日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Design of a Targeted Covalent Probe to Interrogate the DNA Polymerase Activity of Polθ

设计靶向共价探针以检测Polθ的DNA聚合酶活性

Bubenik, Monica; Mader, Pavel; Orlicky, Stephen; Perryman, Alexander L; Hamel, Martine; Godbout, Claude; Falgueyret, Jean-Pierre; Kurinov, Igor; Wong, Cassandra; Gingras, Anne Claude; Mamane, Yael; Zinda, Michael; Morris, Stephen J; Gallant, Michel; Sfeir, Agnel; Black, W Cameron; Durocher, Daniel; Zimmermann, Michal; Sicheri, Frank

Intrabacterial Metabolism Obscures the Successful Prediction of an InhA Inhibitor of Mycobacterium tuberculosis

细菌内代谢阻碍了结核分枝杆菌 InhA 抑制剂的成功预测

Wang, Xin; Perryman, Alexander L; Li, Shao-Gang; Paget, Steve D; Stratton, Thomas P; Lemenze, Alex; Olson, Arthur J; Ekins, Sean; Kumar, Pradeep; Freundlich, Joel S

The A-Z of Zika drug discovery

寨卡病毒药物研发的AZ

Mottin, Melina; Borba, Joyce V V B; Braga, Rodolpho C; Torres, Pedro H M; Martini, Matheus C; Proenca-Modena, Jose Luiz; Judice, Carla C; Costa, Fabio T M; Ekins, Sean; Perryman, Alexander L; Horta Andrade, Carolina

Novel Pyrimidines as Antitubercular Agents

新型嘧啶类抗结核药物

Inoyama, Daigo; Paget, Steven D; Russo, Riccardo; Kandasamy, Srinivasan; Kumar, Pradeep; Singleton, Eric; Occi, James; Tuckman, Margareta; Zimmerman, Matthew D; Ho, Hsin Pin; Perryman, Alexander L; Dartois, Véronique; Connell, Nancy; Freundlich, Joel S

Comparing and Validating Machine Learning Models for Mycobacterium tuberculosis Drug Discovery.

比较和验证用于结核分枝杆菌药物发现的机器学习模型

Lane Thomas, Russo Daniel P, Zorn Kimberley M, Clark Alex M, Korotcov Alexandru, Tkachenko Valery, Reynolds Robert C, Perryman Alexander L, Freundlich Joel S, Ekins Sean

A Novel Small-Molecule Inhibitor of the Mycobacterium tuberculosis Demethylmenaquinone Methyltransferase MenG Is Bactericidal to Both Growing and Nutritionally Deprived Persister Cells

一种新型结核分枝杆菌去甲基甲萘醌甲基转移酶 MenG 小分子抑制剂对生长中的细菌和营养缺乏的持续性细菌均具有杀菌作用。

Sukheja, Paridhi; Kumar, Pradeep; Mittal, Nisha; Li, Shao-Gang; Singleton, Eric; Russo, Riccardo; Perryman, Alexander L; Shrestha, Riju; Awasthi, Divya; Husain, Seema; Soteropoulos, Patricia; Brukh, Roman; Connell, Nancy; Freundlich, Joel S; Alland, David

Predicting Mouse Liver Microsomal Stability with "Pruned" Machine Learning Models and Public Data

利用“剪枝”机器学习模型和公共数据预测小鼠肝微粒体稳定性

Perryman, Alexander L; Stratton, Thomas P; Ekins, Sean; Freundlich, Joel S

OpenZika: An IBM World Community Grid Project to Accelerate Zika Virus Drug Discovery

OpenZika:IBM全球社区网格项目,旨在加速寨卡病毒药物研发

Ekins, Sean; Perryman, Alexander L; Horta Andrade, Carolina

Biological evaluation of potent triclosan-derived inhibitors of the enoyl-acyl carrier protein reductase InhA in drug-sensitive and drug-resistant strains of Mycobacterium tuberculosis

对结核分枝杆菌药物敏感株和耐药株中烯酰-酰基载体蛋白还原酶InhA的强效三氯生衍生物抑制剂进行生物学评价

Stec, Jozef; Vilchèze, Catherine; Lun, Shichun; Perryman, Alexander L; Wang, Xin; Freundlich, Joel S; Bishai, William; Jacobs, William R Jr; Kozikowski, Alan P

Small molecule regulation of protein conformation by binding in the Flap of HIV protease

小分子通过与 HIV 蛋白酶的瓣状结构结合来调控蛋白质构象

Tiefenbrunn, Theresa; Forli, Stefano; Baksh, Michael M; Chang, Max W; Happer, Meaghan; Lin, Ying-Chuan; Perryman, Alexander L; Rhee, Jin-Kyu; Torbett, Bruce E; Olson, Arthur J; Elder, John H; Finn, M G; Stout, C David