日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Locus-level L1 DNA methylation profiling reveals the epigenetic and transcriptional interplay between L1s and their integration sites

基因座水平的 L1 DNA 甲基化分析揭示了 L1 与其整合位点之间的表观遗传和转录相互作用

Sophie Lanciano, Claude Philippe, Arpita Sarkar, David Pratella, Cécilia Domrane, Aurélien J Doucet, Dominic van Essen, Simona Saccani, Laure Ferry, Pierre-Antoine Defossez, Gael Cristofari

RSK3 switches cell fate: from stress-induced senescence to malignant progression

RSK3 改变细胞命运:从应激诱导的衰老到恶性进展

Anda Huna, Jean-Michel Flaman #, Catalina Lodillinsky #, Kexin Zhu, Gabriela Makulyte, Victoria Pakulska, Yohann Coute, Clémence Ruisseaux, Pierre Saintigny, Hector Hernandez-Vargas, Pierre-Antoine Defossez, Mathieu Boissan, Nadine Martin, David Bernard

E4F1 and ZNF148 are transcriptional activators of the -57A > C and wild-type TERT promoter

E4F1 和 ZNF148 是 -57A > C 和野生型 TERT 启动子的转录激活因子

Boon Haow Chua, Nurkaiyisah Zaal Anuar, Laure Ferry, Cecilia Domrane, Anna Wittek, Vineeth T Mukundan, Sudhakar Jha, Falk Butter, Daniel G Tenen, Pierre-Antoine Defossez, Dennis Kappei

Unchanged PCNA and DNMT1 dynamics during replication in DNA ligase I-deficient cells but abnormal chromatin levels of non-replicative histone H1

在 DNA 连接酶 I 缺陷细胞中,复制过程中 PCNA 和 DNMT1 动态不变,但非复制组蛋白 H1 的染色质水平异常

Seema Khattri Bhandari, Nathaniel Wiest, Annahita Sallmyr, Ruofei Du, Laure Ferry, Pierre-Antoine Defossez, Alan E Tomkinson

Structural basis for activation of DNMT1

DNMT1 激活的结构基础

Amika Kikuchi #, Hiroki Onoda #, Kosuke Yamaguchi, Satomi Kori, Shun Matsuzawa, Yoshie Chiba, Shota Tanimoto, Sae Yoshimi, Hiroki Sato, Atsushi Yamagata, Mikako Shirouzu, Naruhiko Adachi, Jafar Sharif, Haruhiko Koseki, Atsuya Nishiyama, Makoto Nakanishi, Pierre-Antoine Defossez, Kyohei Arita

Context-dependent CpG methylation directs cell-specific binding of transcription factor ZBTB38

上下文相关的 CpG 甲基化指导转录因子 ZBTB38 的细胞特异性结合

Claire Marchal, Pierre-Antoine Defossez, Benoit Miotto

Genetic screens reveal mechanisms for the transcriptional regulation of tissue-specific genes in normal cells and tumors

基因筛选揭示了正常细胞和肿瘤中组织特异性基因转录调控的机制

Ikrame Naciri ,Marthe Laisné ,Laure Ferry ,Morgane Bourmaud ,Nikhil Gupta ,Selene Di Carlo ,Anda Huna ,Nadine Martin ,Lucie Peduto ,David Bernard ,Olivier Kirsh ,Pierre-Antoine Defossez

Structure of the UHRF1 Tandem Tudor Domain Bound to a Methylated Non-histone Protein, LIG1, Reveals Rules for Binding and Regulation

与甲基化非组蛋白 LIG1 结合的 UHRF1 串联 Tudor 结构域的结构揭示了结合和调控规则

Satomi Kori, Laure Ferry, Shohei Matano, Tomohiro Jimenji, Noriyuki Kodera, Takeshi Tsusaka, Rumie Matsumura, Takashi Oda, Mamoru Sato, Naoshi Dohmae, Toshio Ando, Yoichi Shinkai, Pierre-Antoine Defossez, Kyohei Arita

Stabilization of the methyl-CpG binding protein ZBTB38 by the deubiquitinase USP9X limits the occurrence and toxicity of oxidative stress in human cells

去泛素化酶USP9X对甲基-CpG结合蛋白ZBTB38的稳定作用,限制了人类细胞中氧化应激的发生及其毒性。

Benoit Miotto ,Claire Marchal ,Guillaume Adelmant ,Nadège Guinot ,Ping Xie ,Jarrod A Marto ,Lingqiang Zhang ,Pierre-Antoine Defossez

The nuclear receptor RXRA controls cellular senescence by regulating calcium signaling

核受体 RXRA 通过调节钙信号来控制细胞衰老

Xingjie Ma, Marine Warnier, Clotilde Raynard, Mylène Ferrand, Olivier Kirsh, Pierre-Antoine Defossez, Nadine Martin, David Bernard