日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Increased TMEM106B levels lead to lysosomal dysfunction which affects synaptic signaling and neuronal health.

TMEM106B 水平升高会导致溶酶体功能障碍,从而影响突触信号传导和神经元健康

Perneel Jolien, Lastra Osua Miranda, Alidadiani Sara, Peeters Nele, De Witte Linus, Heeman Bavo, Manzella Simona, De Rycke Riet, Brooks Mieu, Perkerson Ralph B, Calus Elke, De Coster Wouter, Neumann Manuela, Mackenzie Ian R A, Van Dam Debby, Asselbergh Bob, Ellender Tommas, Zhou Xiaolai, Rademakers Rosa

Neuronal ABCA7 deficiency aggravates mitochondrial dysfunction and neurodegeneration in Alzheimer's disease

神经元ABCA7缺乏会加剧阿尔茨海默病中的线粒体功能障碍和神经退行性变

Ni Wang ,Yining Pan ,Skylar C Starling ,Devon H Haskell ,Astrid C Quintero ,Keiji Kawatani ,Yasuteru Inoue ,Francis Shue ,Xiaoye Ma ,Tomonori Aikawa ,Yuka A Martens ,Aishe Kurti ,Tammee M Parsons ,Ralph B Perkerson ,Bhaskar Roy ,Ana-Caroline Raulin ,Yingxue Ren ,Michael DeTure ,Dennis W Dickson ,Hanmei Bao ,Xianlin Han ,Guojun Bu ,Takahisa Kanekiyo

Alzheimer's disease risk ABCA7 p.A696S variant disturbs the microglial response to amyloid pathology in mice

阿尔茨海默病风险基因ABCA7 p.A696S变异会干扰小鼠小胶质细胞对淀粉样蛋白病理的反应。

Xiaoye Ma ,Dmitry Prokopenko ,Ni Wang ,Tomonori Aikawa ,Younjung Choi ,Can Zhang ,Dan Lei ,Yingxue Ren ,Keiji Kawatani ,Skylar C Starling ,Ralph B Perkerson ,Bhaskar Roy ,Astrid C Quintero ,Tammee M Parsons ,Yining Pan ,Zonghua Li ,Minghui Wang ,Hanmei Bao ,Xianlin Han ,Guojun Bu ,Rudolph E Tanzi ,Takahisa Kanekiyo

Human iPSC-Derived MSCs Induce Neurotrophic Effects and Improve Metabolic Activity in Acute Neuronal Injury Models

人类 iPSC 衍生的 MSC 可在急性神经元损伤模型中诱导神经营养作用并改善代谢活性

Keiji Kawatani, Genesis Omana Suarez, Ralph B Perkerson 3rd, Ephraim E Parent, Toshihiko Nambara, Joshua A Knight, Tammee M Parsons, Kshama Gupta, Francis Shue, Alla Alnobani, Prasanna Vibhute, Hancheng Cai, Hugo Guerrero-Cázares, John A Copland 3rd, Alfredo Quiñones-Hinojosa, Takahisa Kanekiyo

ABCA7 deficiency causes neuronal dysregulation by altering mitochondrial lipid metabolism

ABCA7 缺乏通过改变线粒体脂质代谢导致神经元失调

Keiji Kawatani #, Marie-Louise Holm #, Skylar C Starling, Yuka A Martens, Jing Zhao, Wenyan Lu, Yingxue Ren, Zonghua Li, Peizhou Jiang, Yangying Jiang, Samantha K Baker, Ni Wang, Bhaskar Roy, Tammee M Parsons, Ralph B Perkerson 3rd, Hanmei Bao, Xianlin Han, Guojun Bu, Takahisa Kanekiyo

Secretome from iPSC-derived MSCs exerts proangiogenic and immunosuppressive effects to alleviate radiation-induced vascular endothelial cell damage

来自 iPSC 衍生 MSC 的分泌蛋白组发挥促血管生成和免疫抑制作用,以减轻辐射引起的血管内皮细胞损伤

Kshama Gupta, Ralph B Perkerson 3rd, Tammee M Parsons, Ramacharan Angom, Danilyn Amerna, Jeremy D Burgess, Yingxue Ren, Pamela J McLean, Debabrata Mukhopadhyay, Prasanna Vibhute, Zbigniew K Wszolek, Abba C Zubair, Alfredo Quiñones-Hinojosa, Takahisa Kanekiyo

A mutant methionyl-tRNA synthetase-based toolkit to assess induced-mesenchymal stromal cell secretome in mixed-culture disease models

一种基于突变型甲硫氨酰-tRNA合成酶的工具包,用于评估混合培养疾病模型中诱导间充质基质细胞的分泌组

Jeremy D Burgess ,Danilyn Amerna ,Emily S Norton ,Tammee M Parsons ,Ralph B Perkerson 3rd ,Ayman H Faroqi ,Zbigniew K Wszolek ,Hugo Guerrero Cazares ,Takahisa Kanekiyo ,Marion Delenclos ,Pamela J McLean

LRP1 in vascular mural cells modulates cerebrovascular integrity and function in the presence of APOE4

在APOE4存在的情况下,血管壁细胞中的LRP1调节脑血管的完整性和功能。

Hiroshi Oue ,Yu Yamazaki ,Wenhui Qiao ,Chen Yuanxin ,Yingxue Ren ,Aishe Kurti ,Francis Shue ,Tammee M Parsons ,Ralph B Perkerson ,Keiji Kawatani ,Ni Wang ,Skylar C Starling ,Bhaskar Roy ,Ioana-Emilia Mosneag ,Tomonori Aikawa ,Marie-Louise Holm ,Chia-Chen Liu ,Yasuteru Inoue ,Patrick M Sullivan ,Yan W Asmann ,Betty Ys Kim ,Guojun Bu ,Takahisa Kanekiyo

A Mutant Methionyl-tRNA Synthetase-Based toolkit to assess induced-Mesenchymal Stromal Cell secretome in mixed-culture disease models

基于突变型甲硫氨酰-tRNA 合成酶的工具包,用于评估混合培养疾病模型中的诱导间充质基质细胞分泌组

Jeremy D Burgess, Danilyn Amerna, Emily S Norton, Tammee M Parsons, Ralph B Perkerson 3rd, Ayman H Faroqi, Zbigniew K Wszolek, Hugo Guerrero Cazares, Takahisa Kanekiyo, Marion Delenclos, Pamela J McLean

Loss of Tmem106b leads to cerebellum Purkinje cell death and motor deficits

Tmem106b的缺失会导致小脑浦肯野细胞死亡和运动功能障碍。

Rademakers, Rosa; Nicholson, Alexandra M; Ren, Yingxue; Koga, Shunsuke; Nguyen, Hung Phuoc; Brooks, Mieu; Qiao, Wenhui; Quicksall, Zachary S; Matchett, Billie; Perkerson, Ralph B; Kurti, Aishe; Castanedes-Casey, Monica; Phillips, Virginia; Librero, Ariston L; Fernandez De Castro, Cristhoper H; Baker, Matthew C; Roemer, Shanu F; Murray, Melissa E; Asmann, Yan; Fryer, John D; Bu, Guojun; Dickson, Dennis W; Zhou, Xiaolai