Dual inhibitors of thymidylate synthase and dihydrofolate reductase as antitumor agents: design, synthesis, and biological evaluation of classical and nonclassical pyrrolo[2,3-d]pyrimidine antifolates(1).

胸苷酸合成酶和二氢叶酸还原酶的双重抑制剂作为抗肿瘤药物：经典和非经典吡咯并[2,3-d]嘧啶抗叶酸的设计、合成和生物学评价(1)