日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Correction: Hsf1 and the molecular chaperone Hsp90 support a 'rewiring stress response' leading to an adaptive cell size increase in chronic stress

更正:Hsf1 和分子伴侣 Hsp90 支持“重编程应激反应”,从而导致慢性应激下细胞体积的适应性增大。

Maiti, Samarpan; Bhattacharya, Kaushik; Wider, Diana; Hany, Dina; Panasenko, Olesya; Bernasconi, Lilia; Hulo, Nicolas; Picard, Didier

A white paper from the FEBS Education and Training Conference: challenges, opportunities, and action plans for transforming molecular life sciences education

FEBS教育与培训会议白皮书:分子生命科学教育转型面临的挑战、机遇和行动计划

Villo, Ly; Sincic, Nino; Mello, Luciane V; Costa, Manuel Joao; Picard, Didier; Malatesta, Francesco; Dumic, Jerka; Sagin, Ferhan G

The Hsp70-Hsp90 go-between Hop/Stip1/Sti1 is a proteostatic switch and may be a drug target in cancer and neurodegeneration

Hsp70-Hsp90之间的中间体Hop/Stip1/Sti1是一种蛋白质稳态开关,可能成为癌症和神经退行性疾病的药物靶点。

Bhattacharya, Kaushik; Picard, Didier

Dynamic Imaging of LDH Inhibition in Tumors Reveals Rapid In Vivo Metabolic Rewiring and Vulnerability to Combination Therapy.

动态成像显示肿瘤中 LDH 抑制可导致体内代谢快速重编程,并对联合疗法产生敏感性

Oshima Nobu, Ishida Ryo, Kishimoto Shun, Beebe Kristin, Brender Jeffrey R, Yamamoto Kazutoshi, Urban Daniel, Rai Ganesha, Johnson Michelle S, Benavides Gloria, Squadrito Giuseppe L, Crooks Dan, Jackson Joseph, Joshi Abhinav, Mott Bryan T, Shrimp Jonathan H, Moses Michael A, Lee Min-Jung, Yuno Akira, Lee Tobie D, Hu Xin, Anderson Tamara, Kusewitt Donna, Hathaway Helen H, Jadhav Ajit, Picard Didier, Trepel Jane B, Mitchell James B, Stott Gordon M, Moore William, Simeonov Anton, Sklar Larry A, Norenberg Jeffrey P, Linehan W Marston, Maloney David J, Dang Chi V, Waterson Alex G, Hall Matthew, Darley-Usmar Victor M, Krishna Murali C, Neckers Leonard M

Genetic Ablation of MiR-22 Fosters Diet-Induced Obesity and NAFLD Development

miR-22基因缺失促进饮食诱导的肥胖和非酒精性脂肪性肝病的发展

Gjorgjieva, Monika; Sobolewski, Cyril; Ay, Anne-Sophie; Abegg, Daniel; Correia de Sousa, Marta; Portius, Dorothea; Berthou, Flavien; Fournier, Margot; Maeder, Christine; Rantakari, Pia; Zhang, Fu-Ping; Poutanen, Matti; Picard, Didier; Montet, Xavier; Nef, Serge; Adibekian, Alexander; Foti, Michelangelo

Methods to validate Hsp90 inhibitor specificity, to identify off-target effects, and to rethink approaches for further clinical development

验证Hsp90抑制剂特异性、识别脱靶效应以及重新思考后续临床开发方法的策略

Neckers, Len; Blagg, Brian; Haystead, Timothy; Trepel, Jane B; Whitesell, Luke; Picard, Didier

Secreted dual reporter assay with Gaussia luciferase and the red fluorescent protein mCherry

利用高斯荧光素酶和红色荧光蛋白mCherry进行分泌型双报告基因检测

Wider, Diana; Picard, Didier

Minireview: Tipping the balance: ligand-independent activation of steroid receptors

小综述:打破平衡:类固醇受体的配体非依赖性激活

Bennesch, Marcela A; Picard, Didier

Mitochondrial oxidative phosphorylation TRAP(1)ped in tumor cells

肿瘤细胞中的线粒体氧化磷酸化TRAP(1)ped

Rasola, Andrea; Neckers, Len; Picard, Didier

Dynamic impacts of the inhibition of the molecular chaperone Hsp90 on the T-cell proteome have implications for anti-cancer therapy.

抑制分子伴侣 Hsp90 对 T 细胞蛋白质组的动态影响对抗癌治疗具有重要意义

Fierro-Monti Ivo, Echeverria Pablo, Racle Julien, Hernandez Celine, Picard Didier, Quadroni Manfredo