日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Mutant p53 exploits enhancers to elevate immunosuppressive chemokine expression and impair immune checkpoint inhibitors in pancreatic cancer

突变型p53利用增强子提高免疫抑制性趋化因子的表达,并削弱胰腺癌中的免疫检查点抑制剂的作用。

Dig B Mahat ,Heena Kumra ,Sarah A Castro ,Emily Metcalf ,Kim Nguyen ,Ryo Morisue ,William W Ho ,Ivy Chen ,Brandon Sullivan ,Leon H Yim ,Arundeep Singh ,Jiayu Fu ,Sean K Waterton ,Yu-Chi Cheng ,Enrico Moiso ,Vikash P Chauhan ,Hernandez Moura Silva ,Stefani Spranger ,Rakesh K Jain ,Phillip A Sharp

Single-cell nascent RNA sequencing unveils coordinated global transcription

单细胞新生RNA测序揭示协调的全局转录

Dig B Mahat, Nathaniel D Tippens, Jorge D Martin-Rufino, Sean K Waterton, Jiayu Fu, Sarah E Blatt, Phillip A Sharp

Single-cell nascent RNA sequencing using click-chemistry unveils coordinated transcription

利用点击化学进行单细胞新生 RNA 测序揭示协调转录

Dig B Mahat, Nathaniel D Tippens, Jorge D Martin-Rufino, Sean K Waterton, Jiayu Fu, Sarah E Blatt, Phillip A Sharp

Transcription factor antagonism regulates heterogeneity in embryonic stem cell states

转录因子拮抗作用调节胚胎干细胞状态的异质性

Sofia Hu, Emily Metcalf, Dig Bijay Mahat, Lynette Chan, Noor Sohal, Meenakshi Chakraborty, Maxwell Hamilton, Arundeep Singh, Abhyudai Singh, Jacqueline A Lees, Phillip A Sharp, Salil Garg

RNA-Mediated Feedback Control of Transcriptional Condensates

RNA 介导的转录凝聚物的反馈控制

Jonathan E Henninger, Ozgur Oksuz, Krishna Shrinivas, Ido Sagi, Gary LeRoy, Ming M Zheng, J Owen Andrews, Alicia V Zamudio, Charalampos Lazaris, Nancy M Hannett, Tong Ihn Lee, Phillip A Sharp, Ibrahim I Cissé, Arup K Chakraborty, Richard A Young

Imprinted Maternally Expressed microRNAs Antagonize Paternally Driven Gene Programs in Neurons

印迹母系表达的 microRNA 拮抗神经元中父系驱动的基因程序

Amanda J Whipple, Vincent Breton-Provencher, Hannah N Jacobs, Udbhav K Chitta, Mriganka Sur, Phillip A Sharp

Pol II phosphorylation regulates a switch between transcriptional and splicing condensates

RNA聚合酶II磷酸化调节转录凝聚体和剪接凝聚体之间的转换

Yang Eric Guo # ,John C Manteiga # ,Jonathan E Henninger ,Benjamin R Sabari ,Alessandra Dall'Agnese ,Nancy M Hannett ,Jan-Hendrik Spille ,Lena K Afeyan ,Alicia V Zamudio ,Krishna Shrinivas ,Brian J Abraham ,Ann Boija ,Tim-Michael Decker ,Jenna K Rimel ,Charli B Fant ,Tong Ihn Lee ,Ibrahim I Cisse ,Phillip A Sharp ,Dylan J Taatjes ,Richard A Young

Enhancer Features that Drive Formation of Transcriptional Condensates

促进转录凝聚物形成的增强子特征

Krishna Shrinivas, Benjamin R Sabari, Eliot L Coffey, Isaac A Klein, Ann Boija, Alicia V Zamudio, Jurian Schuijers, Nancy M Hannett, Phillip A Sharp, Richard A Young, Arup K Chakraborty

CDK12 regulates DNA repair genes by suppressing intronic polyadenylation

CDK12 通过抑制内含子多聚腺苷酸化来调节 DNA 修复基因

Sara J Dubbury, Paul L Boutz, Phillip A Sharp

Deconvolution of seed and RNA-binding protein crosstalk in RNAi-based functional genomics

基于 RNAi 的功能基因组学中种子和 RNA 结合蛋白串扰的反卷积

Hiroshi I Suzuki, Ryan M Spengler, Giedre Grigelioniene, Tatsuya Kobayashi, Phillip A Sharp