Structure-activity relationships at the 5-position of thiolactomycin: an intact (5R)-isoprene unit is required for activity against the condensing enzymes from Mycobacterium tuberculosis and Escherichia coli
硫乳霉素 5 位结构-活性关系:完整的 (5R)-异戊二烯单元是抵抗结核分枝杆菌和大肠杆菌缩合酶的活性所必需的
期刊:Journal of Medicinal Chemistry
影响因子:6.8
doi:10.1021/jm050825p
Pilho Kim, Yong-Mei Zhang, Gautham Shenoy, Quynh-Anh Nguyen, Helena I Boshoff, Ujjini H Manjunatha, Michael B Goodwin, John Lonsdale, Allen C Price, Darcie J Miller, Ken Duncan, Stephen W White, Charles O Rock, Clifton E Barry 3rd, Cynthia S Dowd