In a Rat Model of Opioid Maintenance, the G Protein-Biased Mu Opioid Receptor Agonist TRV130 Decreases Relapse to Oxycodone Seeking and Taking and Prevents Oxycodone-Induced Brain Hypoxia
在阿片类药物维持治疗的大鼠模型中,G蛋白偏向性μ阿片受体激动剂TRV130可降低对羟考酮的渴求和服用复发率,并预防羟考酮诱导的脑缺氧。
期刊:Biological Psychiatry
影响因子:9
doi:10.1016/j.biopsych.2020.02.014
Bossert, Jennifer M; Kiyatkin, Eugene A; Korah, Hannah; Hoots, Jennifer K; Afzal, Anum; Perekopskiy, David; Thomas, Shruthi; Fredriksson, Ida; Blough, Bruce E; Negus, S Stevens; Epstein, David H; Shaham, Yavin