日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

TORC1-dependent sorting of PI(3,5)P(2) is required for vacuole membrane remodeling and signaling endosome formation

TORC1依赖的PI(3,5)P(2)分选是液泡膜重塑和信号内体形成所必需的。

期刊:Molecular Biology of the Cell
影响因子:2.7
doi:10.1091/mbc.E25-10-0498
Brinks, Frederik; Arens, Annabel; Kurre, Rainer; Piehler, Jacob; Langemeyer, Lars; Ungermann, Christian
信号转导
ORC1
发表日期：2026
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Live-cell magnetic manipulation of recycling endosomes reveals their direct effect on actin protrusions to promote invasive migration.

活细胞磁性操控回收内体揭示了其对肌动蛋白突起的直接影响，从而促进侵袭性迁移

期刊:Science Advances
影响因子:12.5
doi:10.1126/sciadv.adu6361
Gemperle Jakub, Liße Domenik, Kappen Marie, Secret Emilie, Coppey Mathieu, Gregor Martin, Menager Christine, Piehler Jacob, Caswell Patrick
细胞生物学
发表日期：2025
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Structure of the interleukin-5 receptor complex exemplifies the organizing principle of common beta cytokine signaling.

白细胞介素-5受体复合物的结构体现了β细胞因子信号传导的组织原则

期刊:Molecular Cell
影响因子:16.6
doi:10.1016/j.molcel.2024.03.023
Caveney Nathanael A, Rodriguez Grayson E, Pollmann Christoph, Meyer Thomas, Borowska Marta T, Wilson Steven C, Wang Nan, Xiang Xinyu, Householder Karsten D, Tao Pingdong, Su Leon L, Saxton Robert A, Piehler Jacob, Garcia K Christopher
细胞生物学
发表日期：2024
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Correlative single-molecule and structured illumination microscopy of fast dynamics at the plasma membrane

利用关联单分子显微镜和结构光照明显微镜研究质膜上的快速动力学

期刊:Nature Communications
影响因子:15.7
doi:10.1038/s41467-024-49876-9
Winkelmann, Hauke; Richter, Christian P; Eising, Jasper; Piehler, Jacob; Kurre, Rainer
发表日期：2024
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Next-Generation JAK2 Inhibitors for the Treatment of Myeloproliferative Neoplasms: Lessons from Structure-Based Drug Discovery Approaches

用于治疗骨髓增生性肿瘤的新一代JAK2抑制剂：基于结构的药物发现方法带来的启示

期刊:Blood Cancer Discovery
影响因子:11.5
doi:10.1158/2643-3230.BCD-22-0189
Nair, Pramod C; Piehler, Jacob; Tvorogov, Denis; Ross, David M; Lopez, Angel F; Gotlib, Jason; Thomas, Daniel
JAK/STAT
肿瘤
肿瘤免疫
JAK2
发表日期：2023
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The HOPS tethering complex is required to maintain signaling endosome identity and TORC1 activity

HOPS 连接复合物对于维持信号内体特性和 TORC1 活性是必需的。

期刊:Journal of Cell Biology
影响因子:6.4
doi:10.1083/jcb.202109084
Gao, Jieqiong; Nicastro, Raffaele; Péli-Gulli, Marie-Pierre; Grziwa, Sophie; Chen, Zilei; Kurre, Rainer; Piehler, Jacob; De Virgilio, Claudio; Fröhlich, Florian; Ungermann, Christian
信号转导
HOP
ORC1
发表日期：2022
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Engineering an anti-HER2 biparatopic antibody with a multimodal mechanism of action.

构建具有多模式作用机制的抗 HER2 双位点抗体

期刊:Nature Communications
影响因子:15.7
doi:10.1038/s41467-021-23948-6
Kast Florian, Schwill Martin, Stüber Jakob C, Pfundstein Svende, Nagy-Davidescu Gabriela, Rodríguez Josep M Monné, Seehusen Frauke, Richter Christian P, Honegger Annemarie, Hartmann Karen Patricia, Weber Thomas G, Kroener Felix, Ernst Patrick, Piehler Jacob, Plückthun Andreas
免疫/内分泌
发表日期：2021
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TIN2 is an architectural protein that facilitates TRF2-mediated trans- and cis-interactions on telomeric DNA

TIN2 是一种结构蛋白，可促进端粒 DNA 上 TRF2 介导的反式和顺式相互作用。

期刊:Nucleic Acids Research
影响因子:13.1
doi:10.1093/nar/gkab1142
Kaur, Parminder; Barnes, Ryan; Pan, Hai; Detwiler, Ariana C; Liu, Ming; Mahn, Chelsea; Hall, Jonathan; Messenger, Zach; You, Changjiang; Piehler, Jacob; Smart, Robert C; Riehn, Robert; Opresko, Patricia L; Wang, Hong
发表日期：2021
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Tuning MPL signaling to influence hematopoietic stem cell differentiation and inhibit essential thrombocythemia progenitors

调节MPL信号通路以影响造血干细胞分化并抑制必需血小板增多症祖细胞

期刊:Proceedings of the National Academy of Sciences of the United States of America
影响因子:9.1
doi:10.1073/pnas.2017849118
Cui, Lu; Moraga, Ignacio; Lerbs, Tristan; Van Neste, Camille; Wilmes, Stephan; Tsutsumi, Naotaka; Trotman-Grant, Aaron Claudius; Gakovic, Milica; Andrews, Sarah; Gotlib, Jason; Darmanis, Spyros; Enge, Martin; Quake, Stephen; Hitchcock, Ian S; Piehler, Jacob; Garcia, K Christopher; Wernig, Gerlinde
血小板
发育与干细胞
信号转导
MPL
干细胞
细胞生物学
发表日期：2021
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Mechanism of homodimeric cytokine receptor activation and dysregulation by oncogenic mutations

致癌突变激活同源二聚体细胞因子受体及其失调的机制

期刊:Science
影响因子:45.8
doi:10.1126/science.aaw3242
Wilmes, Stephan; Hafer, Maximillian; Vuorio, Joni; Tucker, Julie A; Winkelmann, Hauke; Löchte, Sara; Stanly, Tess A; Pulgar Prieto, Katiuska D; Poojari, Chetan; Sharma, Vivek; Richter, Christian P; Kurre, Rainer; Hubbard, Stevan R; Garcia, K Christopher; Moraga, Ignacio; Vattulainen, Ilpo; Hitchcock, Ian S; Piehler, Jacob
肿瘤
肿瘤免疫
信号转导
细胞生物学
免疫/内分泌
发表日期：2020
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