日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Binimetinib and encorafenib for the treatment of advanced solid tumors with non-V600E BRAF mutations: results from the Phase II BEAVER trial

比美替尼和恩科拉非尼治疗携带非V600E BRAF突变的晚期实体瘤:来自II期BEAVER试验的结果

April A N Rose #,Jennifer Maxwell #,Emmanuelle Rousselle #,Chantel L Mukonoweshuro,Islam E Elkholi,Melody Riaud,Marco Biondini,Erica Cianfarano,Isabel Soria-Bretones,Chantal Tobin,Meghan McGuire,Rhoda W Y Law,Andrew J Elia,Ben X Wang,Ian King,Tong Zhang,Trevor J Pugh,Zaid Saeed Kamil,Marcus Butler,Frances A Shepherd,Natasha B Leighl,Albiruni Abdul Razak,Aaron Hansen,Samuel D Saibil,Philippe L Bedard,Peter M Siegel,Lillian L Siu,David W Cescon,Anna Spreafico

PI3Kα Inhibitor and Degrader Inavolisib Can Co-opt FGFR2 to Enhance Responses in Patients with PIK3CA-Mutated Solid Tumors and in Preclinical Models.

PI3Kα抑制剂和降解剂Inavolisib可利用FGFR2增强PIK3CA突变实体瘤患者和临床前模型的疗效。

Juric Dejan, Song Kyung, Johnson Radia M, Accordino Melissa K, Bedard Philippe L, Cervantes Andrés, Gambardella Valentina, Hamilton Erika, Italiano Antoine, Kalinsky Kevin, Krop Ian E, Oliveira Mafalda, Saura Cristina, Schmid Peter, Turner Nicholas C, Varga Andreea, Gendreau Steven, Hwang Michael S, Kuang Zheng, Lau Jeffrey T, Lin Eva, Pham Trang, Maddalo Danilo, Rees Matthew G, Ronan Melissa M, Roth Jennifer A, Martin Scott, Sodir Nicole M, Sokol Ethan S, Whitfield Zachary J, Wong Alice, Yauch Robert L, Aimi Junko, Cheeti Sravanthi, Fredrickson Jill, Hilz Stephanie, Hafner Marc, Hutchinson Katherine E, Jin Yanling, Peters Ubong, Zingg Daniel, Royer-Joo Stephanie, Shankar Noopur, Schutzman Jennifer L, Jhaveri Komal L, Dey Anwesha

Clinical validation of a tissue-agnostic genome-wide methylome enrichment assay to monitor response to pembrolizumab

组织非特异性全基因组甲基化组富集检测方法的临床验证,用于监测帕博利珠单抗的疗效

Stutheit-Zhao, Eric Y; Zhong, Yongqi; Melton, Collin A; Lightbody, Elizabeth D; Hinterberg, Michael A; Wang, Yarong; Hall, Owen; Sosa, Eduardo V; Provance, Jeremy B; Zhang, Junjun; Licon, Abel; Liu, Zhihui Amy; Abdul Razak, Albiruni R; Spreafico, Anna; Bedard, Philippe L; Hansen, Aaron R; Lheureux, Stephanie; Ohashi, Pamela S; Williams, Alan; Bratman, Scott V; Allen, Brian A; Zhang, Jing; De Carvalho, Daniel D; Hartman, Anne-Renee; Siu, Lillian L; Sanz-Garcia, Enrique

Development and psychometric properties of the 'Assessment of Burden of Chronic Conditions (ABCC) tool' for people with chronic heart failure (CHF): a mixed methods approach

慢性心力衰竭(CHF)患者“慢性疾病负担评估(ABCC)工具”的开发和心理测量特性:一种混合方法

Keijsers, Lotte C E M; Peters, Loraine H L; van Schayck, Onno C P; Muris, Jean W M; Boudewijns, Esther A; Claessens, Danny; Willemsen, Robert T A; Salomé, Philippe L; Boyne, Josiane J J; Brunner-La Rocca, Hans-Peter; van Pol, Petra E J; Jaarsma, Tiny; Chavannes, Niels H; Bonten, Tobias N; Gidding-Slok, Annerika H M

Beamion PANTUMOR-1: rationale and design of a Phase II trial of zongertinib in HER2-overexpressed/amplified or HER2-mutant solid tumors

Beamion PANTUMOR-1:zongertinib治疗HER2过表达/扩增或HER2突变实体瘤的II期试验的理论依据和设计

Schram, Alison M; Park, John J; Italiano, Antoine; Kitano, Shigehisa; Guo, Ye; Li, Jin; Bedard, Philippe L; van Marcke, Cedric; Ko, Ryo; Lunger, Lukas; Klotz, Daniel M; Hussain, Jo; Maier, Daniela; Erzen, Damijan; Planchard, David; Prenen, Hans; Clay, Timothy D; Park, Joon O; Kim, Hyung-Don; Hernando-Calvo, Alberto; Maruki, Yuta; Ponz-Sarvise, Mariano; Dumbrava, Ecaterina

Large-scale genome-wide association analyses identify novel genetic loci and mechanisms in hypertrophic cardiomyopathy

大规模全基因组关联分析揭示肥厚型心肌病的新遗传位点和机制

Tadros, Rafik; Zheng, Sean L; Grace, Christopher; Jordà, Paloma; Francis, Catherine; West, Dominique M; Jurgens, Sean J; Thomson, Kate L; Harper, Andrew R; Ormondroyd, Elizabeth; Xu, Xiao; Theotokis, Pantazis I; Buchan, Rachel J; McGurk, Kathryn A; Mazzarotto, Francesco; Boschi, Beatrice; Pelo, Elisabetta; Lee, Michael; Noseda, Michela; Varnava, Amanda; Vermeer, Alexa M C; Walsh, Roddy; Amin, Ahmad S; van Slegtenhorst, Marjon A; Roslin, Nicole M; Strug, Lisa J; Salvi, Erika; Lanzani, Chiara; de Marvao, Antonio; Roberts, Jason D; Tremblay-Gravel, Maxime; Giraldeau, Genevieve; Cadrin-Tourigny, Julia; L'Allier, Philippe L; Garceau, Patrick; Talajic, Mario; Gagliano Taliun, Sarah A; Pinto, Yigal M; Rakowski, Harry; Pantazis, Antonis; Bai, Wenjia; Baksi, John; Halliday, Brian P; Prasad, Sanjay K; Barton, Paul J R; O'Regan, Declan P; Cook, Stuart A; de Boer, Rudolf A; Christiaans, Imke; Michels, Michelle; Kramer, Christopher M; Ho, Carolyn Y; Neubauer, Stefan; Matthews, Paul M; Wilde, Arthur A M; Tardif, Jean-Claude; Olivotto, Iacopo; Adler, Arnon; Goel, Anuj; Ware, James S; Bezzina, Connie R; Watkins, Hugh

Randomized Phase II Study of Bevacizumab with Weekly Anetumab Ravtansine or Weekly Paclitaxel in Platinum-Resistant/Refractory High-Grade Ovarian Cancer (NCI Trial)

贝伐珠单抗联合每周一次阿奈妥单抗或每周一次紫杉醇治疗铂类耐药/难治性高级别卵巢癌的随机 II 期研究(NCI 试验)

Alqaisi, Husam A; Cohn, David E; Chern, Jing-Yi; Duska, Linda R; Jewell, Andrea; Corr, Bradley R; Winer, Ira Seth; Girda, Eugenia; Crispens, Marta A; Dhani, Neesha C; Madariaga, Ainhoa; Grant, Robert C; Malaguti, Matthew; Lee, Crystal; Bowering, Valerie; Wong, Horace; Poothullil, Andrew; Speers, Vanessa; Wang, Lisa; Bedard, Philippe L; Brady, John C; Nixon, Andrew B; Chen, Li; O'Connor, Claire; Zamboni, William; McKee, Tawyna; Moscow, Jeffrey A; Oza, Amit M; Lheureux, Stephanie

Ultrasensitive Detection and Monitoring of Circulating Tumor DNA Using Structural Variants in Early-Stage Breast Cancer

利用结构变异对早期乳腺癌循环肿瘤DNA进行超灵敏检测和监测

Elliott, Mitchell J; Howarth, Karen; Main, Sasha; Fuentes Antrás, Jesús; Echelard, Philippe; Dou, Aaron; Amir, Eitan; Nadler, Michelle B; Shah, Elizabeth; Yu, Celeste; Bratman, Scott; Bird, Taylor; Roh, June; de Bruin, Elza C; Rushton, Christopher; Chen, Yilun; Gladchuk, Sergii; George, Anthony M; Birkeälv, Sofia; Alcaide, Miguel; Oton, Lucia; Putcha, Girish; Woodhouse, Samuel; Bedard, Philippe L; Siu, Lillian L; Berman, Hal K; Cescon, David W

Phase I Clinical Trial of the Bifunctional EGFR/TGF-β Fusion Protein Ficerafusp Alfa (BCA101) Alone and in Combination with Pembrolizumab for Advanced Solid Tumors

双功能 EGFR/TGF-β 融合蛋白 Ficerafusp Alfa (BCA101) 单药及联合帕博利珠单抗治疗晚期实体瘤的 I 期临床试验

Hernando-Calvo, Alberto; Carvajal, Richard D; Paik, Paul K; Morris, Van Karlyle; Zandberg, Dan P; Kaczmar, John M; Bohr, David N; Reiners, Ralf D; Gharakhani, Elham; Salazar, Rachel L; Lizotte, Patrick Hall; Ivanova, Elena V; Bedard, Philippe L; Hanna, Glenn J

Advancing equitable access to innovation in breast cancer

促进乳腺癌创新成果的公平获取

O'Reilly, Seamus; Luis, Ines Vaz; Adam, Virginie; Razis, Evangelia D; Urruticoechea, Ander; Arahmani, Amal; Carrasco, Eva; Chua, Boon H; Bliss, Judith; Straehle, Carolyn; Goulioti, Theodora; Lindholm, Barbro; Werutsky, Gustavo; Brain, Etienne; Bedard, Philippe L; Curigliano, Giuseppe; Loi, Sherene; Saji, Shigehira; Cameron, David