文献库，生知库 | 链接生命科学的每一步

Wilkins Rosanna J, Kannan Abirami, Plass Siobhan A, Wilson Claire, Kelly Richard D W, Tang Claire H M, Kotsantis Panagiotis, Reijns Martin A M, Kanhere Aditi, Petermann Eva

肿瘤

Human

肿瘤免疫

发表日期：2025

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Emerging roles of RNA:DNA hybrid regulation by mammalian ribonuclease H2 in replication stress and cancer

哺乳动物核糖核酸酶H2对RNA:DNA杂交体的调控在复制压力和癌症中的新兴作用

期刊:Journal of Cell Science

影响因子:3.6

doi:10.1242/jcs.264148

Wilkins, Rosanna J; Petermann, Eva

Mechanisms of Oncogene-Induced Replication Stress: Jigsaw Falling into Place

癌基因诱导复制应激的机制：拼图逐渐到位

期刊:Cancer Discovery

影响因子:33.3

doi:10.1158/2159-8290.CD-17-1461

Kotsantis, Panagiotis; Petermann, Eva; Boulton, Simon J

Targeted mutations in the ATR pathway define agent-specific requirements for cancer cell growth and survival

ATR通路中的靶向突变决定了癌细胞生长和存活所需的特定药物需求。

期刊:Molecular Cancer Therapeutics

影响因子:5.5

doi:10.1158/1535-7163.MCT-11-0675

Wilsker, Deborah; Chung, Jon H; Pradilla, Ivan; Petermann, Eva; Helleday, Thomas; Bunz, Fred

Hydroxyurea-stalled replication forks become progressively inactivated and require two different RAD51-mediated pathways for restart and repair.

羟基脲停滞的复制叉逐渐失活，需要两种不同的 RAD51 介导途径才能重新启动和修复

期刊:Molecular Cell

影响因子:16.6

doi:10.1016/j.molcel.2010.01.021

Petermann Eva, Orta Manuel LuÃs, Issaeva Natalia, Schultz Niklas, Helleday Thomas

RAD51

发表日期：2010

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PARP is activated at stalled forks to mediate Mre11-dependent replication restart and recombination

PARP在停滞的复制叉处被激活，以介导Mre11依赖的复制重启和重组。

期刊:EMBO Journal

影响因子:8.3

doi:10.1038/emboj.2009.206

Bryant, Helen E; Petermann, Eva; Schultz, Niklas; Jemth, Ann-Sofie; Loseva, Olga; Issaeva, Natalia; Johansson, Fredrik; Fernandez, Serena; McGlynn, Peter; Helleday, Thomas

Claspin promotes normal replication fork rates in human cells

Claspin促进人类细胞中正常的复制叉生成速率

期刊:Molecular Biology of the Cell

影响因子:2.7

doi:10.1091/mbc.e07-10-1035

Petermann, Eva; Helleday, Thomas; Caldecott, Keith W

细胞生物学

发表日期：2008

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Chk1 regulates the density of active replication origins during the vertebrate S phase

Chk1 调控脊椎动物 S 期活性复制起点的密度

期刊:EMBO Journal

影响因子:8.3

doi:10.1038/sj.emboj.7601714

Maya-Mendoza, Apolinar; Petermann, Eva; Gillespie, David A F; Caldecott, Keith W; Jackson, Dean A

信号转导

发表日期：2007

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ATR-dependent phosphorylation and activation of ATM in response to UV treatment or replication fork stalling

紫外线处理或复制叉停滞后，ATR依赖的ATM磷酸化和激活

期刊:EMBO Journal

影响因子:8.3

doi:10.1038/sj.emboj.7601446

Stiff, Thomas; Walker, Sarah A; Cerosaletti, Karen; Goodarzi, Aaron A; Petermann, Eva; Concannon, Pat; O'Driscoll, Mark; Jeggo, Penny A

Chk1 requirement for high global rates of replication fork progression during normal vertebrate S phase

Chk1对于正常脊椎动物S期高水平的复制叉推进至关重要

期刊:Molecular and Cellular Biology

影响因子:2.7

doi:10.1128/MCB.26.8.3319-3326.2006

Petermann, Eva; Maya-Mendoza, Apolinar; Zachos, George; Gillespie, David A F; Jackson, Dean A; Caldecott, Keith W

发表日期：2006

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Human RNase H2 upregulation counteracts oncogene- and chemotherapy-induced replication stress.

人类 RNase H2 上调可抵消癌基因和化疗引起的复制压力

Emerging roles of RNA:DNA hybrid regulation by mammalian ribonuclease H2 in replication stress and cancer

哺乳动物核糖核酸酶H2对RNA:DNA杂交体的调控在复制压力和癌症中的新兴作用

Mechanisms of Oncogene-Induced Replication Stress: Jigsaw Falling into Place

癌基因诱导复制应激的机制：拼图逐渐到位

Targeted mutations in the ATR pathway define agent-specific requirements for cancer cell growth and survival

ATR通路中的靶向突变决定了癌细胞生长和存活所需的特定药物需求。

Hydroxyurea-stalled replication forks become progressively inactivated and require two different RAD51-mediated pathways for restart and repair.

羟基脲停滞的复制叉逐渐失活，需要两种不同的 RAD51 介导途径才能重新启动和修复

PARP is activated at stalled forks to mediate Mre11-dependent replication restart and recombination

PARP在停滞的复制叉处被激活，以介导Mre11依赖的复制重启和重组。

Claspin promotes normal replication fork rates in human cells

Claspin促进人类细胞中正常的复制叉生成速率

Chk1 regulates the density of active replication origins during the vertebrate S phase

Chk1 调控脊椎动物 S 期活性复制起点的密度

ATR-dependent phosphorylation and activation of ATM in response to UV treatment or replication fork stalling

紫外线处理或复制叉停滞后，ATR依赖的ATM磷酸化和激活

Chk1 requirement for high global rates of replication fork progression during normal vertebrate S phase

Chk1对于正常脊椎动物S期高水平的复制叉推进至关重要