日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Allosteric modulation of the solute carrier transporter SLC39A8 potentiates manganese and cadmium uptake

溶质载体转运蛋白SLC39A8的变构调节可增强锰和镉的吸收。

Damm-Ganamet, Kelly L; Moon, Clara; Wickenden, Alan D; Tichenor, Mark; Ge, Yunhui; Mercado-Marin, Eduardo V; Chiou, Brian; Manughian-Peter, Ayla; Mirzadegan, Taraneh; Venable, Jennifer D; Xavier, Ramnik J; Towne, Jennifer E; Graham, Daniel B; Perrigoue, Jacqueline

Gene coexpression networks reveal a broad role for lncRNAs in inflammatory bowel disease

基因共表达网络揭示了lncRNA在炎症性肠病中的广泛作用

Johnson, John L; Sargsyan, Davit; Neiman, Eric M; Hart, Amy; Stojmirovic, Aleksandar; Kosoy, Roman; Irizar, Haritz; Suárez-Fariñas, Mayte; Song, Won-Min; Argmann, Carmen; Avey, Stefan; Shmuel-Galia, Liraz; Vierbuchen, Tim; Bongers, Gerold; Sun, Yu; Edelstein, Leonard; Perrigoue, Jacqueline; Towne, Jennifer E; Hall, Aisling O'Hara; Fitzgerald, Katherine A; Hoebe, Kasper

Biopsy and blood-based molecular biomarker of inflammation in IBD

IBD 的活检和血液分子生物标志物炎症

Argmann, Carmen; Hou, Ruixue; Ungaro, Ryan C; Irizar, Haritz; Al-Taie, Zainab; Huang, Ruiqi; Kosoy, Roman; Venkat, Swati; Song, Won-Min; Di'Narzo, Antonio F; Losic, Bojan; Hao, Ke; Peters, Lauren; Comella, Phillip H; Wei, Gabrielle; Atreja, Ashish; Mahajan, Milind; Iuga, Alina; Desai, Prerak T; Branigan, Patrick; Stojmirovic, Aleksandar; Perrigoue, Jacqueline; Brodmerkel, Carrie; Curran, Mark; Friedman, Joshua R; Hart, Amy; Lamousé-Smith, Esi; Wehkamp, Jan; Mehandru, Saurabh; Schadt, Eric E; Sands, Bruce E; Dubinsky, Marla C; Colombel, Jean-Frederic; Kasarskis, Andrew; Suárez-Fariñas, Mayte

Integrative Analysis of the Inflammatory Bowel Disease Serum Metabolome Improves Our Understanding of Genetic Etiology and Points to Novel Putative Therapeutic Targets

对炎症性肠病血清代谢组的整合分析增进了我们对遗传病因的理解,并指出了新的潜在治疗靶点。

Di'Narzo, Antonio F; Houten, Sander M; Kosoy, Roman; Huang, Ruiqi; Vaz, Frédéric M; Hou, Ruixue; Wei, Gabrielle; Wang, Wenhui; Comella, Phillip H; Dodatko, Tetyana; Rogatsky, Eduard; Stojmirovic, Aleksandar; Brodmerkel, Carrie; Perrigoue, Jacqueline; Hart, Amy; Curran, Mark; Friedman, Joshua R; Zhu, Jun; Agrawal, Manasi; Cho, Judy; Ungaro, Ryan; Dubinsky, Marla C; Sands, Bruce E; Suárez-Fariñas, Mayte; Schadt, Eric E; Colombel, Jean-Frédéric; Kasarskis, Andrew; Hao, Ke; Argmann, Carmen

Loss of Ribosomal Protein Paralog Rpl22-like1 Blocks Lymphoid Development without Affecting Protein Synthesis

核糖体蛋白旁系同源物Rpl22-like1的缺失会阻碍淋巴细胞发育,但不影响蛋白质合成。

Fahl, Shawn P; Sertori, Robert; Zhang, Yong; Contreras, Alejandra V; Harris, Bryan; Wang, Minshi; Perrigoue, Jacqueline; Balachandran, Siddharth; Kennedy, Brian K; Wiest, David L

Altered Intestinal ACE2 Levels Are Associated With Inflammation, Severe Disease, and Response to Anti-Cytokine Therapy in Inflammatory Bowel Disease

肠道ACE2水平改变与炎症性肠病中的炎症、严重疾病以及对抗细胞因子治疗的反应相关

Potdar, Alka A; Dube, Shishir; Naito, Takeo; Li, Katherine; Botwin, Gregory; Haritunians, Talin; Li, Dalin; Casero, David; Yang, Shaohong; Bilsborough, Janine; Perrigoue, Jacqueline G; Denson, Lee A; Daly, Mark; Targan, Stephan R; Fleshner, Phillip; Braun, Jonathan; Kugathasan, Subra; Stappenbeck, Thaddeus S; McGovern, Dermot P B

Deep Analysis of the Peripheral Immune System in IBD Reveals New Insight in Disease Subtyping and Response to Monotherapy or Combination Therapy

对IBD患者外周免疫系统的深入分析揭示了疾病亚型划分以及对单药治疗或联合治疗反应的新见解

Kosoy, Roman; Kim-Schulze, Seunghee; Rahman, Adeeb; Friedman, Joshua R; Huang, Ruiqi; Peters, Lauren A; Amir, El-Ad; Perrigoue, Jacqueline; Stojmirovic, Aleksandar; Song, Won-Min; Ke, Hao; Ungaro, Ryan; Mehandru, Saurabh; Cho, Judy; Dubinsky, Marla; Curran, Mark; Brodmerkel, Carrie; Schadt, Eric E; Sands, Bruce E; Colombel, Jean-Frederic; Kasarskis, Andrew; Argmann, Carmen A; Suárez-Fariñas, Mayte

Epithelial Cell Biomarkers Are Predictive of Response to Biologic Agents in Crohn's Disease

上皮细胞生物标志物可预测克罗恩病对生物制剂的反应

Osterman, Mark T; VanDussen, Kelli L; Gordon, Ilyssa O; Davis, Elisabeth M; Li, Katherine; Simpson, Kate; Ciorba, Matthew; Glover, Sarah C; Abraham, Bincy; Guo, Xueyan; Yee, Eric U; Allard, Felicia D; Perrigoue, Jacqueline G; Claggett, Brian; Shen, Bo; Stappenbeck, Thaddeus S; Liu, Julia J

Abnormal Small Intestinal Epithelial Microvilli in Patients With Crohn's Disease

克罗恩病患者小肠上皮微绒毛异常

VanDussen, Kelli L; Stojmirović, Aleksandar; Li, Katherine; Liu, Ta-Chiang; Kimes, Patrick K; Muegge, Brian D; Simpson, Katherine F; Ciorba, Matthew A; Perrigoue, Jacqueline G; Friedman, Joshua R; Towne, Jennifer E; Head, Richard D; Stappenbeck, Thaddeus S

Blood and Intestine eQTLs from an Anti-TNF-Resistant Crohn's Disease Cohort Inform IBD Genetic Association Loci.

来自抗 TNF 耐药克罗恩病队列的血液和肠道 eQTL 为 IBD 遗传关联位点提供了信息

Di Narzo Antonio F, Peters Lauren A, Argmann Carmen, Stojmirovic Aleksandar, Perrigoue Jacqueline, Li Katherine, Telesco Shannon, Kidd Brian, Walker Jennifer, Dudley Joel, Cho Judy, Schadt Eric E, Kasarskis Andrew, Curran Mark, Dobrin Radu, Hao Ke