日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Small molecule glucokinase activators disturb lipid homeostasis and induce fatty liver in rodents: a warning for therapeutic applications in humans

小分子葡萄糖激酶激活剂会扰乱啮齿动物的脂质稳态并诱发脂肪肝:这对人类的治疗应用敲响了警钟。

De Ceuninck, Frédéric; Kargar, Catherine; Ilic, Catherine; Caliez, Audrey; Rolin, Jean-Olivier; Umbdenstock, Thierry; Vinson, Cédric; Combettes, Murielle; de Fanti, Brant; Harley, Elizabeth; Sadlo, Marjorie; Lefèvre, Anne-Laure; Broux, Olivier; Wierzbicki, Michel; Fourquez, Jean-Marie; Perron-Sierra, Françoise; Kotschy, András; Ktorza, Alain

S 50131 and S 51434, two novel small molecule glucokinase activators, lack chronic efficacy despite potent acute antihyperglycaemic activity in diabetic mice

两种新型小分子葡萄糖激酶激活剂S 50131和S 51434,尽管在糖尿病小鼠中表现出显著的急性降血糖活性,但缺乏长期疗效。

De Ceuninck, Frédéric; Kargar, Catherine; Charton, Yves; Goldstein, Solo; Perron-Sierra, Françoise; Ilic, Catherine; Caliez, Audrey; Rolin, Jean-Olivier; Sadlo, Marjorie; Harley, Elizabeth; Vinson, Cédric; Ktorza, Alain

β5 integrin is the major contributor to the αVintegrin-mediated blockade of HIV-1 replication

β5整合素是αV整合素介导的HIV-1复制阻断的主要贡献者

Ester Ballana, Eduardo Pauls, Bonaventura Clotet, Françoise Perron-Sierra, Gordon C Tucker, José A Esté