日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

RhoGEF12 regulates endosomal SORL1-retromer and its inhibition is therapeutic in human neuronal models of Alzheimer's disease.

RhoGEF12 调节内体 SORL1 逆转录酶,抑制 RhoGEF12 在阿尔茨海默病的人类神经元模型中具有治疗作用。

Qureshi Yasir H, Williams Charles A, Hajdu Istvan, Kannan Suvarnambiga, Govindarajan Ananya, Végh Barbara, Petsko Gregory A, Young Jessica E, Závodszky Péter, Small Scott A

The SORL1 p.Y1816C variant causes impaired endosomal dimerization and autosomal dominant Alzheimer's disease

SORL1 p.Y1816C 变异会导致内体二聚化受损和常染色体显性遗传性阿尔茨海默病。

Jensen, Anne Mette G; Raska, Jan; Fojtik, Petr; Monti, Giulia; Lunding, Melanie; Bartova, Simona; Pospisilova, Veronika; van der Lee, Sven J; Van Dongen, Jasper; Bossaerts, Liene; Van Broeckhoven, Christine; Dols-Icardo, Oriol; Lléo, Alberto; Bellini, Sonia; Ghidoni, Roberta; Hulsman, Marc; Petsko, Gregory A; Sleegers, Kristel; Bohaciakova, Dasa; Holstege, Henne; Andersen, Olav M

On the causal role of retromer-dependent endosomal recycling in Alzheimer's disease

关于逆转录酶依赖性内体循环在阿尔茨海默病中的因果作用

Young, Jessica E; Holstege, Henne; Andersen, Olav M; Petsko, Gregory A; Small, Scott A

Induced pluripotent stem cells: a tool for modeling Parkinson's disease

诱导多能干细胞:帕金森病建模的工具

Bose, Anindita; Petsko, Gregory A; Studer, Lorenz

Structural analysis of human CEACAM1 oligomerization

人类CEACAM1寡聚体的结构分析

Gandhi, Amit K; Sun, Zhen-Yu J; Huang, Yu-Hwa; Kim, Walter M; Yang, Chao; Petsko, Gregory A; Beauchemin, Nicole; Blumberg, Richard S

Structural basis of the dynamic human CEACAM1 monomer-dimer equilibrium

动态人CEACAM1单体-二聚体平衡的结构基础

Gandhi, Amit K; Sun, Zhen-Yu J; Kim, Walter M; Huang, Yu-Hwa; Kondo, Yasuyuki; Bonsor, Daniel A; Sundberg, Eric J; Wagner, Gerhard; Kuchroo, Vijay K; Petsko, Gregory A; Blumberg, Richard S

Seeing gene expression in cells: the future of structural biology

观察细胞中的基因表达:结构生物学的未来

Dai, Wei; Darst, Seth A; Dunham, Christine M; Landick, Robert; Petsko, Gregory; Weixlbaumer, Albert

Personalized iPSC-Derived Dopamine Progenitor Cells for Parkinson's Disease

用于治疗帕金森病的个性化iPSC衍生多巴胺祖细胞

Schweitzer, Jeffrey S; Song, Bin; Herrington, Todd M; Park, Tae-Yoon; Lee, Nayeon; Ko, Sanghyeok; Jeon, Jeha; Cha, Young; Kim, Kyungsang; Li, Quanzheng; Henchcliffe, Claire; Kaplitt, Michael; Neff, Carolyn; Rapalino, Otto; Seo, Hyemyung; Lee, In-Hee; Kim, Jisun; Kim, Taewoo; Petsko, Gregory A; Ritz, Jerome; Cohen, Bruce M; Kong, Sek-Won; Leblanc, Pierre; Carter, Bob S; Kim, Kwang-Soo

Endosomal recycling reconciles the Alzheimer's disease paradox

内体循环解决了阿尔茨海默病悖论

Small, Scott A; Petsko, Gregory A

High resolution X-ray and NMR structural study of human T-cell immunoglobulin and mucin domain containing protein-3

人类T细胞免疫球蛋白和粘蛋白结构域蛋白3的高分辨率X射线和核磁共振结构研究

Gandhi, Amit K; Kim, Walter M; Sun, Zhen-Yu J; Huang, Yu-Hwa; Bonsor, Daniel A; Sundberg, Eric J; Kondo, Yasuyuki; Wagner, Gerhard; Kuchroo, Vijay K; Petsko, Gregory; Blumberg, Richard S