日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Balancing brain exposure, pharmacokinetics and safety of transferrin receptor antibodies for delivery of neuro-therapeutics

平衡转铁蛋白受体抗体在神经治疗药物递送中的脑暴露、药代动力学和安全性

Smith, Benjamin A; Meeks, Caitlin B; Murray-Brown, Isabel; McCarthy, Elizabeth A; Julian, Mark C; Arndt, Joe; Stewart, Matthew; Spilker, Kerri; D'Lima, Nadia; Dolnikova, Jana; Li, You; Prasad, Shikha; Qian, Fang; Gong, BangJian; Jiang, Di; Yuan, Long; Tuczkewycz, Taras; Amatucci, Joseph; Doyle, Rachel; Wagatsuma, Akiko; Yang, Fu-Chia; Pepinsky, Blake; Weinreb, Paul H; Cameron, Thomas O; Koksal, Adem C

Information From Same-Race/Ethnicity Experts Online Does Not Increase Vaccine Interest or Intention to Vaccinate

来自同种族/族裔专家的在线信息并不会增加人们对疫苗的兴趣或接种意愿。

Gadarian, Shana Kushner; Goodman, Sara Wallace; Michener, Jamila; Nyhan, Brendan; Pepinsky, Thomas B

The anti-Müllerian hormone prodomain is displaced from the hormone/prodomain complex upon bivalent binding to the hormone receptor

抗苗勒氏管激素前结构域与激素受体二价结合后,从激素/前结构域复合物中移出

Richard L Cate, Nathalie di Clemente, Chrystèle Racine, Nigel P Groome, R Blake Pepinsky, Adrian Whitty

Functional activity of anti-LINGO-1 antibody opicinumab requires target engagement at a secondary binding site

抗LINGO-1抗体opicinumab的功能活性需要其与二级结合位点的靶标结合。

Karl J M Hanf ,Joseph W Arndt ,YuTing Liu ,Bang Jian Gong ,Mia Rushe ,Richelle Sopko ,Ramiro Massol ,Benjamin Smith ,Yan Gao ,Isin Dalkilic-Liddle ,Xinhua Lee ,Shanell Mojta ,Zhaohui Shao ,Sha Mi ,R Blake Pepinsky

Monoclonal antibody exposure in rat and cynomolgus monkey cerebrospinal fluid following systemic administration

全身给药后大鼠和猕猴脑脊液中单克隆抗体的暴露情况

Qin Wang, Luisette Delva, Paul H Weinreb, Robert B Pepinsky, Danielle Graham, Elvana Veizaj, Anne E Cheung, Weiping Chen, Ivan Nestorov, Ellen Rohde, Robin Caputo, Geoffrey M Kuesters, Tonika Bohnert, Liang-Shang Gan

Structural and kinetic basis for the selectivity of aducanumab for aggregated forms of amyloid-β

Aducanumab 对聚集形式的淀粉样β蛋白的选择性的结构和动力学基础

Joseph W Arndt, Fang Qian, Benjamin A Smith, Chao Quan, Krishna Praneeth Kilambi, Martin W Bush, Thomas Walz, R Blake Pepinsky, Thierry Bussière, Stefan Hamann, Thomas O Cameron, Paul H Weinreb

LINGO-1 Regulates Oligodendrocyte Differentiation through the Cytoplasmic Gelsolin Signaling Pathway

LINGO-1 通过细胞质凝溶胶蛋白信号通路调节少突胶质细胞分化

Zhaohui Shao, Xinhua Lee, Guanrong Huang, Guoqing Sheng, Christopher E Henderson, Daniel Louvard, Jiho Sohn, Blake Pepinsky, Sha Mi

LINGO-1 Regulates Oligodendrocyte Differentiation through the Cytoplasmic Gelsolin Signaling Pathway

LINGO-1通过胞质凝溶胶蛋白信号通路调控少突胶质细胞分化

Zhaohui Shao,Xinhua Lee,Guanrong Huang,Guoqing Sheng,Christopher E Henderson,Daniel Louvard,Jiho Sohn,Blake Pepinsky,Sha Mi

Engineering potent long-acting variants of the Wnt inhibitor DKK2

设计 Wnt 抑制剂 DKK2 的强效长效变体

Richelle Sopko, Joshua W Mugford, Andreas Lehmann, Renée I Shapiro, Mia Rushe, Abhishek Kulkarni, Joseph Worrall, Joseph Amatucci, Dingyi Wen, Nels E Pederson, Brenda K Minesinger, Joseph W Arndt, Blake Pepinsky

A DR6/p75(NTR) complex is responsible for β-amyloid-induced cortical neuron death

DR6/p75(NTR) 复合物是 β-淀粉样蛋白诱导的皮质神经元死亡的原因

Y Hu, X Lee, Z Shao, D Apicco, G Huang, B J Gong, R B Pepinsky, S Mi