日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Genomic analyses of pneumococci from children with sickle cell disease expose host-specific bacterial adaptations and deficits in current interventions

对镰状细胞病患儿肺炎球菌的基因组分析揭示了宿主特异性的细菌适应性以及当前干预措施的不足之处。

Carter, Robert; Wolf, Joshua; van Opijnen, Tim; Muller, Martha; Obert, Caroline; Burnham, Corinna; Mann, Beth; Li, Yimei; Hayden, Randall T; Pestina, Tamara; Persons, Derek; Camilli, Andrew; Flynn, Patricia M; Tuomanen, Elaine I; Rosch, Jason W

Hydroxyurea therapy of a murine model of sickle cell anemia inhibits the progression of pneumococcal disease by down-modulating E-selectin

在镰状细胞贫血小鼠模型中,羟基脲疗法可通过下调E-选择素来抑制肺炎球菌疾病的进展。

Lebensburger, Jeffrey D; Howard, Thad; Hu, Yunming; Pestina, Tamara I; Gao, Geli; Johnson, Melissa; Zakharenko, Stanislav S; Ware, Russell E; Tuomanen, Elaine I; Persons, Derek A; Rosch, Jason W

High-efficiency transduction of rhesus hematopoietic repopulating cells by a modified HIV1-based lentiviral vector

利用改良的基于HIV1的慢病毒载体高效转导恒河猴造血干细胞

Uchida, Naoya; Hargrove, Phillip W; Lap, Coen J; Evans, Molly E; Phang, Oswald; Bonifacino, Aylin C; Krouse, Allen E; Metzger, Mark E; Nguyen, Anh-Dao; Hsieh, Matthew M; Wolfsberg, Tyra G; Donahue, Robert E; Persons, Derek A; Tisdale, John F

Cell Membrane-associated heparan sulfate is a receptor for prototype foamy virus in human, monkey, and rodent cells

细胞膜相关的硫酸乙酰肝素是人类、猴子和啮齿动物细胞中原型泡沫病毒的受体。

Nasimuzzaman, Md; Persons, Derek A

Development of gene therapy for thalassemia

地中海贫血基因疗法的研发

Nienhuis, Arthur W; Persons, Derek A

Hydroxyurea therapy requires HbF induction for clinical benefit in a sickle cell mouse model

在镰状细胞小鼠模型中,羟基脲疗法需要诱导HbF才能发挥临床疗效。

Lebensburger, Jeffrey D; Pestina, Tamara I; Ware, Russell E; Boyd, Kelli L; Persons, Derek A

Sustained high-level polyclonal hematopoietic marking and transgene expression 4 years after autologous transplantation of rhesus macaques with SIV lentiviral vector-transduced CD34+ cells

在恒河猴自体移植SIV慢病毒载体转导的CD34+细胞4年后,持续存在高水平的多克隆造血标记和转基因表达。

Kim, Yoo-Jin; Kim, Yoon-Sang; Larochelle, Andre; Renaud, Gabriel; Wolfsberg, Tyra G; Adler, Rima; Donahue, Robert E; Hematti, Peiman; Hong, Bum-Kee; Roayaei, Jean; Akagi, Keiko; Riberdy, Janice M; Nienhuis, Arthur W; Dunbar, Cynthia E; Persons, Derek A

Amelioration of murine beta-thalassemia through drug selection of hematopoietic stem cells transduced with a lentiviral vector encoding both gamma-globin and the MGMT drug-resistance gene

通过药物筛选转导了编码γ-珠蛋白和MGMT耐药基因的慢病毒载体的造血干细胞,可改善小鼠β-地中海贫血。

Zhao, Huifen; Pestina, Tamara I; Nasimuzzaman, Md; Mehta, Perdeep; Hargrove, Phillip W; Persons, Derek A

In vivo selection of hematopoietic progenitor cells and temozolomide dose intensification in rhesus macaques through lentiviral transduction with a drug resistance gene.

通过慢病毒转导药物耐药基因,在恒河猴体内选择造血祖细胞并增强替莫唑胺剂量

Larochelle Andre, Choi Uimook, Shou Yan, Naumann Nora, Loktionova Natalia A, Clevenger Joshua R, Krouse Allen, Metzger Mark, Donahue Robert E, Kang Elizabeth, Stewart Clinton, Persons Derek, Malech Harry L, Dunbar Cynthia E, Sorrentino Brian P

Optimized lentiviral vector design improves titer and transgene expression of vectors containing the chicken beta-globin locus HS4 insulator element

优化的慢病毒载体设计提高了含有鸡β-珠蛋白基因座HS4绝缘子元件的载体的滴度和转基因表达。

Hanawa, Hideki; Yamamoto, Motoko; Zhao, Huifen; Shimada, Takashi; Persons, Derek A