日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Spiropyrimidinetriones: a Class of DNA Gyrase Inhibitors with Activity against Mycobacterium tuberculosis and without Cross-Resistance to Fluoroquinolones

螺嘧啶三酮类:一类对结核分枝杆菌具有活性且与氟喹诺酮类药物无交叉耐药性的DNA促旋酶抑制剂

Basarab, Gregory S; Ghorpade, Sandeep; Gibhard, Liezl; Mueller, Rudolf; Njoroge, Mathew; Peton, Nashied; Govender, Preshendren; Massoudi, Lisa M; Robertson, Gregory Thomas; Lenaerts, Anne J; Boshoff, Helena Ingrid; Joerss, Douglas; Parish, Tanya; Durand-Reville, Thomas F; Perros, Manos; Singh, Vinayak; Chibale, Kelly

Untargeted Metabolomics To Ascertain Antibiotic Modes of Action

利用非靶向代谢组学确定抗生素的作用机制

Vincent, Isabel M; Ehmann, David E; Mills, Scott D; Perros, Manos; Barrett, Michael P

Responding to the challenge of untreatable gonorrhea: ETX0914, a first-in-class agent with a distinct mechanism-of-action against bacterial Type II topoisomerases

应对无法治愈的淋病难题:ETX0914,一种具有独特作用机制、可对抗细菌 II 型拓扑异构酶的首创药物

Basarab, Gregory S; Kern, Gunther H; McNulty, John; Mueller, John P; Lawrence, Kenneth; Vishwanathan, Karthick; Alm, Richard A; Barvian, Kevin; Doig, Peter; Galullo, Vincent; Gardner, Humphrey; Gowravaram, Madhusudhan; Huband, Michael; Kimzey, Amy; Morningstar, Marshall; Kutschke, Amy; Lahiri, Sushmita D; Perros, Manos; Singh, Renu; Schuck, Virna J A; Tommasi, Ruben; Walkup, Grant; Newman, Joseph V

Lersivirine, a nonnucleoside reverse transcriptase inhibitor with activity against drug-resistant human immunodeficiency virus type 1.

勒西韦林是一种非核苷类逆转录酶抑制剂,对耐药性人类免疫缺陷病毒1型具有活性

Corbau Romuald, Mori Julie, Phillips Chris, Fishburn Lesley, Martin Alex, Mowbray Charles, Panton Wendy, Smith-Burchnell Caroline, Thornberry Adele, Ringrose Heather, Knöchel Thorsten, Irving Steve, Westby Mike, Wood Anthony, Perros Manos

New small-molecule inhibitor class targeting human immunodeficiency virus type 1 virion maturation.

一种靶向人类免疫缺陷病毒1型病毒颗粒成熟的新型小分子抑制剂

Blair Wade S, Cao Joan, Fok-Seang Juin, Griffin Paul, Isaacson Jason, Jackson R Lynn, Murray Edward, Patick Amy K, Peng Qinghai, Perros Manos, Pickford Chris, Wu Hua, Butler Scott L

Maraviroc (UK-427,857), a potent, orally bioavailable, and selective small-molecule inhibitor of chemokine receptor CCR5 with broad-spectrum anti-human immunodeficiency virus type 1 activity.

马拉维罗(UK-427,857)是一种强效、口服生物利用度高、选择性的趋化因子受体 CCR5 小分子抑制剂,具有广谱抗人类免疫缺陷病毒 1 型活性

Dorr Patrick, Westby Mike, Dobbs Susan, Griffin Paul, Irvine Becky, Macartney Malcolm, Mori Julie, Rickett Graham, Smith-Burchnell Caroline, Napier Carolyn, Webster Rob, Armour Duncan, Price David, Stammen Blanda, Wood Anthony, Perros Manos