日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Contribution of the Opioid System to the Antidepressant Effects of Fluoxetine

阿片系统对氟西汀抗抑郁作用的贡献

Carazo-Arias, Elena; Nguyen, Phi T; Kass, Marley; Jee, Hyun Jung; Nautiyal, Katherine M; Magalong, Valerie; Coie, Lilian; Andreu, Valentine; Gergues, Mark M; Khalil, Huzefa; Akil, Huda; Arcego, Danusa Mar; Meaney, Michael; Anacker, Christoph; Samuels, Benjamin A; Pintar, John E; Morozova, Irina; Kalachikov, Sergey; Hen, Rene

Site selective C-H functionalization of Mitragyna alkaloids reveals a molecular switch for tuning opioid receptor signaling efficacy

帽柱木碱的位点选择性CH官能化揭示了一种调节阿片受体信号传导效力的分子开关

Bhowmik, Srijita; Galeta, Juraj; Havel, Václav; Nelson, Melissa; Faouzi, Abdelfattah; Bechand, Benjamin; Ansonoff, Mike; Fiala, Tomas; Hunkele, Amanda; Kruegel, Andrew C; Pintar, John E; Majumdar, Susruta; Javitch, Jonathan A; Sames, Dalibor

7-Hydroxymitragynine Is an Active Metabolite of Mitragynine and a Key Mediator of Its Analgesic Effects

7-羟基帽柱木碱是帽柱木碱的活性代谢产物,也是其镇痛作用的关键介质。

Kruegel, Andrew C; Uprety, Rajendra; Grinnell, Steven G; Langreck, Cory; Pekarskaya, Elizabeth A; Le Rouzic, Valerie; Ansonoff, Michael; Gassaway, Madalee M; Pintar, John E; Pasternak, Gavril W; Javitch, Jonathan A; Majumdar, Susruta; Sames, Dalibor

Opioids and opioid receptors orchestrate wound repair

阿片类物质和阿片受体协调伤口修复

Wang, Ying; Gupta, Mihir; Poonawala, Tasneem; Farooqui, Mariya; Li, Yunfang; Peng, Fei; Rao, Sheldon; Ansonoff, Michael; Pintar, John E; Gupta, Kalpna

Mexneurin is a novel precursor of peptides in the central nervous system of rodents

Mexneurin是啮齿动物中枢神经系统中一种新型肽类前体。

Matus-Ortega, Maura E; Leff Gelman, Philippe; Calva-Nieves, Juan C; Flores-Zamora, Anabel; Salazar-Juárez, Alberto; Torner-Aguilar, Carlos-Alejandro; Gamba, Gerardo; De Los Heros, Paola; Peng, Bonnie; Pintar, John E; Gompf, Heinrich S; Allen, Charles N; Antón-Palma, Benito

Preclinical findings predicting efficacy and side-effect profile of LY2940094, an antagonist of nociceptin receptors

预测LY2940094(一种伤害感受素受体拮抗剂)疗效和副作用的临床前研究结果

Witkin, Jeffrey M; Rorick-Kehn, Linda M; Benvenga, Mark J; Adams, Benjamin L; Gleason, Scott D; Knitowski, Karen M; Li, Xia; Chaney, Steven; Falcone, Julie F; Smith, Janice W; Foss, Julie; Lloyd, Kirsti; Catlow, John T; McKinzie, David L; Svensson, Kjell A; Barth, Vanessa N; Toledo, Miguel A; Diaz, Nuria; Lafuente, Celia; Jiménez, Alma; Benito, Alfonso; Pedregal, Conception; Martínez-Grau, Maria A; Post, Anke; Ansonoff, Michael A; Pintar, John E; Statnick, Michael A

The biology of Nociceptin/Orphanin FQ (N/OFQ) related to obesity, stress, anxiety, mood, and drug dependence

伤害感受素/孤啡肽FQ (N/OFQ) 的生物学特性与肥胖、压力、焦虑、情绪和药物依赖有关

Witkin, Jeffrey M; Statnick, Michael A; Rorick-Kehn, Linda M; Pintar, John E; Ansonoff, Michael; Chen, Yanyun; Tucker, R Craig; Ciccocioppo, Roberto

GPR171 is a hypothalamic G protein-coupled receptor for BigLEN, a neuropeptide involved in feeding

GPR171是下丘脑中一种G蛋白偶联受体,其受体为BigLEN,一种参与摄食的神经肽。

Gomes, Ivone; Aryal, Dipendra K; Wardman, Jonathan H; Gupta, Achla; Gagnidze, Khatuna; Rodriguiz, Ramona M; Kumar, Sanjai; Wetsel, William C; Pintar, John E; Fricker, Lloyd D; Devi, Lakshmi A

Neuropeptidomic analysis establishes a major role for prohormone convertase-2 in neuropeptide biosynthesis

神经肽组学分析证实了前激素转化酶-2在神经肽生物合成中发挥着重要作用。

Zhang, Xin; Pan, Hui; Peng, Bonnie; Steiner, Donald F; Pintar, John E; Fricker, Lloyd D

Potentiating effect of morphine on oral Salmonella enterica serovar Typhimurium infection is μ-opioid receptor-dependent

吗啡对口服鼠伤寒沙门氏菌感染的增强作用依赖于μ-阿片受体。

Breslow, Jessica M; Feng, Pu; Meissler, Joseph J; Pintar, John E; Gaughan, John; Adler, Martin W; Eisenstein, Toby K