日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Defining Functional Correction Thresholds in Primary Ciliary Dyskinesia for Effective Gene Therapies

确定原发性纤毛运动障碍功能矫正阈值以实现有效基因治疗

Fitzpatrick, Beck E; Wineinger, Brett J; Babcock, Jason E; Quiroz, Erik J; Liu, Emily C; Gautam, Lalit K; Pezzulo, Alejandro A; Moninger, Thomas O; Meyerholz, David K; Hornick, Douglas B; Ryan, Amy L

Porcine airway tissue explant culture at a hydrogel-air interface to model submucosal glands in cystic fibrosis progression and therapy

在水凝胶-空气界面上培养猪气道组织外植体,以模拟囊性纤维化进展和治疗中的黏膜下腺体。

Bierstedt, Kaleb C; Lin, Meng-Hsuan; Yu, Wenjie; Cooney, Ashley L; Goodell, Brian J; Gong, Huiyu; Pezzulo, Alejandro A; Sinn, Patrick L; Xie, Yuliang

IL-13 decreases susceptibility to airway epithelial SARS-CoV-2 infection but increases disease severity in vivo via eicosanoid signalling

IL-13通过类花生酸信号通路降低气道上皮细胞对SARS-CoV-2感染的易感性,但增加体内疾病的严重程度。

Ghimire, Shreya; Xue, Biyun; Li, Kun; Gannon, Ryan M; Wohlford-Lenane, Christine L; Thurman, Andrew L; Gong, Huiyu; Necker, Grace C; Zheng, Jian; Meyerholz, David K; Perlman, Stanley; McCray, Paul B Jr; Pezzulo, Alejandro A

Manual segmentation of opacities and consolidations on CT of long COVID patients from multiple annotators

多位标注者对新冠长期患者CT图像中的不透明区域和实变进行手动分割

Carmo, Diedre S; Pezzulo, Alejandro A; Villacreses, Raul A; Eisenbeisz, McKenna L; Anderson, Rachel L; Dorin, Sarah E Van; Rittner, Letícia; Lotufo, Roberto A; Gerard, Sarah E; Reinhardt, Joseph M; Comellas, Alejandro P

The extracellular matrix protein periostin is required for wound repair in primary human airway epithelia.

细胞外基质蛋白骨膜蛋白是人类原代呼吸道上皮细胞伤口修复所必需的

Tran Lorena A, Catlin Michael, Schecter Scott, Thurman Andrew L, Ghimire Shreya, Tudas Rosarie A, Bettis Brandon, Gannon Ryan M, Zabner Joseph, Pezzulo Alejandro A

Theratyping as a tool to guide clinical decision-making in patients with suspected cystic fibrosis and variants currently ineligible for CFTR modulator therapy

分型可作为指导临床决策的工具,用于疑似囊性纤维化且目前不适合接受 CFTR 调节剂治疗的变异患者。

Gannon, Ryan M; Wright, Brittany A; Bettis, Brandon A; Teresi, Mary E; Fischer, Anthony J; Weiner, Rebecca L; Peña, Tahuanty; Hornick, Douglas B; Thornell, Ian M; Rehman, Tayyab; Pezzulo, Alejandro A

Residential fungal β-(1,3)-D-glucan exposure is associated with decreased pulmonary function in fibrotic pulmonary sarcoidosis

居住环境中真菌β-(1,3)-D-葡聚糖的暴露与纤维化肺结节病患者的肺功能下降有关。

Stapleton, Emma M; Metwali, Nervana; Shlossman, Michael; Wendt, Linder; Pezzulo, Alejandro A; Hamzeh, Nabeel Y; Comellas, Alejandro P; Thorne, Peter S; Gerke, Alicia K

IL-13 induces loss of CFTR in ionocytes and reduces airway epithelial fluid absorption

IL-13诱导离子细胞中CFTR的丢失,并减少气道上皮液的吸收。

Romano Ibarra, Guillermo S; Lei, Lei; Yu, Wenjie; Thurman, Andrew L; Gansemer, Nicholas D; Meyerholz, David K; Pezzulo, Alejandro A; McCray, Paul B; Thornell, Ian M; Stoltz, David A

Epithelial responses to CFTR modulators are improved by inflammatory cytokines and impaired by antiinflammatory drugs

炎症细胞因子可增强上皮细胞对CFTR调节剂的反应,而抗炎药物则会削弱这种反应。

Rehman, Tayyab; Pezzulo, Alejandro A; Thurman, Andrew L; Zemans, Rachel L; Welsh, Michael J

Increased ENaC-mediated liquid absorption across vitamin-D deficient human airway epithelia.

维生素 D 缺乏的人呼吸道上皮细胞通过 ENaC 介导的液体吸收增加

Stapleton Emma M, Thurman Andrew L, Pezzulo Alejandro A, Comellas Alejandro P, Thornell Ian M