日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Alzheimer's disease and its progression reduce pyramidal cell gain and connectivity

阿尔茨海默病及其进展会降低锥体细胞的增益和连接性。

Lanskey, Juliette H; Jafarian, Amirhossein; Karadag, Melek; Kocagoncu, Ece; Williams, Rebecca S; Yadav, Pranay; Quinn, Andrew J; Pitt, Jemma; Thayanandan, Tony; Lowe, Stephen; Perkinton, Michael; Timmers, Maarten; Raymont, Vanessa; Singh, Krish D; Woolrich, Mark; Nobre, Anna C; Henson, Richard N; Rowe, James B

Phase 1, randomized trials of MEDI1341: cerebrospinal fluid free α-synuclein lowered by >50

MEDI1341 的 1 期随机试验:脑脊液游离 α-突触核蛋白降低 >50

Shering, Craig; Pomfret, Michael; Kubiak, Robert J; Pouliquen, Isabelle J; Yin, Wei; Simen, Arthur; Ratti, Elena; Hussain, Zubair; Perkinton, Michael; Tan, Keith; Scott, Kirsten M; Ostenfeld, Thor; Chessell, Iain

Expression of human A53T alpha-synuclein without endogenous rat alpha-synuclein fails to elicit Parkinson's disease-related phenotypes in a novel humanized rat model.

在新型人源化大鼠模型中,表达人类 A53T α-突触核蛋白而没有内源性大鼠 α-突触核蛋白,无法引起帕金森病相关表型

Polinski Nicole K, Puoliväli Jukka, Rauhala Leena, Stenius Taina-Kaisa, Bragge Timo, Parkkari Teija, Penttinen Anna-Maija, Chen Yi, Mabrouk Omar S, Glajch Kelly E, Hirst Warren D, Perkinton Michael, Martinez Terina N, Frasier Mark A

cGAS-STING signalling regulates microglial chemotaxis in genome instability

cGAS-STING 信号调节基因组不稳定状态下的小胶质细胞趋化性

Emily J Talbot, Lisha Joshi, Peter Thornton, Mahya Dezfouli, Kalliopi Tsafou, Michael Perkinton, Svetlana V Khoronenkova

Tau protein profiling in tauopathies: a human brain study

tau蛋白病中tau蛋白谱分析:一项人脑研究

Juan Lantero-Rodriguez # ,Elena Camporesi # ,Laia Montoliu-Gaya ,Johan Gobom ,Diana Piotrowska ,Maria Olsson ,Irena Matečko Burmann ,Bruno Becker ,Ann Brinkmalm ,Björn M Burmann ,Michael Perkinton ,Nicholas J Ashton ,Nick C Fox ,Tammaryn Lashley ,Henrik Zetterberg ,Kaj Blennow # ,Gunnar Brinkmalm #

P2X7R influences tau aggregate burden in human tauopathies and shows distinct signalling in microglia and astrocytes

P2X7R影响人类tau蛋白病中的tau蛋白聚集负荷,并在小胶质细胞和星形胶质细胞中表现出不同的信号传导。

Paula Beltran-Lobo ,Martina M Hughes ,Claire Troakes ,Cara L Croft ,Huzefa Rupawala ,Daniel Jutzi ,Marc-David Ruepp ,Maria Jimenez-Sanchez ,Michael S Perkinton ,Michael Kassiou ,Todd E Golde ,Diane P Hanger ,Alexei Verkhratsky ,Beatriz G Perez-Nievas ,Wendy Noble

Tau and Amyloid β Protein in Patient-Derived Aqueous Brain Extracts Act Concomitantly to Disrupt Long-Term Potentiation in Vivo

患者脑水提取物中的 Tau 和淀粉样 β 蛋白同时作用,破坏体内长期增强作用

Tomas Ondrejcak, Igor Klyubin, Neng-Wei Hu, Tiernan T O'Malley, Grant T Corbett, Róisín Winters, Michael S Perkinton, Andy Billinton, Jack A Prenderville, Dominic M Walsh, Michael J Rowan

PrP is a central player in toxicity mediated by soluble aggregates of neurodegeneration-causing proteins

PrP是可溶性神经退行性疾病致病蛋白聚集体介导的毒性作用的核心参与者。

Corbett, Grant T; Wang, Zemin; Hong, Wei; Colom-Cadena, Marti; Rose, Jamie; Liao, Meichen; Asfaw, Adhana; Hall, Tia C; Ding, Lai; DeSousa, Alexandra; Frosch, Matthew P; Collinge, John; Harris, David A; Perkinton, Michael S; Spires-Jones, Tara L; Young-Pearse, Tracy L; Billinton, Andrew; Walsh, Dominic M

Learnings about the complexity of extracellular tau aid development of a blood-based screen for Alzheimer's disease

对细胞外tau蛋白复杂性的了解有助于开发基于血液的阿尔茨海默病筛查方法

Chen, Zhicheng; Mengel, David; Keshavan, Ashvini; Rissman, Robert A; Billinton, Andrew; Perkinton, Michael; Percival-Alwyn, Jennifer; Schultz, Aaron; Properzi, Michael; Johnson, Keith; Selkoe, Dennis J; Sperling, Reisa A; Patel, Purvish; Zetterberg, Henrik; Galasko, Douglas; Schott, Jonathan M; Walsh, Dominic M

Extracellular Monomeric and Aggregated Tau Efficiently Enter Human Neurons through Overlapping but Distinct Pathways

细胞外单体和聚集的 Tau 通过重叠但不同的途径有效进入人类神经元

Lewis D Evans, Thomas Wassmer, Graham Fraser, James Smith, Michael Perkinton, Andrew Billinton, Frederick J Livesey