日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Transgene-induced cardiotoxicity in high-dose AAV gene transfer

高剂量AAV基因转移中转基因诱导的心脏毒性

Biquand, Ariane; Gicquel, Evelyne; Poupiot, Jerome; Faivre, Marine; Campuzano, Stephany; Bourgeton, Tiffany; Le Brun, Pierre-Romain; Veron, Philippe; Brureau, Anthony; Richard, Isabelle

An engineered AAV targeting integrin alpha V beta 6 presents improved myotropism across species

针对整合素 alpha V beta 6 的工程化 AAV 可在各个物种中表现出更好的肌向性

Ai Vu Hong #, Laurence Suel #, Eva Petat, Auriane Dubois, Pierre-Romain Le Brun, Nicolas Guerchet, Philippe Veron, Jérôme Poupiot, Isabelle Richard

Mesenchymal stromal cell-derived extracellular vesicles therapy openings new translational challenges in immunomodulating acute liver inflammation

间充质干细胞来源的细胞外囊泡疗法为免疫调节急性肝脏炎症带来了新的转化挑战

Sitbon, Alexandre; Delmotte, Pierre-Romain; Pistorio, Valéria; Halter, Sébastien; Gallet, Jérémy; Gautheron, Jérémie; Monsel, Antoine

Synergism of dual AAV gene therapy and rapamycin rescues GSDIII phenotype in muscle and liver

双重AAV基因疗法与雷帕霉素的协同作用可挽救肌肉和肝脏中的GSDIII表型

Louisa Jauze ,Mallaury Vie ,Quentin Miagoux ,Lucille Rossiaud ,Patrice Vidal ,Valle Montalvo-Romeral ,Hanadi Saliba ,Margot Jarrige ,Helene Polveche ,Justine Nozi ,Pierre-Romain Le Brun ,Luca Bocchialini ,Amandine Francois ,Jérémie Cosette ,Jérémy Rouillon ,Fanny Collaud ,Fanny Bordier ,Emilie Bertil-Froidevaux ,Christophe Georger ,Laetitia van Wittenberghe ,Adeline Miranda ,Nathalie F Daniele ,David-Alexandre Gross ,Lucile Hoch ,Xavier Nissan ,Giuseppe Ronzitti

Repeated dosing of AAV-mediated liver gene therapy in juvenile rat and mouse models of Crigler-Najjar syndrome type I.

在克里格勒-纳贾尔综合征 I 型幼年大鼠和小鼠模型中重复进行 AAV 介导的肝脏基因治疗

Shi Xiaoxia, Bortolussi Giulia, Collaud Fanny, Le Brun Pierre-Romain, Bloemendaal Lysbeth Ten, Guerchet Nicolas, Rudi de Waart Dirk, Sellier Pauline, Duijst Suzanne, Veron Philippe, Mingozzi Federico, Kishimoto Takashi Kei, Ronzitti Giuseppe, Bosma Piter, Muro Andrés F

Efficacy, pharmacokinetics, and safety in the mouse and primate retina of dual AAV vectors for Usher syndrome type 1B

双 AAV 载体对 1B 型 Usher 综合征的小鼠和灵长类视网膜的疗效、药代动力学和安全性

Rita Ferla, Fabio Dell'Aquila, Monica Doria, Maria Ferraiuolo, Alessia Noto, Fabiana Grazioli, Virginia Ammendola, Francesco Testa, Paolo Melillo, Carolina Iodice, Giulia Risca, Novella Tedesco, Pierre Romain le Brun, Enrico Maria Surace, Francesca Simonelli, Stefania Galimberti, Maria Grazia Valsec

Ultrasound and Transcriptomics Identify a Differential Impact of Cisplatin and Histone Deacetylation on Tumor Structure and Microenvironment in a Patient-Derived In Vivo Model of Gastric Cancer

超声和转录组学分析揭示顺铂和组蛋白去乙酰化对胃癌患者来源体内模型肿瘤结构和微环境的不同影响

Venkatasamy, Aina; Guerin, Eric; Blanchet, Anais; Orvain, Christophe; Devignot, Véronique; Jung, Matthieu; Jung, Alain C; Chenard, Marie-Pierre; Romain, Benoit; Gaiddon, Christian; Mellitzer, Georg