日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Deletion of Exon 51 in a Humanized Duchenne Muscular Dystrophy Mouse Model Abolishes Ventricular Arrhythmia Predisposition

在人源化杜氏肌营养不良症小鼠模型中,删除第51号外显子可消除室性心律失常易感性

Perelli, Robin M; Sitton, Madeleine J; Bohning, Joel D; Pickar-Oliver, Adrian; McCullough, K Tyler; Moya-Mendez, Mary E; Zheng, Scott; Daniels, Heather; Devlin, Garth; Asokan, Aravind; Gersbach, Charles A; Landstrom, Andrew P

Engineered Cas9 variants bypass Keap1-mediated degradation in human cells and enhance epigenome editing efficiency

经过基因工程改造的Cas9变体可绕过Keap1介导的降解,从而提高人类细胞中的表观基因组编辑效率。

Jianfeng Chen ,Siyuan Su ,Adrian Pickar-Oliver ,Anna M Chiarella ,Quentin Hahn ,Dennis Goldfarb ,Erica W Cloer ,George W Small ,Smaran Sivashankar ,Dale A Ramsden ,Michael B Major ,Nathaniel A Hathaway ,Charles A Gersbach ,Pengda Liu

Branched-chain α-ketoacids are preferentially reaminated and activate protein synthesis in the heart

支链 α-酮酸优先被重新胺化并激活心脏中的蛋白质合成

Jacquelyn M Walejko #, Bridgette A Christopher #, Scott B Crown #, Guo-Fang Zhang, Adrian Pickar-Oliver, Takeshi Yoneshiro, Matthew W Foster, Stephani Page, Stephan van Vliet, Olga Ilkayeva, Michael J Muehlbauer, Matthew W Carson, Joseph T Brozinick, Craig D Hammond, Ruth E Gimeno, M Arthur Moseley,

Full-length dystrophin restoration via targeted exon integration by AAV-CRISPR in a humanized mouse model of Duchenne muscular dystrophy

在杜氏肌营养不良症人源化小鼠模型中,通过 AAV-CRISPR 靶向外显子整合实现全长肌营养不良蛋白修复

Adrian Pickar-Oliver, Veronica Gough, Joel D Bohning, Siyan Liu, Jacqueline N Robinson-Hamm, Heather Daniels, William H Majoros, Garth Devlin, Aravind Asokan, Charles A Gersbach

Redirecting Vesicular Transport to Improve Nonviral Delivery of Molecular Cargo

重定向囊泡运输以改善分子货物的非病毒运送

Mao Mao, Chun-Chi Chang, Adrian Pickar-Oliver, Lisa D Cervia, Liangli Wang, Jing Ji, Paloma B Liton, Charles A Gersbach, Fan Yuan

The next generation of CRISPR-Cas technologies and applications

下一代 CRISPR-Cas 技术及应用

Pickar-Oliver, Adrian; Gersbach, Charles A

Targeted transcriptional modulation with type I CRISPR-Cas systems in human cells

使用 I 型 CRISPR-Cas 系统在人类细胞中进行靶向转录调控

Adrian Pickar-Oliver, Joshua B Black, Mae M Lewis, Kevin J Mutchnick, Tyler S Klann, Kylie A Gilcrest, Madeleine J Sitton, Christopher E Nelson, Alejandro Barrera, Luke C Bartelt, Timothy E Reddy, Chase L Beisel, Rodolphe Barrangou, Charles A Gersbach

Estradiol and progesterone bioavailability for moderate to severe vasomotor symptom treatment and endometrial protection with the continuous-combined regimen of TX-001HR (oral estradiol and progesterone capsules)

TX-001HR(口服雌二醇和孕酮胶囊)连续联合疗法对中度至重度血管舒缩症状治疗和子宫内膜保护的雌二醇和孕酮生物利用度

Lobo, Rogerio A; Liu, James; Stanczyk, Frank Z; Constantine, Ginger D; Pickar, James H; Shadiack, Annette M; Bernick, Brian; Mirkin, Sebastian

The Surprise Question and Identification of Palliative Care Needs among Hospitalized Patients with Advanced Hematologic or Solid Malignancies

住院晚期血液系统或实体恶性肿瘤患者的姑息治疗需求识别及意外问题

Hudson, Kathryn Elizabeth; Wolf, Steven Paul; Samsa, Gregory P; Kamal, Arif H; Abernethy, Amy Pickar; LeBlanc, Thomas William

Neural Responses to Physical Characteristics of a High-velocity, Low-amplitude Spinal Manipulation: Effect of Thrust Direction

高速低振幅脊柱推拿的物理特性引起的神经反应:推力方向的影响

Reed, William R; Long, Cynthia R; Kawchuk, Gregory N; Sozio, Randall S; Pickar, Joel G