Sustained activation of XBP1 splicing leads to endothelial apoptosis and atherosclerosis development in response to disturbed flow
XBP1剪接的持续激活会导致内皮细胞凋亡和动脉粥样硬化的发生,以应对紊乱血流。
期刊:Proceedings of the National Academy of Sciences of the United States of America
影响因子:9.1
doi:10.1073/pnas.0903197106
Zeng, Lingfang; Zampetaki, Anna; Margariti, Andriana; Pepe, Anna Elena; Alam, Saydul; Martin, Daniel; Xiao, Qingzhong; Wang, Wen; Jin, Zheng-Gen; Cockerill, Gillian; Mori, Kazutoshi; Li, Yi-Shuan Julie; Hu, Yanhua; Chien, Shu; Xu, Qingbo
凋亡
表观遗传
心血管
XBP1
内皮细胞
细胞生物学
动脉粥样硬化