Importance of Binding Site Hydration and Flexibility Revealed When Optimizing a Macrocyclic Inhibitor of the Keap1-Nrf2 Protein-Protein Interaction
优化 Keap1-Nrf2 蛋白质-蛋白质相互作用的大环抑制剂时揭示结合位点水合和柔韧性的重要性
期刊:Journal of Medicinal Chemistry
影响因子:6.8
doi:10.1021/acs.jmedchem.1c01975
Fabio Begnini, Stefan Geschwindner, Patrik Johansson, Lisa Wissler, Richard J Lewis, Emma Danelius, Andreas Luttens, Pierre Matricon, Jens Carlsson, Stijn Lenders, Beate König, Anna Friedel, Peter Sjö, Stefan Schiesser, Jan Kihlberg