日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Novel hematopoietic progenitor kinase 1 inhibitor KHK-6 enhances T-cell activation

新型造血祖细胞激酶 1 抑制剂 KHK-6 可增强 T 细胞活化

Min Jeong Ahn, Eun Hye Kim, Yunha Choi, Chong Hak Chae, Pilho Kim, Seong Hwan Kim

Orally bioavailable BTK PROTAC active against wild-type and C481 mutant BTKs in human lymphoma CDX mouse models

口服生物可利用的 BTK PROTAC 对人类淋巴瘤 CDX 小鼠模型中的野生型和 C481 突变型 BTK 具有活性

Ye Seul Lim, Sun-Mi Yoo, Vineet Patil, Han Wool Kim, Hyun-Hwi Kim, Beomseon Suh, Ji Youn Park, Na-Rae Jeong, Chi Hoon Park, Je Ho Ryu, Byung-Hoon Lee, Pilho Kim, Song Hee Lee

DCLK1 promotes colorectal cancer stemness and aggressiveness via the XRCC5/COX2 axis

DCLK1通过XRCC5/COX2轴促进结直肠癌干细胞特性和侵袭性。

Kim, Jee-Heun; Park, So-Yeon; Jeon, So-El; Choi, Jang-Hyun; Lee, Choong-Jae; Jang, Tae-Young; Yun, Hyeon-Ji; Lee, Yuno; Kim, Pilho; Cho, Sang Hee; Lee, Ji Shin; Nam, Jeong-Seok

Synthesis and anti-influenza virus activity of 4-oxo- or thioxo-4,5-dihydrofuro[3,4-c]pyridin-3(1H)-ones.

4-氧代-或硫代-4,5-二氢呋喃并[3,4-c]吡啶-3(1H)-酮的合成及其抗流感病毒活性

Jang Ye Jin, Achary Raghavendra, Lee Hye Won, Lee Hyo Jin, Lee Chong-Kyo, Han Soo Bong, Jung Young-Sik, Kang Nam Sook, Kim Pilho, Kim Meehyein

3D-QSAR and cell wall permeability of antitubercular nitroimidazoles against Mycobacterium tuberculosis

抗结核硝基咪唑类药物对结核分枝杆菌的3D-QSAR和细胞壁渗透性

Lee, Sang-Ho; Choi, Minsung; Kim, Pilho; Myung, Pyung Keun

Structure-activity relationships of antitubercular nitroimidazoles. 1. Structural features associated with aerobic and anaerobic activities of 4- and 5-nitroimidazoles

抗结核硝基咪唑的结构-活性关系。1. 4-和 5-硝基咪唑的有氧和无氧活性相关的结构特征

Pilho Kim, Liang Zhang, Ujjini H Manjunatha, Ramandeep Singh, Sejal Patel, Jan Jiricek, Thomas H Keller, Helena I Boshoff, Clifton E Barry 3rd, Cynthia S Dowd

Structure-activity relationships of antitubercular nitroimidazoles. 2. Determinants of aerobic activity and quantitative structure-activity relationships

抗结核硝基咪唑类药物的构效关系。2. 需氧活性的决定因素和定量构效关系

Pilho Kim, Sunhee Kang, Helena I Boshoff, Jan Jiricek, Margaret Collins, Ramandeep Singh, Ujjini H Manjunatha, Pornwaratt Niyomrattanakit, Liang Zhang, Michael Goodwin, Thomas Dick, Thomas H Keller, Cynthia S Dowd, Clifton E Barry 3rd

PA-824 kills nonreplicating Mycobacterium tuberculosis by intracellular NO release

PA-824 通过释放细胞内 NO 杀死非复制型结核分枝杆菌。

Singh, Ramandeep; Manjunatha, Ujjini; Boshoff, Helena I M; Ha, Young Hwan; Niyomrattanakit, Pornwaratt; Ledwidge, Richard; Dowd, Cynthia S; Lee, Ill Young; Kim, Pilho; Zhang, Liang; Kang, Sunhee; Keller, Thomas H; Jiricek, Jan; Barry, Clifton E 3rd

Structure-activity relationships at the 5-position of thiolactomycin: an intact (5R)-isoprene unit is required for activity against the condensing enzymes from Mycobacterium tuberculosis and Escherichia coli

硫乳霉素 5 位结构-活性关系:完整的 (5R)-异戊二烯单元是抵抗结核分枝杆菌和大肠杆菌缩合酶的活性所必需的

Pilho Kim, Yong-Mei Zhang, Gautham Shenoy, Quynh-Anh Nguyen, Helena I Boshoff, Ujjini H Manjunatha, Michael B Goodwin, John Lonsdale, Allen C Price, Darcie J Miller, Ken Duncan, Stephen W White, Charles O Rock, Clifton E Barry 3rd, Cynthia S Dowd

Novel route to 5-position vinyl derivatives of thiolactomycin: Olefination vs. deformylation

硫代乳糖霉素5位乙烯基衍生物的新合成路线:烯烃化与去甲酰化

Kim, Pilho; Barry, Clifton E; Dowd, Cynthia S