A Tiny Pocket Packs a Punch: Leveraging Pyridones for the Discovery of CNS-Penetrant Aza-indazole IRAK4 Inhibitors
微小口袋蕴藏强大能量:利用吡啶酮发现可穿透中枢神经系统的氮杂吲唑类IRAK4抑制剂
期刊:ACS Medicinal Chemistry Letters
影响因子:4
doi:10.1021/acsmedchemlett.4c00102
Bolduc, Philippe N; Pfaffenbach, Magnus; Evans, Ryan; Xin, Zhili; Henry, Kate L; Gao, Fang; Fang, Terry; Silbereis, John; Vera Rebollar, Jorge; Li, Pei; Chodaparambil, Jayanth V; Metrick, Claire; Peterson, Emily A