon cancer cells and cancer stem cells promotes metabolic and tumorigenic reprogramming reinforced by obesity.

结肠癌细胞和癌症干细胞中 ATGL 水平升高会促进代谢和肿瘤发生重编程，而肥胖会加剧这种重编程

Ulcerative colitis immune cell landscapes and differentially expressed gene signatures determine novel regulators and predict clinical response to biologic therapy

溃疡性结肠炎免疫细胞图谱和差异表达基因特征决定了新的调控因子并预测了生物疗法的临床疗效