日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Long-Term Outcomes of Patients With BRCA+ or PALB2+ Pancreatic Cancer Treated With Maintenance Rucaparib: A Secondary Analysis of a Nonrandomized Clinical Trial

接受 Rucaparib 维持治疗的 BRCA+ 或 PALB2+ 胰腺癌患者的长期疗效:一项非随机临床试验的二次分析

Reiss, Kim A; Xia, Mingyi; Akamandisa, Mwangala; D'Andrea, Kurt; Wubbenhorst, Brad; Lord, Christopher J; Pettitt, Stephen J; Tutt, Andrew N J; Brown, Timothy J; O'Hara, Mark H; Schneider, Charles; Teitelbaum, Ursina; Hannan, Zain; Hood, Ryan; Tondon, Rashmi; Vonderheide, Robert H; Domchek, Susan M; Nathanson, Katherine L

Tumour specific HORMAD1 expression perturbs mitotic arrest and drives sensitivity to mitotic kinase inhibitors.

肿瘤特异性 HORMAD1 表达扰乱有丝分裂停滞,并导致对有丝分裂激酶抑制剂的敏感性。

Walker Callum, Kollarovic Gabriel, Weekes Daniel, Trendell Jennifer, Hoffmann Ricarda M, Martin Alexia, Ferro Riccardo, Navarro-Llinas Blanca, Hitchen Luke, Pardo Calvo Mercedes, Balan Nicolae, Kemp Harriet, Carroll Alexandra, Davidson Kathryn, Nath Sarmi, D'Uonno Nadja, Lu Ruifang, Starling Chris, Otten Marieke, Iakobachvili Nino, Marcozzi Chiara, Rahman Ilhan, Quist Jelmar, Yu Lu, Krastev Dragomir B, Amodeo Valeria, Roxanis Ioannis, Grigoriadis Anita, Bayliss Richard, Choudhary Jyoti, Haider Syed, Pines Jonathon, Pettitt Stephen J, Lord Christopher J, Tutt Andrew N J

Correction to: Elevated APOBEC3B expression drives a kataegic-like mutation signature and replication stress-related therapeutic vulnerabilities in p53-defective cells

更正:APOBEC3B 表达升高驱动 p53 缺陷细胞中类似 kataegic 的突变特征和复制应激相关的治疗脆弱性

Nikkilä, Jenni; Kumar, Rahul; Campbell, James; Brandsma, Inger; Pemberton, Helen N; Wallberg, Fredrik; Nagy, Kinga; Scheer, Ildikó; Vertessy, Beata G; Serebrenik, Artur A; Monni, Valentina; Harris, Reuben S; Pettitt, Stephen J; Ashworth, Alan; Lord, Christopher J

The transcriptomic architecture of common cancers reflects synthetic lethal interactions

常见癌症的转录组结构反映了合成致死相互作用

Haider, Syed; Brough, Rachel; Madera, Santiago; Iacovacci, Jacopo; Gulati, Aditi; Wicks, Andrew; Alexander, John; Pettitt, Stephen J; Tutt, Andrew N J; Lord, Christopher J

Captured snapshots of PARP1 in the active state reveal the mechanics of PARP1 allostery.

捕捉到的 PARP1 活性状态快照揭示了 PARP1 变构的机制

Rouleau-Turcotte Élise, Krastev Dragomir B, Pettitt Stephen J, Lord Christopher J, Pascal John M

Identification of a Molecularly-Defined Subset of Breast and Ovarian Cancer Models that Respond to WEE1 or ATR Inhibition, Overcoming PARP Inhibitor Resistance

鉴定出对 WEE1 或 ATR 抑制剂有反应、克服 PARP 抑制剂耐药性的乳腺癌和卵巢癌模型中分子定义的亚群。

Serra, Violeta; Wang, Anderson T; Castroviejo-Bermejo, Marta; Polanska, Urszula M; Palafox, Marta; Herencia-Ropero, Andrea; Jones, Gemma N; Lai, Zhongwu; Armenia, Joshua; Michopoulos, Filippos; Llop-Guevara, Alba; Brough, Rachel; Gulati, Aditi; Pettitt, Stephen J; Bulusu, Krishna C; Nikkilä, Jenni; Wilson, Zena; Hughes, Adina; Wijnhoven, Paul W G; Ahmed, Ambar; Bruna, Alejandra; Gris-Oliver, Albert; Guzman, Marta; Rodríguez, Olga; Grueso, Judit; Arribas, Joaquin; Cortés, Javier; Saura, Cristina; Lau, Alan; Critchlow, Susan; Dougherty, Brian; Caldas, Carlos; Mills, Gordon B; Barrett, J Carl; Forment, Josep V; Cadogan, Elaine; Lord, Christopher J; Cruz, Cristina; Balmaña, Judith; O'Connor, Mark J

Resistance to DNA repair inhibitors in cancer

癌症中对DNA修复抑制剂的耐药性

Baxter, Joseph S; Zatreanu, Diana; Pettitt, Stephen J; Lord, Christopher J

Opinion: PARP inhibitors in cancer-what do we still need to know?

观点:PARP抑制剂在癌症治疗中的作用——我们还需要了解什么?

Wicks, Andrew J; Krastev, Dragomir B; Pettitt, Stephen J; Tutt, Andrew N J; Lord, Christopher J

Functional annotation of the 2q35 breast cancer risk locus implicates a structural variant in influencing activity of a long-range enhancer element

对 2q35 乳腺癌风险位点的功能注释表明,一个结构变异会影响长程增强子元件的活性。

Baxter, Joseph S; Johnson, Nichola; Tomczyk, Katarzyna; Gillespie, Andrea; Maguire, Sarah; Brough, Rachel; Fachal, Laura; Michailidou, Kyriaki; Bolla, Manjeet K; Wang, Qin; Dennis, Joe; Ahearn, Thomas U; Andrulis, Irene L; Anton-Culver, Hoda; Antonenkova, Natalia N; Arndt, Volker; Aronson, Kristan J; Augustinsson, Annelie; Becher, Heiko; Beckmann, Matthias W; Behrens, Sabine; Benitez, Javier; Bermisheva, Marina; Bogdanova, Natalia V; Bojesen, Stig E; Brenner, Hermann; Brucker, Sara Y; Cai, Qiuyin; Campa, Daniele; Canzian, Federico; Castelao, Jose E; Chan, Tsun L; Chang-Claude, Jenny; Chanock, Stephen J; Chenevix-Trench, Georgia; Choi, Ji-Yeob; Clarke, Christine L; Colonna, Sarah; Conroy, Don M; Couch, Fergus J; Cox, Angela; Cross, Simon S; Czene, Kamila; Daly, Mary B; Devilee, Peter; Dörk, Thilo; Dossus, Laure; Dwek, Miriam; Eccles, Diana M; Ekici, Arif B; Eliassen, A Heather; Engel, Christoph; Fasching, Peter A; Figueroa, Jonine; Flyger, Henrik; Gago-Dominguez, Manuela; Gao, Chi; García-Closas, Montserrat; García-Sáenz, José A; Ghoussaini, Maya; Giles, Graham G; Goldberg, Mark S; González-Neira, Anna; Guénel, Pascal; Gündert, Melanie; Haeberle, Lothar; Hahnen, Eric; Haiman, Christopher A; Hall, Per; Hamann, Ute; Hartman, Mikael; Hatse, Sigrid; Hauke, Jan; Hollestelle, Antoinette; Hoppe, Reiner; Hopper, John L; Hou, Ming-Feng; Ito, Hidemi; Iwasaki, Motoki; Jager, Agnes; Jakubowska, Anna; Janni, Wolfgang; John, Esther M; Joseph, Vijai; Jung, Audrey; Kaaks, Rudolf; Kang, Daehee; Keeman, Renske; Khusnutdinova, Elza; Kim, Sung-Won; Kosma, Veli-Matti; Kraft, Peter; Kristensen, Vessela N; Kubelka-Sabit, Katerina; Kurian, Allison W; Kwong, Ava; Lacey, James V; Lambrechts, Diether; Larson, Nicole L; Larsson, Susanna C; Le Marchand, Loic; Lejbkowicz, Flavio; Li, Jingmei; Long, Jirong; Lophatananon, Artitaya; Lubiński, Jan; Mannermaa, Arto; Manoochehri, Mehdi; Manoukian, Siranoush; Margolin, Sara; Matsuo, Keitaro; Mavroudis, Dimitrios; Mayes, Rebecca; Menon, Usha; Milne, Roger L; Mohd Taib, Nur Aishah; Muir, Kenneth; Muranen, Taru A; Murphy, Rachel A; Nevanlinna, Heli; O'Brien, Katie M; Offit, Kenneth; Olson, Janet E; Olsson, Håkan; Park, Sue K; Park-Simon, Tjoung-Won; Patel, Alpa V; Peterlongo, Paolo; Peto, Julian; Plaseska-Karanfilska, Dijana; Presneau, Nadege; Pylkäs, Katri; Rack, Brigitte; Rennert, Gad; Romero, Atocha; Ruebner, Matthias; Rüdiger, Thomas; Saloustros, Emmanouil; Sandler, Dale P; Sawyer, Elinor J; Schmidt, Marjanka K; Schmutzler, Rita K; Schneeweiss, Andreas; Schoemaker, Minouk J; Shah, Mitul; Shen, Chen-Yang; Shu, Xiao-Ou; Simard, Jacques; Southey, Melissa C; Stone, Jennifer; Surowy, Harald; Swerdlow, Anthony J; Tamimi, Rulla M; Tapper, William J; Taylor, Jack A; Teo, Soo Hwang; Teras, Lauren R; Terry, Mary Beth; Toland, Amanda E; Tomlinson, Ian; Truong, Thérèse; Tseng, Chiu-Chen; Untch, Michael; Vachon, Celine M; van den Ouweland, Ans M W; Wang, Sophia S; Weinberg, Clarice R; Wendt, Camilla; Winham, Stacey J; Winqvist, Robert; Wolk, Alicja; Wu, Anna H; Yamaji, Taiki; Zheng, Wei; Ziogas, Argyrios; Pharoah, Paul D P; Dunning, Alison M; Easton, Douglas F; Pettitt, Stephen J; Lord, Christopher J; Haider, Syed; Orr, Nick; Fletcher, Olivia

Structural basis for allosteric PARP-1 retention on DNA breaks

DNA断裂处PARP-1变构保留的结构基础

Zandarashvili, Levani; Langelier, Marie-France; Velagapudi, Uday Kiran; Hancock, Mark A; Steffen, Jamin D; Billur, Ramya; Hannan, Zain M; Wicks, Andrew J; Krastev, Dragomir B; Pettitt, Stephen J; Lord, Christopher J; Talele, Tanaji T; Pascal, John M; Black, Ben E