IL-13 decreases susceptibility to airway epithelial SARS-CoV-2 infection but increases disease severity in vivo via eicosanoid signalling
IL-13通过类花生酸信号通路降低气道上皮细胞对SARS-CoV-2感染的易感性,但增加体内疾病的严重程度。
期刊:EBioMedicine
影响因子:10.8
doi:10.1016/j.ebiom.2025.105920
Ghimire, Shreya; Xue, Biyun; Li, Kun; Gannon, Ryan M; Wohlford-Lenane, Christine L; Thurman, Andrew L; Gong, Huiyu; Necker, Grace C; Zheng, Jian; Meyerholz, David K; Perlman, Stanley; McCray, Paul B Jr; Pezzulo, Alejandro A
SARS-CoV-2
炎症/感染
信号转导
上皮细胞
IL-13
细胞生物学