日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Targeting the Ubiquinol-Reduction (Q(i)) Site of the Mitochondrial Cytochrome bc(1) Complex for the Development of Next Generation Quinolone Antimalarials

靶向线粒体细胞色素bc(1)复合物的泛醌还原(Q(i))位点以开发下一代喹诺酮类抗疟药

Amporndanai, Kangsa; Pinthong, Nattapon; O'Neill, Paul M; Hong, W David; Amewu, Richard K; Pidathala, Chandrakala; Berry, Neil G; Leung, Suet C; Ward, Stephen A; Biagini, Giancarlo A; Hasnain, S Samar; Antonyuk, Svetlana V

A tetraoxane-based antimalarial drug candidate that overcomes PfK13-C580Y dependent artemisinin resistance

一种基于四氧烷基的抗疟疾候选药物,可克服 PfK13-C580Y 依赖的青蒿素耐药性。

O'Neill, Paul M; Amewu, Richard K; Charman, Susan A; Sabbani, Sunil; Gnädig, Nina F; Straimer, Judith; Fidock, David A; Shore, Emma R; Roberts, Natalie L; Wong, Michael H-L; Hong, W David; Pidathala, Chandrakala; Riley, Chris; Murphy, Ben; Aljayyoussi, Ghaith; Gamo, Francisco Javier; Sanz, Laura; Rodrigues, Janneth; Cortes, Carolina Gonzalez; Herreros, Esperanza; Angulo-Barturén, Iñigo; Jiménez-Díaz, María Belén; Bazaga, Santiago Ferrer; Martínez-Martínez, María Santos; Campo, Brice; Sharma, Raman; Ryan, Eileen; Shackleford, David M; Campbell, Simon; Smith, Dennis A; Wirjanata, Grennady; Noviyanti, Rintis; Price, Ric N; Marfurt, Jutta; Palmer, Michael J; Copple, Ian M; Mercer, Amy E; Ruecker, Andrea; Delves, Michael J; Sinden, Robert E; Siegl, Peter; Davies, Jill; Rochford, Rosemary; Kocken, Clemens H M; Zeeman, Anne-Marie; Nixon, Gemma L; Biagini, Giancarlo A; Ward, Stephen A

Generation of quinolone antimalarials targeting the Plasmodium falciparum mitochondrial respiratory chain for the treatment and prophylaxis of malaria.

开发针对恶性疟原虫线粒体呼吸链的喹诺酮类抗疟药,用于治疗和预防疟疾

Biagini Giancarlo A, Fisher Nicholas, Shone Alison E, Mubaraki Murad A, Srivastava Abhishek, Hill Alisdair, Antoine Thomas, Warman Ashley J, Davies Jill, Pidathala Chandrakala, Amewu Richard K, Leung Suet C, Sharma Raman, Gibbons Peter, Hong David W, Pacorel Bénédicte, Lawrenson Alexandre S, Charoensutthivarakul Sitthivut, Taylor Lee, Berger Olivier, Mbekeani Alison, Stocks Paul A, Nixon Gemma L, Chadwick James, Hemingway Janet, Delves Michael J, Sinden Robert E, Zeeman Anne-Marie, Kocken Clemens H M, Berry Neil G, O'Neill Paul M, Ward Stephen A

Identification, design and biological evaluation of heterocyclic quinolones targeting Plasmodium falciparum type II NADH:quinone oxidoreductase (PfNDH2)

针对恶性疟原虫 II 型 NADH:醌氧化还原酶 (PfNDH2) 的杂环喹诺酮的鉴定、设计和生物学评价

Leung, Suet C; Gibbons, Peter; Amewu, Richard; Nixon, Gemma L; Pidathala, Chandrakala; Hong, W David; Pacorel, Bénédicte; Berry, Neil G; Sharma, Raman; Stocks, Paul A; Srivastava, Abhishek; Shone, Alison E; Charoensutthivarakul, Sitthivut; Taylor, Lee; Berger, Olivier; Mbekeani, Alison; Hill, Alasdair; Fisher, Nicholas E; Warman, Ashley J; Biagini, Giancarlo A; Ward, Stephen A; O'Neill, Paul M

Identification of novel antimalarial chemotypes via chemoinformatic compound selection methods for a high-throughput screening program against the novel malarial target, PfNDH2: increasing hit rate via virtual screening methods.

通过化学信息学化合物选择方法鉴定新型抗疟疾化学类型,用于针对新型疟疾靶点 PfNDH2 的高通量筛选程序:通过虚拟筛选方法提高命中率

Sharma Raman, Lawrenson Alexandre S, Fisher Nicholas E, Warman Ashley J, Shone Alison E, Hill Alasdair, Mbekeani Alison, Pidathala Chandrakala, Amewu Richard K, Leung Suet, Gibbons Peter, Hong David W, Stocks Paul, Nixon Gemma L, Chadwick James, Shearer Joanne, Gowers Ian, Cronk David, Parel Serge P, O'Neill Paul M, Ward Stephen A, Biagini Giancarlo A, Berry Neil G