日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Ion currents through Kir potassium channels are gated by anionic lipids

通过 Kir 钾通道的离子电流受阴离子脂质的控制

Ruitao Jin #, Sitong He #, Katrina A Black #, Oliver B Clarke, Di Wu, Jani R Bolla, Paul Johnson, Agalya Periasamy, Ahmad Wardak, Peter Czabotar, Peter M Colman, Carol V Robinson, Derek Laver, Brian J Smith, Jacqueline M Gulbis

Structure of the BAK-activating antibody 7D10 bound to BAK reveals an unexpected role for the α1-α2 loop in BAK activation

BAK激活抗体7D10与BAK结合的结构揭示了α1-α2环在BAK激活中意想不到的作用。

Adeline Y Robin #,Michelle S Miller #,Sweta Iyer,Melissa X Shi,Ahmad Z Wardak,Daisy Lio,Nicholas A Smith,Brian J Smith,Richard W Birkinshaw,Peter E Czabotar,Ruth M Kluck,Peter M Colman

An increase in mitochondrial TOM activates apoptosis to drive retinal neurodegeneration

线粒体 TOM 增加可激活细胞凋亡,从而驱动视网膜神经变性

Agalya Periasamy, Naomi Mitchell, Olga Zaytseva, Arjun S Chahal, Jiamin Zhao, Peter M Colman, Leonie M Quinn, Jacqueline M Gulbis

EBV BCL-2 homologue BHRF1 drives chemoresistance and lymphomagenesis by inhibiting multiple cellular pro-apoptotic proteins

EBV BCL-2 同源物 BHRF1 通过抑制多种细胞促凋亡蛋白来驱动化学耐药性和淋巴瘤形成

Leah Fitzsimmons, Rachel Cartlidge, Catherine Chang, Nenad Sejic, Laura C A Galbraith, Chathura D Suraweera, Deborah Croom-Carter, Grant Dewson, Rosemary J Tierney, Andrew I Bell, Clare Shannon-Lowe, Marco J Herold, Alan B Rickinson, Peter M Colman, David C S Huang, Andreas Strasser, Marc Kvansakul 

Structures of BCL-2 in complex with venetoclax reveal the molecular basis of resistance mutations

BCL-2 与维奈克拉复合的结构揭示了耐药突变的分子基础

Richard W Birkinshaw, Jia-Nan Gong, Cindy S Luo, Daisy Lio, Christine A White, Mary Ann Anderson, Piers Blombery, Guillaume Lessene, Ian J Majewski, Rachel Thijssen, Andrew W Roberts, David C S Huang, Peter M Colman, Peter E Czabotar

Conversion of Bim-BH3 from Activator to Inhibitor of Bak through Structure-Based Design

通过基于结构的设计将 Bim-BH3 从 Bak 激活剂转化为抑制剂

Jason M Brouwer, Ping Lan, Angus D Cowan, Jonathan P Bernardini, Richard W Birkinshaw, Mark F van Delft, Brad E Sleebs, Adeline Y Robin, Ahmad Wardak, Iris K Tan, Boris Reljic, Erinna F Lee, W Douglas Fairlie, Melissa J Call, Brian J Smith, Grant Dewson, Guillaume Lessene, Peter M Colman, Peter E Cz

Physiological restraint of Bak by Bcl-xL is essential for cell survival

Bcl-xL对Bak的生理抑制对细胞存活至关重要

Erinna F Lee, Stephanie Grabow, Stephane Chappaz, Grant Dewson, Colin Hockings, Ruth M Kluck, Marlyse A Debrincat, Daniel H Gray, Matthew T Witkowski, Marco Evangelista, Anne Pettikiriarachchi, Philippe Bouillet, Rachael M Lane, Peter E Czabotar, Peter M Colman, Brian J Smith, Benjamin T Kile, W Dou

The functional differences between pro-survival and pro-apoptotic B cell lymphoma 2 (Bcl-2) proteins depend on structural differences in their Bcl-2 homology 3 (BH3) domains

促存活和促凋亡 B 细胞淋巴瘤 2 (Bcl-2) 蛋白之间的功能差异取决于其 Bcl-2 同源性 3 (BH3) 结构域的结构差异

Erinna F Lee, Grant Dewson, Marco Evangelista, Anne Pettikiriarachchi, Grace J Gold, Haoran Zhu, Peter M Colman, W Douglas Fairlie

Structural insight into BH3 domain binding of vaccinia virus antiapoptotic F1L

对痘苗病毒抗凋亡 F1L 的 BH3 结构域结合的结构洞察

Stephanie Campbell, John Thibault, Ninad Mehta, Peter M Colman, Michele Barry, Marc Kvansakul

Evaluation of diverse α/β-backbone patterns for functional α-helix mimicry: analogues of the Bim BH3 domain

评估多种 α/β 骨架模式对功能性 α 螺旋模拟的影响:Bim BH3 结构域的类似物

Melissa D Boersma, Holly S Haase, Kimberly J Peterson-Kaufman, Erinna F Lee, Oliver B Clarke, Peter M Colman, Brian J Smith, W Seth Horne, W Douglas Fairlie, Samuel H Gellman