日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Inhibition of GluN2B-containing N-methyl-D-aspartate receptors by radiprodil.

雷迪普罗地尔对含 GluN2B 的 N-甲基-D-天冬氨酸受体的抑制作用。

Banke Tue G, Regan Michael C, Perszyk Riley E, Zhang Lu, Xing Hao, Chen Jiahui, Won Sehoon, Simorowski Noriko, Diaz Eva S, Kim Sukhan, Song Rui, Rong Jian, Zhou Xin, Chaudhary Ahmad F, Zhang Jing, Traynelis John F, McDaniels Ellington D, Nitsche Karolina, Roache Steve, Raymond Christopher S, Low Chian-Ming, Myers Scott J, Roche Katherine W, Liang Steven H, Traynelis Stephen F, Furukawa Hiro, Yuan Hongjie

Memantine treatment in individuals with GRIN gain-of-function variants is associated with improvements in behavior, development, and seizure frequency

在携带GRIN功能获得性变异的个体中,美金刚治疗与行为、发育和癫痫发作频率的改善相关。

Karnstedt, Maike; Perszyk, Riley E; Myers, Scott J; McDaniels, Ellington; Somorai, Marta; Borggraefe, Ingo; Veenma, Danielle C M; Schoonjans, An-Sofie; Striano, Pasquale; Fantaneanu, Tadeu A; Syrbe, Steffen; Park, Kristen; Chen, Wenjuan; Yuan, Hongjie; Traynelis, Stephen F; Benke, Timothy A; Lemke, Johannes R; Krey, Ilona

Gene Portals: A Framework for Integrating Clinical, Functional, and Structural Evidence into Rare Disease Variant Classification

基因门户:将临床、功能和结构证据整合到罕见病变异分类中的框架

Brünger, Tobias; Krey, Ilona; Kim, Suyeon; Klöckner, Chiara; Myers, Scott J; Johannesen, Katrine M; Stefanski, Arthur; Taylor, Gary; Perez-Palma, Eduardo; Macnee, Marie; Schorge, Stephanie; Dahl, Rebekka S; Yuan, Hongjie; Perszyk, Riley E; Kim, Sukhan; Bajaj, Sunanjay; Helbig, Ingo; Pan, Jen Q; Farrant, Mark; Wollmuth, Lonnie; Wyllie, David J A; Kurganov, Erkin; Baez, David; Zuberi, Sameer; Boßelmann, Christian M; Lerche, Holger; Mantegazza, Massimo; Cestèle, Sandrine; May, Patrick; Ivaniuk, Alina; Meskis, Mary Anne; Hood, Veronica; Schust, Leah; Goodspeed, Kimberly; Kang, Jing-Qiong; Freed, Amber; Gati, Cornelius; Montanucci, Ludovica; Wuster, Arthur; Trinidad, Marena; Froelich, Steven; Deng, Alexander T; Serrano, Ángel Aledo; Borovikov, Artem; Sharkov, Artem; Bouman, Arjan; Hajianpour, M J; Pal, Deb K; Danvoye, Leslie; Lederer, Damien; Balci, Tugce R; Hagebeuk, Eveline E O; Heidlebaugh, Alexis; Oetjens, Kathryn; Hoffman, Trevor L; Striano, Pasquale; Williams, Sarah Drewes; van Engelen, Kalene; Howell, Katherine B; Khoury, Jean; Benke, Tim A; Strehlow, Vincent; Platzer, Konrad; Ramsey, Amy; Manaster, Lisa; Malepati, Sunitha; Fox, Pangkong; Noebels, Jeffrey; Chung, Wendy; Poduri, Annapurna; Stripe, Laina Lusk; Ruggiero, Sarah M; Cohen, Stacey; Smith, Lacey; Boesch, Sylvia; Wilmarth, Olivia; Prentice, Anna Jenne; Cha, Esther; Budnik, Nikita; Hommersom, Marina P; Kramer, Audra; Vanoye, Carlos G; Zhang, Guo-Qiang; Nothnagel, Michael; Palotie, Aarno; Daly, Mark J; George, Alfred L Jr; Zarate, Yuri A; Brunklaus, Andreas; Traynelis, Stephen F; Møller, Rikke S; Lemke, Johannes R; Lal, Dennis

Structural basis for channel gating and blockade in tri-heteromeric GluN1-2B-2D NMDA receptor.

三异聚体 GluN1-2B-2D NMDA 受体通道门控和阻断的结构基础

Kang Hyunook, Epstein Max, Banke Tue G, Perszyk Riley, Simorowski Noriko, Paladugu Srinu, Liotta Dennis C, Traynelis Stephen F, Furukawa Hiro

Selective enhancement of the interneuron network and gamma-band power via GluN2C/GluN2D NMDA receptor potentiation

通过GluN2C/GluN2D NMDA受体增强选择性增强中间神经元网络和γ波段功率

Camp, Chad R; Banke, Tue G; Xing, Hao; Yu, Kuai; Perszyk, Riley E; Epplin, Matthew P; Akins, Nicholas S; Zhang, Jing; Benke, Tim A; Yuan, Hongjie; Liotta, Dennis C; Traynelis, Stephen F

De novo GRIN variants in M3 helix associated with neurological disorders control channel gating of NMDA receptor

与神经系统疾病相关的 M3 螺旋中的新生 GRIN 变体控制 NMDA 受体的通道门控

Yuchen Xu, Rui Song, Riley E Perszyk, Wenjuan Chen, Sukhan Kim, Kristen L Park, James P Allen, Kelsey A Nocilla, Jing Zhang, Wenshu XiangWei, Anel Tankovic, Ellington D McDaniels, Rehan Sheikh, Ruth K Mizu, Manish M Karamchandani, Chun Hu, Hirofumi Kusumoto, Joseph Pecha, Gerarda Cappuccio, John Gai

Differential responses of disease-related GRIN variants located in pore-forming M2 domain of N-methyl-D-aspartate receptor to FDA-approved inhibitors.

位于 N-甲基-D-天冬氨酸受体孔形成 M2 结构域中的疾病相关 GRIN 变体对 FDA 批准的抑制剂的不同反应

Song Rui, Zhang Jin, Perszyk Riley E, Camp Chad R, Tang Weiting, Kannan Varun, Li Jia, Xu Yuchen, Chen Jiahui, Li Yinlong, Liang Steven H, Traynelis Stephen F, Yuan Hongjie

Clinical features, functional consequences, and rescue pharmacology of missense GRID1 and GRID2 human variants

GRID1 和 GRID2 错义人类变异的临床特征、功能后果和救援药理学

James P Allen, Kathryn B Garber, Riley Perszyk, Cara T Khayat, Steven A Kell, Maki Kaneko, Catherine Quindipan, Sulagna Saitta, Roger L Ladda, Stacy Hewson, Michal Inbar-Feigenberg, Chitra Prasad, Asuri N Prasad, Leah Olewiler, Weiyi Mu, Liana S Rosenthal, Marcello Scala, Pasquale Striano, Federico

Mechanisms of Action Underlying Conductance-Modifying Positive Allosteric Modulators of the NMDA Receptor.

NMDA受体电导调节正变构调节剂的作用机制

Ullman Elijah Z, Perszyk Riley E, Paladugu Srinu, Fritzemeier Russell G, Akins Nicholas S, Jacobs Leon, Liotta Dennis C, Traynelis Stephen F

Selective Enhancement of the Interneuron Network and Gamma-Band Power via GluN2C/GluN2D NMDA Receptor Potentiation

通过 GluN2C/GluN2D NMDA 受体增强选择性增强中间神经元网络和伽马波段功率

Camp, Chad R; Banke, Tue G; Xing, Hao; Yu, Kuai; Perszyk, Riley E; Epplin, Matthew P; Akins, Nicholas S; Zhang, Jing; Benke, Tim A; Yuan, Hongjie; Liotta, Dennis C; Traynelis, Stephen F