日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Pervasive Divergence in Protein Thermostability is Mediated by Both Structural Changes and Cellular Environments

蛋白质热稳定性的普遍差异是由结构变化和细胞环境共同介导的。

Walunjkar, Nilima; Lai, Timothy Y; Akhter, Nasima; Miller, James H; Bettinger, John Q; Marcus, Erin; Phizicky, Eric M; Ghaemmaghami, Sina; Fay, Justin C

Schizosaccharomyces pombe pus1 mutants are temperature sensitive due to decay of tRNA(Ile(UAU)) by the 5'-3' exonuclease Dhp1, primarily targeting the unspliced pre-tRNA

裂殖酵母pus1突变体对温度敏感,这是由于5'-3'外切核酸酶Dhp1降解tRNA(Ile(UAU))所致,该酶主要靶向未剪接的前体tRNA。

Stegemann, Franziska; Marcus, Erin; Neupert, Savanah; Ostrowski, Sarah; Mathews, David H; Phizicky, Eric M

Phosphorylation of the nuclear poly(A) binding protein (PABPN1) during mitosis protects mRNA from hyperadenylation and maintains transcriptome dynamics

有丝分裂期间核聚腺苷酸结合蛋白 (PABPN1) 的磷酸化可保护 mRNA 免于过度腺苷酸化并维持转录组动力学

Jackson M Gordon, David V Phizicky, Leonard Schärfen, Courtney L Brown, Dahyana Arias Escayola, Jean Kanyo, TuKiet T Lam, Matthew D Simon, Karla M Neugebauer

The life and times of a tRNA

tRNA 的一生

Phizicky, Eric M; Hopper, Anita K

Initiator tRNA lacking 1-methyladenosine is targeted by the rapid tRNA decay pathway in evolutionarily distant yeast species

在进化上较远的酵母物种中,缺乏 1-甲基腺苷的启动 tRNA 是快速 tRNA 衰变途径的靶标

Monika Tasak, Eric M Phizicky

Nuclear mechanisms of gene expression control: pre-mRNA splicing as a life or death decision

基因表达调控的核机制:前体mRNA剪接作为生死抉择

Gordon, Jackson M; Phizicky, David V; Neugebauer, Karla M

Mutations in the anticodon stem of tRNA cause accumulation and Met22-dependent decay of pre-tRNA in yeast

酵母中tRNA反密码子茎的突变会导致前体tRNA的积累和Met22依赖性降解。

Payea, Matthew J; Hauke, Alayna C; De Zoysa, Thareendra; Phizicky, Eric M

Hypomodified tRNA in evolutionarily distant yeasts can trigger rapid tRNA decay to activate the general amino acid control response, but with different consequences

在进化上相距甚远的酵母中,低修饰的tRNA可以触发tRNA的快速降解,从而激活一般的氨基酸调控反应,但其后果却有所不同。

De Zoysa, Thareendra; Phizicky, Eric M

PUS7 mutations impair pseudouridylation in humans and cause intellectual disability and microcephaly

PUS7基因突变会损害人类的假尿苷化作用,并导致智力障碍和小头畸形。

Shaheen, Ranad; Tasak, Monika; Maddirevula, Sateesh; Abdel-Salam, Ghada M H; Sayed, Inas S M; Alazami, Anas M; Al-Sheddi, Tarfa; Alobeid, Eman; Phizicky, Eric M; Alkuraya, Fowzan S

Formation of tRNA Wobble Inosine in Humans Is Disrupted by a Millennia-Old Mutation Causing Intellectual Disability

人类 tRNA 摆动肌苷的形成因千年历史的突变而中断,导致智力障碍

Jillian Ramos, Lu Han, Yan Li, Felix Hagelskamp, Stefanie M Kellner, Fowzan S Alkuraya, Eric M Phizicky, Dragony Fu