日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Early antiretroviral therapy in SIV-infected rhesus macaques reveals a multiphasic, saturable dynamic accumulation of the rebound competent viral reservoir

在感染SIV的恒河猴中,早期抗逆转录病毒疗法揭示了具有反弹能力的病毒库的多相、可饱和的动态积累过程。

Brandon F Keele ,Afam A Okoye ,Christine M Fennessey ,Benjamin Varco-Merth ,Taina T Immonen ,Emek Kose ,Andrew Conchas ,Mykola Pinkevych ,Leslie Lipkey ,Laura Newman ,Agatha Macairan ,Marjorie Bosche ,William J Bosche ,Brian Berkemeier ,Randy Fast ,Mike Hull ,Kelli Oswald ,Rebecca Shoemaker ,Lorna Silipino ,Robert J Gorelick ,Derick Duell ,Alejandra Marenco ,William Brantley ,Jeremy Smedley ,Michael Axthelm ,Miles P Davenport ,Jeffrey D Lifson ,Louis J Picker

CD8+ lymphocytes do not impact SIV reservoir establishment under ART

CD8+淋巴细胞不影响抗逆转录病毒疗法下的SIV病毒库建立。

Maura Statzu # ,Wang Jin # ,Emily J Fray # ,Andrew Kam Ho Wong # ,Mithra R Kumar # ,Elizabeth Ferrer ,Steffen S Docken ,Mykola Pinkevych ,Julia B McBrien ,Christine M Fennessey ,Brandon F Keele ,Shan Liang ,Justin L Harper ,Simona Mutascio ,Lavinia Franchitti ,Hong Wang ,Davide Cicetti ,Steven E Bosinger ,Diane G Carnathan ,Thomas H Vanderford ,David M Margolis ,J Victor Garcia-Martinez ,Ann Chahroudi ,Mirko Paiardini ,Janet Siliciano ,Miles P Davenport ,Deanna A Kulpa ,Robert S Siliciano ,Guido Silvestri

Preferential selection of viral escape mutants by CD8+ T cell 'sieving' of SIV reactivation from latency

CD8+ T细胞通过“筛选”潜伏期SIV病毒的再激活,优先选择病毒逃逸突变体。

Docken, Steffen S; McCormick, Kevin; Pampena, M Betina; Samer, Sadia; Lindemuth, Emily; Pinkevych, Mykola; Viox, Elise G; Wu, Yuhuang; Schlub, Timothy E; Cromer, Deborah; Keele, Brandon F; Paiardini, Mirko; Betts, Michael R; Bar, Katharine J; Davenport, Miles P

Timing of initiation of anti-retroviral therapy predicts post-treatment control of SIV replication

抗逆转录病毒疗法的启动时机可预测治疗后SIV复制的控制情况。

Pinkevych, Mykola; Docken, Steffen S; Okoye, Afam A; Fennessey, Christine M; Del Prete, Gregory Q; Pino, Maria; Harper, Justin L; Betts, Michael R; Paiardini, Mirko; Keele, Brandon F; Davenport, Miles P

CD8+ T cells fail to limit SIV reactivation following ART withdrawal until after viral amplification

CD8+ T 细胞在停止抗逆转录病毒治疗后,直到病毒扩增后才能限制 SIV 的再激活,而此时 CD8+ T 细胞在病毒扩增后才能发挥作用。

Afam A Okoye ,Derick D Duell ,Yoshinori Fukazawa ,Benjamin Varco-Merth ,Alejandra Marenco ,Hannah Behrens ,Morgan Chaunzwa ,Andrea N Selseth ,Roxanne M Gilbride ,Jason Shao ,Paul T Edlefsen ,Romas Geleziunas ,Mykola Pinkevych ,Miles P Davenport ,Kathleen Busman-Sahay ,Michael Nekorchuk ,Haesun Park ,Jeremy Smedley ,Michael K Axthelm ,Jacob D Estes ,Scott G Hansen ,Brandon F Keele ,Jeffery D Lifson ,Louis J Picker

Estimating Initial Viral Levels during Simian Immunodeficiency Virus/Human Immunodeficiency Virus Reactivation from Latency

估算猴免疫缺陷病毒/人类免疫缺陷病毒从潜伏期激活时的初始病毒水平

Pinkevych, Mykola; Fennessey, Christine M; Cromer, Deborah; Tolstrup, Martin; Søgaard, Ole S; Rasmussen, Thomas A; Keele, Brandon F; Davenport, Miles P

Genetically-barcoded SIV facilitates enumeration of rebound variants and estimation of reactivation rates in nonhuman primates following interruption of suppressive antiretroviral therapy

基因条形码标记的SIV有助于统计非人灵长类动物在停止抑制性抗逆转录病毒治疗后出现的病毒反弹变异株,并估计其病毒再激活率。

Fennessey, Christine M; Pinkevych, Mykola; Immonen, Taina T; Reynaldi, Arnold; Venturi, Vanessa; Nadella, Priyanka; Reid, Carolyn; Newman, Laura; Lipkey, Leslie; Oswald, Kelli; Bosche, William J; Trivett, Matthew T; Ohlen, Claes; Ott, David E; Estes, Jacob D; Del Prete, Gregory Q; Lifson, Jeffrey D; Davenport, Miles P; Keele, Brandon F

Modeling of Antilatency Treatment in HIV: What Is the Optimal Duration of Antiretroviral Therapy-Free HIV Remission?

HIV 抗潜伏治疗建模:无抗逆转录病毒疗法 HIV 缓解的最佳持续时间是多久?

Cromer, Deborah; Pinkevych, Mykola; Rasmussen, Thomas A; Lewin, Sharon R; Kent, Stephen J; Davenport, Miles P

Correction: HIV Reactivation from Latency after Treatment Interruption Occurs on Average Every 5-8 Days-Implications for HIV Remission

更正:HIV病毒在治疗中断后平均每5-8天从潜伏状态激活一次——对HIV缓解的影响

Pinkevych, Mykola; Cromer, Deborah; Tolstrup, Martin; Grimm, Andrew J; Cooper, David A; Lewin, Sharon R; Søgaard, Ole S; Rasmussen, Thomas A; Kent, Stephen J; Kelleher, Anthony D; Davenport, Miles P

Modeling of Experimental Data Supports HIV Reactivation from Latency after Treatment Interruption on Average Once Every 5-8 Days

实验数据建模表明,HIV病毒在治疗中断后平均每5-8天会从潜伏状态重新激活一次。

Pinkevych, Mykola; Kent, Stephen J; Tolstrup, Martin; Lewin, Sharon R; Cooper, David A; Søgaard, Ole S; Rasmussen, Thomas A; Kelleher, Anthony D; Cromer, Deborah; Davenport, Miles P