日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Macrocyclic Carbon-Linked Pyrazoles As Novel Inhibitors of MCL-1

大环碳连接吡唑类化合物作为MCL-1的新型抑制剂

Demin, Samuël; Peschiulli, Aldo; Velter, Adriana I; Vos, Ann; De Boeck, Benoît; Miller, Bradley; Rombouts, Frederik J R; Reuillon, Tristan; Lento, William; Blanco, Maria Dominguez; Jouffroy, Matthieu; Steyvers, Helena; Bekkers, Mariette; Altrocchi, Cristina; Pietrak, Beth; Koo, Seong Joo; Szewczuk, Lawrence; Attar, Ricardo; Philippar, Ulrike

A Brain-Penetrant and Bioavailable Pyrazolopiperazine BACE1 Inhibitor Elicits Sustained Reduction of Amyloid β In Vivo

一种能穿透血脑屏障且具有生物利用度的吡唑哌嗪类BACE1抑制剂可在体内持续降低β-淀粉样蛋白水平

Peschiulli, Aldo; Oehlrich, Daniel; Van Gool, Michiel; Austin, Nigel; Van Brandt, Sven; Surkyn, Michel; De Cleyn, Michel; Vos, Ann; Tresadern, Gary; Rombouts, Frederik J R; Macdonald, Gregor J; Moechars, Diederik; Trabanco, Andrés A; Gijsen, Harrie J M

Hydrogen Bonding Phase-Transfer Catalysis with Ionic Reactants: Enantioselective Synthesis of γ-Fluoroamines

利用离子反应物进行氢键相转移催化:γ-氟胺的对映选择性合成

Roagna, Giulia; Ascough, David M H; Ibba, Francesco; Vicini, Anna Chiara; Fontana, Alberto; Christensen, Kirsten E; Peschiulli, Aldo; Oehlrich, Daniel; Misale, Antonio; Trabanco, Andrés A; Paton, Robert S; Pupo, Gabriele; Gouverneur, Véronique