Allosteric SHP2 Inhibitor, IACS-13909, Overcomes EGFR-Dependent and EGFR-Independent Resistance Mechanisms toward Osimertinib
变构SHP2抑制剂IACS-13909可克服EGFR依赖性和EGFR非依赖性奥希替尼耐药机制
期刊:Cancer Research
影响因子:16.6
doi:10.1158/0008-5472.CAN-20-1634
Sun, Yuting; Meyers, Brooke A; Czako, Barbara; Leonard, Paul; Mseeh, Faika; Harris, Angela L; Wu, Qi; Johnson, Sarah; Parker, Connor A; Cross, Jason B; Di Francesco, Maria Emilia; Bivona, Benjamin J; Bristow, Christopher A; Burke, Jason P; Carrillo, Caroline C; Carroll, Christopher L; Chang, Qing; Feng, Ningping; Gao, Guang; Gera, Sonal; Giuliani, Virginia; Huang, Justin K; Jiang, Yongying; Kang, Zhijun; Kovacs, Jeffrey J; Liu, Chiu-Yi; Lopez, Anastasia M; Ma, Xiaoyan; Mandal, Pijus K; McAfoos, Timothy; Miller, Meredith A; Mullinax, Robert A; Peoples, Michael; Ramamoorthy, Vandhana; Seth, Sahil; Spencer, Nakia D; Suzuki, Erika; Williams, Christopher C; Yu, Simon S; Zuniga, Andy M; Draetta, Giulio F; Marszalek, Joseph R; Heffernan, Timothy P; Kohl, Nancy E; Jones, Philip