日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

Validating Natural Compounds as Toll-Like Receptor 4 (TLR4) Antagonists: Experimental Challenges and Therapeutic Perspectives

验证天然化合物作为 Toll 样受体 4 (TLR4) 拮抗剂的有效性：实验挑战和治疗前景

期刊:Journal of Medicinal Chemistry
影响因子:6.8
doi:10.1021/acs.jmedchem.5c02252
Lami, Federico; Romerio, Alessio; Valle-Gómez, Laura; Martín-Cámara, Olmo; Martín-Santamaría, Sonsoles; Peri, Francesco
信号转导
TLR4
Toll-Like Receptor
发表日期：2026
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Monosaccharide-Based Synthetic TLR4 Agonist Enhances Vaccine Efficacy against Pseudomonas aeruginosa Challenge

基于单糖的合成TLR4激动剂可增强疫苗对铜绿假单胞菌感染的效力

期刊:ACS Infectious Diseases
影响因子:3.8
doi:10.1021/acsinfecdis.4c00932
Sainz-Mejías, Maite; Ma, Chaoying; Hou, Yueran; Jurado-Martin, Irene; Romerio, Alessio; Franco, Ana Rita; Shaik, Mohammed Monsoor; Tomás-Cortázar, Julen; Peri, Francesco; McClean, Siobhán
TLR4
炎症/感染
发表日期：2025
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Towards more efficient synthetic immunomodulators: biological characterization and mechanism of action of monosaccharide-derived TLR4 agonists.

迈向更高效的合成免疫调节剂：单糖衍生的 TLR4 激动剂的生物学特性和作用机制

期刊:RSC Medicinal Chemistry
影响因子:3.6
doi:10.1039/d4md00950a
Franco Ana Rita, Aladailleh Zaineh, Romerio Alessio, Italia Alice, Lami Federico, Shaik Mohammed Monsoor, Skupinska Natalia, Artusa Valentina, Pirianov Grisha, Peri Francesco
免疫/内分泌
发表日期：2025
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Preclinical development of the TLR4 antagonist FP12 as a drug lead targeting the HMGB1/MD-2/TLR4 axis in lethal influenza infection

TLR4拮抗剂FP12作为靶向HMGB1/MD-2/TLR4轴治疗致命性流感感染的先导药物，正在进行临床前开发。

期刊:Innate Immunity
影响因子:2.8
doi:10.1177/17534259241313201
Shirey, Kari Ann; Romerio, Alessio; Shaik, Mohammed Monsoor; Leake, David S; Palmer, Charys; Skupinska, Natalia; Paton, Jules; Pirianov, Grisha; Blanco, Jorge Cg; Vogel, Stefanie N; Peri, Francesco
炎症/感染
流感
微生物学
TLR4
HMGB1
发表日期：2025
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Selective SERCA2a activator as a candidate for chronic heart failure therapy

选择性SERCA2a激活剂作为慢性心力衰竭治疗的候选药物

期刊:Journal of Translational Medicine
影响因子:7.5
doi:10.1186/s12967-024-04874-9
Arici, Martina; Hsu, Shih-Che; Ferrandi, Mara; Barassi, Paolo; Ronchi, Carlotta; Torre, Eleonora; Luraghi, Andrea; Chang, Gwo-Jyh; Ferrari, Patrizia; Bianchi, Giuseppe; Peri, Francesco; Zaza, Antonio; Rocchetti, Marcella
心力衰竭
心血管
发表日期：2024
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Development of a New Vaccine Adjuvant System Based on the Combination of the Synthetic TLR4 Agonist FP20 and a Synthetic QS-21 Variant

基于合成TLR4激动剂FP20和合成QS-21变体的组合开发一种新型疫苗佐剂系统

期刊:Journal of Medicinal Chemistry
影响因子:6.8
doi:10.1021/acs.jmedchem.4c02392
Shaik, Mohammed Monsoor; Pasco, Samuel; Romerio, Alessio; Pifferi, Carlo; Sesana, Silvia; Re, Francesca; Bezuidenhout, Charl Xavier; Bracco, Silvia; Fernandez-Tejada, Alberto; Anguita, Juan; Peri, Francesco
TLR4
发表日期：2024
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A small-molecule TLR4 antagonist reduced neuroinflammation in female E4FAD mice

一种小分子TLR4拮抗剂可减轻雌性E4FAD小鼠的神经炎症。

期刊:Alzheimers Research & Therapy
影响因子:7.6
doi:10.1186/s13195-023-01330-6
Balu, Deebika; Valencia-Olvera, Ana C; Nguyen, Austin; Patnam, Mehul; York, Jason; Peri, Francesco; Neumann, Frank; LaDu, Mary Jo; Tai, Leon M
炎症
炎症/感染
神经科学
TLR4
神经炎症
发表日期：2023
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Microbiota-Derived Natural Products Targeting Cancer Stem Cells: Inside the Gut Pharma Factory

肠道菌群衍生的天然产物靶向癌症干细胞：肠道制药工厂内部探秘

期刊:International Journal of Molecular Sciences
影响因子:4.9
doi:10.3390/ijms24054997
Artusa, Valentina; Calabrone, Luana; Mortara, Lorenzo; Peri, Francesco; Bruno, Antonino
肿瘤
肿瘤免疫
细胞生物学
微生物学
肠道菌群
干细胞
发育与干细胞
发表日期：2023
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Emerging Extracellular Molecular Targets for Innovative Pharmacological Approaches to Resistant Mtb Infection

针对耐药结核分枝杆菌感染的创新药理学方法：新兴的细胞外分子靶点

期刊:Biomolecules
影响因子:4.8
doi:10.3390/biom13060999
Italia, Alice; Shaik, Mohammed Monsoor; Peri, Francesco
炎症/感染
细胞生物学
发表日期：2023
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Overcoming Challenges in Chemical Glycosylation to Achieve Innovative Vaccine Adjuvants Possessing Enhanced TLR4 Activity

克服化学糖基化难题，获得具有增强的TLR4活性的创新型疫苗佐剂

期刊:ACS Omega
影响因子:4.3
doi:10.1021/acsomega.3c05363
Romerio, Alessio; Franco, Ana Rita; Shadrick, Melanie; Shaik, Mohammed Monsoor; Artusa, Valentina; Italia, Alice; Lami, Federico; Demchenko, Alexei V; Peri, Francesco
TLR4
发表日期：2023
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