日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Multigenerational cell tracking of DNA replication and heritable DNA damage

利用多代细胞追踪DNA复制和遗传性DNA损伤

Andreas Panagopoulos # ,Merula Stout # ,Sinan Kilic ,Peter Leary ,Julia Vornberger ,Virginia Pasti ,Antonio Galarreta ,Aleksandra Lezaja ,Kyra Kirschenbühler ,Ralph Imhof ,Hubert Rehrauer ,Urs Ziegler ,Matthias Altmeyer

Inactivation of the tumor suppressor gene Apc synergizes with H. pylori to induce DNA damage in murine gastric stem and progenitor cells

肿瘤抑制基因Apc的失活与幽门螺杆菌协同作用,诱导小鼠胃干细胞和祖细胞的DNA损伤。

Jiazhuo He ,Zuzana Nascakova ,Peter Leary ,Giovanni Papa ,Tomas Valenta ,Konrad Basler ,Anne Müller

Treg-selective IL-2 starvation synergizes with CD40 activation to sustain durable responses in lymphoma models

Treg 选择性 IL-2 饥饿与 CD40 激活协同作用,在淋巴瘤模型中维持持久反应

Kristin Stirm, Peter Leary, Daria Wüst, Dominique Stark, Nicole Joller, Ufuk Karakus, Onur Boyman, Alexandar Tzankov, Anne Müller

Up-regulation of the PI3K/AKT and RHO/RAC/PAK signalling pathways in CHK1 inhibitor resistant Eµ-Myc lymphoma cells

CHK1 抑制剂耐药 Eµ-Myc 淋巴瘤细胞中 PI3K/AKT 和 RHO/RAC/PAK 信号通路上调

Jill E Hunter, Amy E Campbell, Scott Kerridge, Callum Fraser, Nicola L Hannaway, Saimir Luli, Iglika Ivanova, Philip J Brownridge, Jonathan Coxhead, Leigh Taylor, Peter Leary, Megan S R Hasoon, Claire E Eyers, Neil D Perkins

Regulation of CHK1 inhibitor resistance by a c-Rel and USP1 dependent pathway

c-Rel 和 USP1 依赖性途径调节 CHK1 抑制剂耐药性

Jill E Hunter, Amy E Campbell, Nicola L Hannaway, Scott Kerridge, Saimir Luli, Jacqueline A Butterworth, Helene Sellier, Reshmi Mukherjee, Nikita Dhillon, Praveen D Sudhindar, Ruchi Shukla, Philip J Brownridge, Hayden L Bell, Jonathan Coxhead, Leigh Taylor, Peter Leary, Megan S R Hasoon, Ian Collins

Mutation of the RelA(p65) Thr505 phosphosite disrupts the DNA replication stress response leading to CHK1 inhibitor resistance

RelA(p65) Thr505磷酸化位点的突变会破坏DNA复制应激反应,从而导致CHK1抑制剂耐药性。

Jill E Hunter # ,Amy E Campbell # ,Jacqueline A Butterworth ,Helene Sellier ,Nicola L Hannaway ,Saimir Luli ,Achilleas Floudas ,Niall S Kenneth ,Adam J Moore ,Philip J Brownridge ,Huw D Thomas ,Jonathan Coxhead ,Leigh Taylor ,Peter Leary ,Megan S R Hasoon ,Andrew M Knight ,Michelle D Garrett ,Ian Collins ,Claire E Eyers ,Neil D Perkins

Tumor cell-derived IL-10 promotes cell-autonomous growth and immune escape in diffuse large B-cell lymphoma

肿瘤细胞衍生的 IL-10 促进弥漫大 B 细胞淋巴瘤的细胞自主生长和免疫逃逸

Kristin Stirm, Peter Leary, Katrin Bertram, Nicolás Gonzalo Núñez, Daria Wüst, Christophe Boudesco, Els Verhoeyen, Thorsten Zenz, Burkhard Becher, Thomas Menter, Alexandar Tzankov, Anne Müller