日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Menin inhibitor MI-3454 induces remission in MLL1-rearranged and NPM1-mutated models of leukemia

Menin抑制剂MI-3454可诱导MLL1重排和NPM1突变型白血病模型缓解

Szymon Klossowski ,Hongzhi Miao ,Katarzyna Kempinska ,Tao Wu ,Trupta Purohit ,EunGi Kim ,Brian M Linhares ,Dong Chen ,Gloria Jih ,Eric Perkey ,Huang Huang ,Miao He ,Bo Wen ,Yi Wang ,Ke Yu ,Stanley Chun-Wei Lee ,Gwenn Danet-Desnoyers ,Winifred Trotman ,Malathi Kandarpa ,Anitria Cotton ,Omar Abdel-Wahab ,Hongwei Lei ,Yali Dou ,Monica Guzman ,Luke Peterson ,Tanja Gruber ,Sarah Choi ,Duxin Sun ,Pingda Ren ,Lian-Sheng Li ,Yi Liu ,Francis Burrows ,Ivan Maillard ,Tomasz Cierpicki ,Jolanta Grembecka

Selective inhibition of phosphoinositide 3-kinase p110α preserves lymphocyte function

选择性抑制磷酸肌醇 3-激酶 p110α 可保留淋巴细胞功能

Lomon So, Sung Su Yea, Jean S Oak, Mengrou Lu, Arun Manmadhan, Qiao Han Ke, Matthew R Janes, Linda V Kessler, Jeff M Kucharski, Lian-Sheng Li, Michael B Martin, Pingda Ren, Katti A Jessen, Yi Liu, Christian Rommel, David A Fruman

PI3K-δ and PI3K-γ inhibition by IPI-145 abrogates immune responses and suppresses activity in autoimmune and inflammatory disease models

IPI-145 抑制 PI3K-δ 和 PI3K-γ 可消除免疫反应并抑制自身免疫和炎症疾病模型中的活性

David G Winkler, Kerrie L Faia, Jonathan P DiNitto, Janid A Ali, Kerry F White, Erin E Brophy, Melissa M Pink, Jennifer L Proctor, Jennifer Lussier, Christian M Martin, Jennifer G Hoyt, Bonnie Tillotson, Erin L Murphy, Alice R Lim, Brian D Thomas, John R Macdougall, Pingda Ren, Yi Liu, Lian-Sheng Li

The translational landscape of mTOR signalling steers cancer initiation and metastasis

mTOR 信号的转化前景控制癌症的发生和转移

Andrew C Hsieh, Yi Liu, Merritt P Edlind, Nicholas T Ingolia, Matthew R Janes, Annie Sher, Evan Y Shi, Craig R Stumpf, Carly Christensen, Michael J Bonham, Shunyou Wang, Pingda Ren, Michael Martin, Katti Jessen, Morris E Feldman, Jonathan S Weissman, Kevan M Shokat, Christian Rommel, Davide Ruggero

Defining the role of TORC1/2 in multiple myeloma

定义 TORC1/2 在多发性骨髓瘤中的作用

Patricia Maiso, Yi Liu, Brittany Morgan, Abdel Kareem Azab, Pingda Ren, Michel B Martin, Yong Zhang, Yang Liu, Antonio Sacco, Hai Ngo, Feda Azab, Phong Quang, Scott J Rodig, Charles P Lin, Aldo M Roccaro, Christian Rommel, Irene M Ghobrial

Effective and selective targeting of leukemia cells using a TORC1/2 kinase inhibitor

使用 TORC1/2 激酶抑制剂有效且有选择性地靶向白血病细胞

Matthew R Janes, Jose J Limon, Lomon So, Jing Chen, Raymond J Lim, Melissa A Chavez, Collin Vu, Michael B Lilly, Sharmila Mallya, S Tiong Ong, Marina Konopleva, Michael B Martin, Pingda Ren, Yi Liu, Christian Rommel, David A Fruman