日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Deep learning-enabled scaffolding of spatial arrays of PfCSP epitopes

利用深度学习构建 PfCSP 表位的空间阵列

Wu, Nelson R; Castro, Karla M; Beutler, Nathan; Lee, Wen-Hsin; Raghavan, Sai S R; Martin, Gregory M; Jain, Monika; Agrawal, Sashank; Liguori, Alessia; Kalyuzhniy, Oleksandr; Skog, Patrick D; Terada, Sierra; Lai, Yen-Chung; Ndihokubwayo, Justin; Lu, Danny; Eskandarzadeh, Saman; Alavi, Nushin; Phelps, Nicole; Tingle, Ryan; Youhanna, John E; Amirzehni, Sonya; Rogers, Thomas F; Burton, Dennis R; Wilson, Ian A; Ward, Andrew B; Correia, Bruno E; Schief, William R

mRNA delivery of circumsporozoite protein epitope-based malaria vaccines induces protection in a mouse model

利用mRNA递送基于环子孢子蛋白表位的疟疾疫苗可在小鼠模型中诱导保护作用

Wu, Nelson R; Beutler, Nathan; Hu, Xiaozhen; Skog, Patrick D; Liguori, Alessia; Flores-Garcia, Yevel; Maiorino, Laura; Terada, Sierra; Lu, Danny; Lai, Yen-Chung; Ndihokubwayo, Justin; Schiffner, Torben; Cottrell, Christopher A; Eskandarzadeh, Saman; Alavi, Nushin; Kubitz, Michael; Phelps, Nicole; Tingle, Ryan; Hodges, Sam; Youhanna, John E; Amirzehni, Sonya; Irvine, Darrell J; Himansu, Sunny; Zavala, Fidel; Rogers, Thomas F; Burton, Dennis R; Schief, William R

Antigen avidity drives the durability of the vaccine immune response

抗原亲和力决定了疫苗免疫反应的持久性

Weidner, Nicole G; Padilla, Mauricio V; Pruitt, Layne; Cottrell, Christopher A; Gonzales, Kristyn; Kalyuzhniy, Oleksandr; Kubitz, Michael; Alavi, Nushin; Phelps, Nicole; Weglarz, Meredith; Schief, William R; Abbott, Robert K

Vaccination with mRNA-encoded membrane-anchored HIV envelope trimers elicited tier 2 neutralizing antibodies in a phase 1 clinical trial

在一项 I 期临床试验中,接种 mRNA 编码的膜锚定 HIV 包膜三聚体疫苗可诱导产生 2 级中和抗体。

Parks, K Rachael; Moodie, Zoe; Allen, Mary A; Yen, Catherine; Furch, Briana D; MacPhee, Kellie J; Ozorowski, Gabriel; Heptinstall, Jack; Hahn, William O; Zheng, Zihan; Lu, Huiyin; Grant, Shannon; Domin, Elize; Duff, Michael O; Seese, Aaron; Marini-Macouzet, Constanza; Ballweber-Fleming, Lamar; Lee, Wen-Hsin; Cottrell, Christopher A; Liguori, Alessia; Georgeson, Erik; Alavi, Nushin; Kubitz, Michael; Phelps, Nicole; Seaton, Kelly E; Cohen, Kristen W; Anderson, Maija A; Mondal, Kajari; Laufer, Dagna S; Kublin, James G; Ward, Andrew B; Hyrien, Ollivier; De Rosa, Stephen C; Himansu, Sunny; Leav, Brett; Reuter, Caroline; Tomaras, Georgia D; Montefiori, David; Walsh, Stephen R; Frank, Ian; Sobieszczyk, Magdalena E; Goepfert, Paul A; Stephenson, Kathryn E; Baden, Lindsey R; Van Tieu, Hong; Keefer, Michael C; Clark, Jesse; Riddler, Sharon A; Schief, William R; McElrath, M Juliana

Antibody feedback establishes an affinity brake in the germinal center.

抗体反馈在生发中心建立亲和力抑制机制。

Yan Yu, Wang Xuesong, Xie Zhenfei, Bader Daniel L V, Lim Ryan H, Ma Krystal M, Cottrell Christopher A, Steichen Jon M, Xu Liling, Villavicencio Paula Maldonado, Akauliya Madhav, Koo Ja-Hyun, Shen Jacqueline Ming, Vernich Alexandra, Kalyuzhniy Oleksandr, Allen Joel D, Albowaidey Ali A, Alicea Anthony, Chen Bingxian, Georgeson Erik, Ellis-Pugh Jordan Renae, Alavi Nushin, Esposito Abigail, Naili Hannah, Phelps Nicole, Kelley Brendon, Kubitz Michael, Phan Quynh Anh, Liguori Alessia, Prum Thavaleak, Tingle Ryan, Lu Danny, Eskandarzadeh Saman, Liu Xiaotie, Warner John E, Weldon Stephanie R, Himansu Sunny, Crispin Max, Nair Usha, Liu Sophia, Schief William R, Batista Facundo D

Vaccination with mRNA-encoded membrane-bound HIV Envelope trimer induces neutralizing antibodies in animal models.

用 mRNA 编码的膜结合 HIV 包膜三聚体进行疫苗接种,可在动物模型中诱导中和抗体

Ramezani-Rad Parham, Cottrell Christopher A, Marina-Zárate Ester, Liguori Alessia, Landais Elise, Torres Jonathan L, Myers Amber, Lee Jeong Hyun, Baboo Sabyasachi, Flynn Claudia, McKenney Katherine, Salcedo Eugenia, Zhou Xiaoya, Kalyuzhniy Oleksandr, Georgeson Erik, Phelps Nicole, Lu Danny, Eskandarzadeh Saman, Menis Sergey, Kubitz Michael, Groschel Bettina, Alavi Nushin, Jackson Abigail M, Lee Wen-Hsin, Tran Andy S, Ben-Akiva Elana, Michaels Katarzyna Kaczmarek, Diedrich Jolene K, Enemuo Chiamaka A, Lewis Vanessa, Pradhan Arpan, Kasturi Sudhir Pai, Schiffner Torben, Steichen Jon M, Carnathan Diane G, Himansu Sunny, Yates John R 3rd, Paulson James C, Ozorowski Gabriel, Irvine Darrell J, Silvestri Guido, Sok Devin, Ward Andrew B, Crotty Shane, Schief William R

CryoEM Structures of Antibodies Elicited by Germline-Targeting HIV MPER Epitope-Scaffolds.

针对生殖系 HIV MPER 表位支架诱导产生的抗体的冷冻电镜结构

Huang Jiachen, Swanson Olivia M, Rantalainen Kimmo, Fernández-Quintero Monica L, Loeffler Johannes R, Tingle Ryan, Georgeson Erik, Phelps Nicole, Ozorowski Gabriel, Schiffner Torben, Schief William R, Ward Andrew B

Author Correction: Vaccination induces broadly neutralizing antibody precursors to HIV gp41

作者更正:接种疫苗可诱导产生针对 HIV gp41 的广谱中和抗体前体

Schiffner, Torben; Phung, Ivy; Ray, Rashmi; Irimia, Adriana; Tian, Ming; Swanson, Olivia; Lee, Jeong Hyun; Lee, Chang-Chun D; Marina-Zárate, Ester; Cho, So Yeon; Huang, Jiachen; Ozorowski, Gabriel; Skog, Patrick D; Serra, Andreia M; Rantalainen, Kimmo; Allen, Joel D; Baboo, Sabyasachi; Rodriguez, Oscar L; Himansu, Sunny; Zhou, Jianfu; Hurtado, Jonathan; Flynn, Claudia T; McKenney, Katherine; Havenar-Daughton, Colin; Saha, Swati; Shields, Kaitlyn; Schultze, Steven; Smith, Melissa L; Liang, Chi-Hui; Toy, Laura; Pecetta, Simone; Lin, Ying-Cing; Willis, Jordan R; Sesterhenn, Fabian; Kulp, Daniel W; Hu, Xiaozhen; Cottrell, Christopher A; Zhou, Xiaoya; Ruiz, Jennifer; Wang, Xuesong; Nair, Usha; Kirsch, Kathrin H; Cheng, Hwei-Ling; Davis, Jillian; Kalyuzhniy, Oleksandr; Liguori, Alessia; Diedrich, Jolene K; Ngo, Julia T; Lewis, Vanessa; Phelps, Nicole; Tingle, Ryan D; Spencer, Skye; Georgeson, Erik; Adachi, Yumiko; Kubitz, Michael; Eskandarzadeh, Saman; Elsliger, Marc A; Amara, Rama R; Landais, Elise; Briney, Bryan; Burton, Dennis R; Carnathan, Diane G; Silvestri, Guido; Watson, Corey T; Yates, John R 3rd; Paulson, James C; Crispin, Max; Grigoryan, Gevorg; Ward, Andrew B; Sok, Devin; Alt, Frederick W; Wilson, Ian A; Batista, Facundo D; Crotty, Shane; Schief, William R

mRNA-LNP prime boost evolves precursors toward VRC01-like broadly neutralizing antibodies in preclinical humanized mouse models

mRNA-LNP 启动增强作用在临床前人源化小鼠模型中诱导产生类似 VRC01 的广谱中和抗体的前体。

Wang, Xuesong; Cottrell, Christopher A; Hu, Xiaozhen; Ray, Rashmi; Bottermann, Maria; Villavicencio, Paula Maldonado; Yan, Yu; Xie, Zhenfei; Warner, John E; Ellis-Pugh, Jordan Renae; Kalyuzhniy, Oleksandr; Liguori, Alessia; Willis, Jordan R; Menis, Sergey; Rämisch, Sebastian; Eskandarzadeh, Saman; Kubitz, Michael; Tingle, Ryan; Phelps, Nicole; Groschel, Bettina; Himansu, Sunny; Carfi, Andrea; Kirsch, Kathrin H; Weldon, Stephanie R; Nair, Usha; Schief, William R; Batista, Facundo D

Diverse priming outcomes under conditions of very rare precursor B cells.

在极少数前体 B 细胞条件下,出现了多种不同的启动结果。

Madden Patrick J, Marina-Zárate Ester, Rodrigues Kristen A, Steichen Jon M, Shil Monolina, Ni Kaiyuan, Michaels Katarzyna Kaczmarek, Maiorino Laura, Upadhyay Amit A, Saha Swati, Pradhan Arpan, Kalyuzhiny Oleksandr, Liguori Alessia, Lopez Paul G, Phung Ivy, Phelps Nicole, Georgeson Erik, Alavi Nushin, Kubitz Michael, Lu Danny, Eskandarzadeh Saman, Metz Amanda, Rodriguez Oscar L, Shields Kaitlyn, Schultze Steven, Smith Melissa L, Healy Brandon S, Lim Deuk, Lewis Vanessa R, Ben-Akiva Elana, Pinney William 3rd, Gregory Justin, Xiao Shuhao, Carnathan Diane G, Kasturi Sudhir Pai, Watson Corey T, Bosinger Steven E, Silvestri Guido, Schief William R, Irvine Darrell J, Crotty Shane