日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Extracellular vesicle-mediated release of bis(monoacylglycerol)phosphate is regulated by LRRK2 and glucocerebrosidase activity.

细胞外囊泡介导的双(单酰甘油)磷酸的释放受 LRRK2 和葡糖脑苷脂酶活性的调节。

Meneses-Salas Elsa, Castellá Moises, Arnold Marianna, Hsieh Frank, Fernández-Santiago Rubén, Ezquerra Mario, Garrido Alicia, Martí María-José, Enrich Carlos, Pfeffer Suzanne R, Merchant Kalpana, Lu Albert

GPNMB, LRRK2, and lysosome exocytosis in Parkinson's

帕金森病中的GPNMB、LRRK2和溶酶体胞吐作用

Pfeffer, Suzanne R

Endogenous LRRK2 and PINK1 function in a convergent neuroprotective ciliogenesis pathway in the brain

内源性LRRK2和PINK1在大脑中发挥着趋同的神经保护性纤毛发生通路的作用

Bagnoli, Enrico; Lin, Yu-En; Burel, Sophie; Jaimon, Ebsy; Antico, Odetta; Themistokleous, Christos; Nikoloff, Jonas M; Squires, Samuel; Morella, Ilaria; Watzlawik, Jens O; Fiesel, Fabienne C; Springer, Wolfdieter; Tonelli, Francesca; Lis, Pawel; Brooks, Simon P; Dunnett, Stephen B; Brambilla, Riccardo; Alessi, Dario R; Pfeffer, Suzanne R; Muqit, Miratul M K

Lysosomal glucocerebrosidase is needed for ciliary Hedgehog signaling: A convergent pathway contributing to Parkinson's disease.

溶酶体葡糖脑苷脂酶是纤毛 Hedgehog 信号传导所必需的:一条导致帕金森病的汇聚通路

Nair Sreeja V, Jaimon Ebsy, Adhikari Ayan, Nikoloff Jonas, Pfeffer Suzanne R

PPM1M, an LRRK2-counteracting, phosphoRab12-preferring phosphatase with a potential link to Parkinson's disease.

PPM1M 是一种 LRRK2 拮抗剂,优先结合磷酸化 Rab12 的磷酸酶,可能与帕金森病有关。

Chiang Claire Y, Pratuseviciute Neringa, Lin Yu-En, Adhikari Ayan, Yeshaw Wondwossen M, Flitton Chloe, Sherpa Pemba L, Tonelli Francesca, Rektorova Irena, Lynch Timothy, Siuda Joanna, Rudzińska-Bar Monika, Pulyk Oleksandr, Bauer Peter, Beetz Christian, Dickson Dennis W, Ross Owen A, Wszolek Zbigniew K, Fang Zih-Hua, Klein Christine, Zimprich Alexander, Alessi Dario R, Sammler Esther M, Pfeffer Suzanne R

Allosteric regulation of the Golgi-localized PPM1H phosphatase by Rab GTPases modulates LRRK2 substrate dephosphorylation in Parkinson's disease.

Rab GTP酶对高尔基体定位的PPM1H磷酸酶的变构调节可调控帕金森病中LRRK2底物的去磷酸化。

Adhikari Ayan, Tripathi Aashutosh, Chiang Claire Y, Sherpa Pemba, Pfeffer Suzanne R

Pathogenic LRRK2 mutations cause loss of primary cilia and Neurturin in striatal parvalbumin interneurons

致病性LRRK2突变导致纹状体小白蛋白中间神经元中纤毛和神经营养素的丢失

Lin, Yu-En; Jaimon, Ebsy; Tonelli, Francesca; Pfeffer, Suzanne R

End-product inhibition of the LRRK2-counteracting PPM1H phosphatase.

LRRK2拮抗剂PPM1H磷酸酶的终产物抑制

Adhikari Ayan, Tripathi Aashutosh, Chiang Claire Y, Sherpa Pemba, Pfeffer Suzanne R

NPC intracellular cholesterol transporter 1 (NPC1)-mediated cholesterol export from lysosomes

NPC 细胞内胆固醇转运蛋白 1 (NPC1) 介导的胆固醇从溶酶体输出

Pfeffer, Suzanne R

Rab GTPases: master regulators that establish the secretory and endocytic pathways

Rab GTP酶:建立分泌和内吞途径的关键调控因子

Pfeffer, Suzanne R