日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Capturing macromolecular dynamics using time-resolved serial crystallography at X- ray free electron lasers and synchrotron light sources

利用X射线自由电子激光器和同步辐射光源,通过时间分辨串行晶体学技术捕捉大分子动力学

Nitzsche, Richard; Zagoriy, Vyacheslav; Lucius, Richard; Gupta, Nishith; Mous, Sandra; Gotthard, Guillaume; Ehrenberg, David; Sen, Saumik; Weinert, Tobias; Johnson, Philip; James, Daniel; Nass, Karol; Furrer, Antonia; Ma, Pikyee; Bruenle, Steffen; Casadei, Cecilia; Martiel, Isabelle; Dworkowski, Florian; Gashi, Dardan; Skopintsev, Petr; Wranik, Maximilian; Knopp, Gregor; Panepucci, Ezequiel; Panneels, Valerie; Cirelli, Claudio; Ozerov, Dmitry; Schertler, Gebhard; Wang, Meitian; Milne, Chris; Standfuss, Joerg; Schapiro, Igor; Heberle, Joachim; Nogly, Przemyslaw

High-mass MALDI-MS unravels ligand-mediated G protein-coupling selectivity to GPCRs

高通量MALDI-MS揭示配体介导的G蛋白偶联对GPCR的选择性

Wu, Na; Olechwier, Agnieszka M; Brunner, Cyrill; Edwards, Patricia C; Tsai, Ching-Ju; Tate, Christopher G; Schertler, Gebhard F X; Schneider, Gisbert; Deupi, Xavier; Zenobi, Renato; Ma, Pikyee

Membrane Sensor Histidine Kinases: Insights from Structural, Ligand and Inhibitor Studies of Full-Length Proteins and Signalling Domains for Antibiotic Discovery

膜传感器组氨酸激酶:从全长蛋白和信号结构域的结构、配体和抑制剂研究中获得的抗生素发现启示

Ma, Pikyee; Phillips-Jones, Mary K

The gelatinase biosynthesis-activating pheromone binds and stabilises the FsrB membrane protein in Enterococcus faecalis quorum sensing

明胶酶生物合成激活信息素结合并稳定粪肠球菌群体感应中的FsrB膜蛋白。

Littlewood, Sean; Tattersall, Helena; Hughes, Charlotte S; Hussain, Rohanah; Ma, Pikyee; Harding, Stephen E; Nakayama, Jiro; Phillips-Jones, Mary K

Crystal structure of rhodopsin in complex with a mini-G(o) sheds light on the principles of G protein selectivity

视紫红质与迷你G(o)复合物的晶体结构揭示了G蛋白选择性的原理

Tsai, Ching-Ju; Pamula, Filip; Nehmé, Rony; Mühle, Jonas; Weinert, Tobias; Flock, Tilman; Nogly, Przemyslaw; Edwards, Patricia C; Carpenter, Byron; Gruhl, Thomas; Ma, Pikyee; Deupi, Xavier; Standfuss, Jörg; Tate, Christopher G; Schertler, Gebhard F X

Production of membrane proteins for characterisation of their pheromone-sensing and antimicrobial resistance functions

生产膜蛋白以表征其信息素感知和抗菌素耐药功能

Azam, Aalishaa A; Kinder, Jean M; Khan, G Nasir; Alase, Ade; Ma, Pikyee; Liu, Yang; Ault, James R; Henderson, Peter J F; Chowdhry, Babur Z; Alexander, Bruce D; Harding, Stephen E; Phillips-Jones, Mary K

Purification of bacterial membrane sensor kinases and biophysical methods for determination of their ligand and inhibitor interactions

细菌膜传感器激酶的纯化及其配体和抑制剂相互作用的生物物理测定方法

Hussain, Rohanah; Harding, Stephen E; Hughes, Charlotte S; Ma, Pikyee; Patching, Simon G; Edara, Shalini; Siligardi, Giuliano; Henderson, Peter J F; Phillips-Jones, Mary K

In meso in situ serial X-ray crystallography of soluble and membrane proteins at cryogenic temperatures.

在低温下对可溶性和膜蛋白进行内消旋原位连续X射线晶体学研究

Huang Chia Ying, Olieric Vincent, Ma Pikyee, Howe Nicole, Vogeley Lutz, Liu Xiangyu, Warshamanage Rangana, Weinert Tobias, Panepucci Ezequiel, Kobilka Brian, Diederichs Kay, Wang Meitian, Caffrey Martin

Allantoin transport protein, PucI, from Bacillus subtilis: evolutionary relationships, amplified expression, activity and specificity

枯草芽孢杆菌尿囊素转运蛋白 PucI:进化关系、扩增表达、活性和特异性

Ma, Pikyee; Patching, Simon G; Ivanova, Ekaterina; Baldwin, Jocelyn M; Sharples, David; Baldwin, Stephen A; Henderson, Peter J F

An efficient strategy for small-scale screening and production of archaeal membrane transport proteins in Escherichia coli

大肠杆菌中古细菌膜转运蛋白小规模筛选和生产的有效策略

Pikyee Ma, Filipa Varela, Malgorzata Magoch, Ana Rita Silva, Ana Lúcia Rosário, José Brito, Tânia Filipa Oliveira, Przemyslaw Nogly, Miguel Pessanha, Meike Stelter, Arnulf Kletzin, Peter J F Henderson, Margarida Archer