Pichinuk相关文献与解析，生知库 | 链接生命科学的每一步

Oral administration of Ketamir-2, a novel ketamine analog, attenuates neuropathic pain in rodent models via selective NMDA antagonism

口服新型氯胺酮类似物Ketamir-2可通过选择性NMDA拮抗作用减轻啮齿动物模型中的神经性疼痛。

期刊:Frontiers in Pharmacology

影响因子:4.8

doi:10.3389/fphar.2025.1650926

Angel, Itzchak; Perelroizen, Rita; Pichinuk, Eddy; Aminov, Erez

发表日期：2025

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Using chanarin-dorfman syndrome patient fibroblasts to explore disease mechanisms and new treatment avenues.

利用chanarin-dorfman综合征患者的成纤维细胞探索疾病机制和新的治疗途径

期刊:Orphanet Journal of Rare Diseases

影响因子:3.5

doi:10.1186/s13023-025-03711-6

Angel Mor, Kleinberg Yuval, Newaz Tanmoy, Li Victoria, Zaid Rinat, Oved Keren, Dorot Orly, Pichinuk Edward, Avitan-Hersh Emily, Saada Ann, Weiss Karin, Zaremberg Vanina, Tal Galit, Zalckvar Einat

细胞生物学

发表日期：2025

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Kynurenic acid, a key L-tryptophan-derived metabolite, protects the heart from an ischemic damage

犬尿酸是L-色氨酸的关键代谢产物，能够保护心脏免受缺血性损伤。

期刊:PLoS One

影响因子:2.6

doi:10.1371/journal.pone.0275550

Bigelman, Einat; Pasmanik-Chor, Metsada; Dassa, Bareket; Itkin, Maxim; Malitsky, Sergey; Dorot, Orly; Pichinuk, Edward; Kleinberg, Yuval; Keren, Gad; Entin-Meer, Michal

代谢

发表日期：2023

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Continuous Inflammatory Stimulation Leads via Metabolic Plasticity to a Prometastatic Phenotype in Triple-Negative Breast Cancer Cells

持续的炎症刺激通过代谢可塑性导致三阴性乳腺癌细胞产生促转移表型

期刊:Cells

影响因子:5.1

doi:10.3390/cells10061356

Dina Morein ，Linor Rubinstein-Achiasaf ，Hadar Brayer ，Orly Dorot ，Edward Pichinuk ，Hagar Ben-Yaakov ，Tsipi Meshel ，Metsada Pasmanik-Chor ，Adit Ben-Baruch

Persistent Inflammatory Stimulation Drives the Conversion of MSCs to Inflammatory CAFs That Promote Pro-Metastatic Characteristics in Breast Cancer Cells

持续的炎症刺激促使 MSCs 转化为炎症 CAF，从而促进乳腺癌细胞的促转移特性

期刊:Cancers

影响因子:

doi:10.3390/cancers13061472

Linor Rubinstein-Achiasaf, Dina Morein, Hagar Ben-Yaakov, Yulia Liubomirski, Tsipi Meshel, Eti Elbaz, Orly Dorot, Edward Pichinuk, Michael Gershovits, Miguel Weil, Adit Ben-Baruch

Purpurin modulates Tau-derived VQIVYK fibrillization and ameliorates Alzheimer's disease-like symptoms in animal model

红紫素调节 Tau 衍生的 VQIVYK 纤维化并改善动物模型中的阿尔茨海默病样症状

期刊:Cellular and Molecular Life Sciences

影响因子:6.2

doi:10.1007/s00018-019-03312-0

Guru Krishnakumar Viswanathan, Dana Shwartz, Yelena Losev, Elad Arad, Chen Shemesh, Edward Pichinuk, Hamutal Engel, Avi Raveh, Raz Jelinek, Itzik Cooper, Fabien Gosselet, Ehud Gazit, Daniel Segal

In vivo anti-MUC1(+) tumor activity and sequences of high-affinity anti-MUC1-SEA antibodies

体内抗MUC1(+)肿瘤活性及高亲和力抗MUC1-SEA抗体的序列

期刊:Cancer Immunology Immunotherapy

影响因子:5.1

doi:10.1007/s00262-020-02547-2

Pichinuk, Edward; Chalik, Michael; Benhar, Itai; Ginat-Koton, Ravit; Ziv, Ravit; Smorodinsky, Nechama I; Haran, Gabi; Garbar, Christian; Bensussan, Armand; Meeker, Alan; Guillaume, Thierry; Rubinstein, Daniel B; Wreschner, Daniel H

Fibril formation and therapeutic targeting of amyloid-like structures in a yeast model of adenine accumulation

腺嘌呤积累的酵母模型中的纤维形成和淀粉样结构的治疗靶向

期刊:Nature Communications

影响因子:14.7

doi:10.1038/s41467-018-07966-5

Dana Laor, Dorin Sade, Shira Shaham-Niv, Dor Zaguri, Myra Gartner, Vasantha Basavalingappa, Avi Raveh, Edward Pichinuk, Hamutal Engel, Keita Iwasaki, Tatsuyuki Yamamoto, Hemanth Noothalapati, Ehud Gazit

Targeting cell-bound MUC1 on myelomonocytic, monocytic leukemias and phenotypically defined leukemic stem cells with anti-SEA module antibodies

利用抗 SEA 模块抗体靶向髓单核细胞白血病、单核细胞白血病和表型明确的白血病干细胞上的细胞结合 MUC1

期刊:Experimental Hematology

影响因子:2.5

doi:10.1016/j.exphem.2018.12.002

Thierry Guillaume, Virginie Dehame, Patrice Chevallier, Pierre Peterlin, Alice Garnier, Marc Grégoire, Edward Pichinuk, Daniel B Rubinstein, Daniel H Wreschner

KETAMIR-2, a new molecular entity and novel ketamine analog

KETAMIR-2 是一种新型分子实体和新型氯胺酮类似物

Oral administration of Ketamir-2, a novel ketamine analog, attenuates neuropathic pain in rodent models via selective NMDA antagonism

口服新型氯胺酮类似物Ketamir-2可通过选择性NMDA拮抗作用减轻啮齿动物模型中的神经性疼痛。

Using chanarin-dorfman syndrome patient fibroblasts to explore disease mechanisms and new treatment avenues.

利用chanarin-dorfman综合征患者的成纤维细胞探索疾病机制和新的治疗途径

Kynurenic acid, a key L-tryptophan-derived metabolite, protects the heart from an ischemic damage

犬尿酸是L-色氨酸的关键代谢产物，能够保护心脏免受缺血性损伤。

Continuous Inflammatory Stimulation Leads via Metabolic Plasticity to a Prometastatic Phenotype in Triple-Negative Breast Cancer Cells

持续的炎症刺激通过代谢可塑性导致三阴性乳腺癌细胞产生促转移表型

Persistent Inflammatory Stimulation Drives the Conversion of MSCs to Inflammatory CAFs That Promote Pro-Metastatic Characteristics in Breast Cancer Cells

持续的炎症刺激促使 MSCs 转化为炎症 CAF，从而促进乳腺癌细胞的促转移特性

Purpurin modulates Tau-derived VQIVYK fibrillization and ameliorates Alzheimer's disease-like symptoms in animal model

红紫素调节 Tau 衍生的 VQIVYK 纤维化并改善动物模型中的阿尔茨海默病样症状

In vivo anti-MUC1(+) tumor activity and sequences of high-affinity anti-MUC1-SEA antibodies

体内抗MUC1(+)肿瘤活性及高亲和力抗MUC1-SEA抗体的序列

Fibril formation and therapeutic targeting of amyloid-like structures in a yeast model of adenine accumulation

腺嘌呤积累的酵母模型中的纤维形成和淀粉样结构的治疗靶向

Targeting cell-bound MUC1 on myelomonocytic, monocytic leukemias and phenotypically defined leukemic stem cells with anti-SEA module antibodies

利用抗 SEA 模块抗体靶向髓单核细胞白血病、单核细胞白血病和表型明确的白血病干细胞上的细胞结合 MUC1