日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Molecular and functional profiling unravels targetable vulnerabilities in colorectal cancer

分子和功能分析揭示结直肠癌的可靶向脆弱性

Vlachavas, Efstathios-Iason; Voutetakis, Konstantinos; Kosmidou, Vivian; Tsikalakis, Spyridon; Roditis, Spyridon; Pateas, Konstantinos; Kim, Ryangguk; Pagel, Kymberleigh; Wolf, Stephan; Warsow, Gregor; Dimitrakopoulou-Strauss, Antonia; Zografos, Georgios N; Pintzas, Alexander; Betge, Johannes; Papadodima, Olga; Wiemann, Stefan

DPS-2: A Novel Dual MEK/ERK and PI3K/AKT Pathway Inhibitor with Powerful Ex Vivo and In Vivo Anticancer Properties

DPS-2:一种新型双重 MEK/ERK 和 PI3K/AKT 通路抑制剂,具有强大的体外和体内抗癌特性

Maria Goulielmaki, Nikos Assimomytis, Jan Rozanc, Eleni Taki, Ioannis Christodoulou, Leonidas G Alexopoulos, Vassilis Zoumpourlis, Alexandros Pintzas, Demetris Papahatjis

Death receptor 5 (DR5) and a 5-gene apoptotic biomarker panel with significant differential diagnostic potential in colorectal cancer

死亡受体5 (DR5) 和5基因凋亡生物标志物组合在结直肠癌中具有显著的鉴别诊断潜力

Devetzi, Marina; Kosmidou, Vivian; Vlassi, Margarita; Perysinakis, Iraklis; Aggeli, Chrysanthi; Choreftaki, Theodosia; Zografos, Georgios N; Pintzas, Alexander

IAP antagonists Birinapant and AT-406 efficiently synergise with either TRAIL, BRAF, or BCL-2 inhibitors to sensitise BRAFV600E colorectal tumour cells to apoptosis

IAP 拮抗剂 Birinapant 和 AT-406 可与 TRAIL、BRAF 或 BCL-2 抑制剂有效协同作用,使 BRAFV600E 结直肠肿瘤细胞对凋亡敏感

Philippos Perimenis, Apostolos Galaris, Alexandra Voulgari, Margarita Prassa, Alexander Pintzas

BRAF associated autophagy exploitation: BRAF and autophagy inhibitors synergise to efficiently overcome resistance of BRAF mutant colorectal cancer cells

BRAF 相关自噬利用:BRAF 和自噬抑制剂协同作用,有效克服 BRAF 突变结肠直肠癌细胞的耐药性

Maria Goulielmaki, Evangelos Koustas, Eirini Moysidou, Margarita Vlassi, Takehiko Sasazuki, Senji Shirasawa, George Zografos, Eftychia Oikonomou, Alexander Pintzas

EZH2 regulates cofilin activity and colon cancer cell migration by targeting ITGA2 gene

EZH2通过靶向ITGA2基因调控肌动蛋白丝切活性和结肠癌细胞迁移

Angelo Ferraro, Themis Boni, Alexander Pintzas

BRAF and RAS oncogenes regulate Rho GTPase pathways to mediate migration and invasion properties in human colon cancer cells: a comparative study

BRAF 和 RAS 致癌基因调节 Rho GTPase 通路介导人类结肠癌细胞的迁移和侵袭特性:一项比较研究

Eleni Makrodouli, Eftychia Oikonomou, Michal Koc, Ladislav Andera, Takehiko Sasazuki, Senji Shirasawa, Alexander Pintzas

Selective BRAFV600E inhibitor PLX4720, requires TRAIL assistance to overcome oncogenic PIK3CA resistance

选择性BRAFV600E抑制剂PLX4720需要TRAIL的辅助才能克服致癌性PIK3CA耐药性。

Oikonomou, Eftychia; Koc, Michal; Sourkova, Vladimira; Andera, Ladislav; Pintzas, Alexander

The expression of ELK transcription factors in adult DRG: Novel isoforms, antisense transcripts and upregulation by nerve damage

ELK转录因子在成人背根神经节中的表达:新型亚型、反义转录本及神经损伤引起的上调

Kerr, Niall; Pintzas, Alexander; Holmes, Fiona; Hobson, Sally-Ann; Pope, Robert; Wallace, Mark; Wasylyk, Christine; Wasylyk, Bohdan; Wynick, David

BRAF(V600E) efficient transformation and induction of microsatellite instability versus KRAS(G12V) induction of senescence markers in human colon cancer cells

BRAF(V600E)有效转化和诱导微卫星不稳定性与 KRAS(G12V)诱导人类结肠癌细胞衰老标志物

Eftychia Oikonomou, Eleni Makrodouli, Maria Evagelidou, Tobias Joyce, Lesley Probert, Alexander Pintzas