日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Comparative Pharmacokinetics and Safety of Cannabidiol in a Powder Formulation, CBtru(®), vs an Oil-Based Formulation, Epidyolex(®), Under Fasted and Fed Conditions in Healthy Participants: A Randomized Open-Label Cross-Over Phase I Study

在健康受试者空腹和餐后状态下,比较粉剂型大麻二酚 (CBtru®) 与油剂型大麻二酚 (Epidyolex®) 的药代动力学和安全性:一项随机、开放标签、交叉 I 期研究

Bendik, Igor; Beck, Mareike; Manderna, Anu; Roos, Franz F; Wang, Jun; McCarthy, Deanna; Schweiggert, Christiane; Besheer, Ahmed; Baisley, Josh; Misic, Zdravka; Mussler, Bernd; Kuttenkeuler, Adam; Piomelli, Daniele; Péter, Szabolcs

Metabolic reallocation in spinal cord oligodendrocytes drives chronic pain via neuronal β-amyloid production

脊髓少突胶质细胞的代谢重分配通过神经元β-淀粉样蛋白的产生驱动慢性疼痛。

Fotio, Yannick; Al Masri, Saeed; Shi, Zechuan; Le, Johnny; Das, Sudeshna; Rubtsova, Varvara I; Mabou Tagne, Alex; Jang, Cholsoon; Swarup, Vivek; Piomelli, Daniele

A novel palmitoylethanolamide formulation improves hyperalgesia and red cell instability in murine sickle cell disease

新型棕榈酰乙醇胺制剂可改善小鼠镰状细胞病中的痛觉过敏和红细胞不稳定。

Argueta, Donovan A; Garcia, Natalie R; Mabou Tagne, Alex; Piomelli, Daniele; Gupta, Kalpna

Circulating glycerate predicts resilience to fructose-induced hepatic steatosis.

循环甘油酸盐可预测机体对果糖诱导的肝脂肪变性的抵抗力

Ramirez Cuauhtemoc B, Ahn In Sook, Rubtsova Varvara I, Cely Ingrid, Le Johnny, Kim Joohwan, Jung Sunhee, Kelly Miranda E, Kim Yeojin, Bae Hosung, Song Won-Suk, Alam Yasmine H, Zhang Guanglin, Diamante Graciel, Chao Alina, Hoffner Lauren, Anica Alexis, Le Izabelle, Lopez Miranda L, Tamburini Ian J, Moyer Elena M, Tsai Ariel, Yang Qin, Dai Xing, Piomelli Daniele, Lee Gina, Yang Xia, Jang Cholsoon

Neuroprotective, anti-inflammatory, and analgesic activity of palmitoylethanolamide in sickle cell mice.

棕榈酰乙醇胺对镰状细胞小鼠具有神经保护、抗炎和镇痛作用

Argueta Donovan A, Avalos Bryant, Goel Yugal, Tran Huy, Fotio Yannick, Piomelli Daniele, DiPatrizio Nicholas V, Gupta Kalpna

Chronic cannabis use in people with bipolar disorder is associated with comparable decision-making and functional outcome to healthy participants

双相情感障碍患者长期使用大麻与健康参与者相比,其决策能力和功能结果相当。

Miranda, Alannah; Roberts, Benjamin Z; Holloway, Breanna M; Peek, Elizabeth; Rosberg, Holden; Ayoub, Samantha M; Piomelli, Daniele; Jung, Kwang-Mook; Barnes, Samuel A; Rossi, Steven; Geyer, Mark A; Perry, William; Minassian, Arpi; Young, Jared W

Adolescent exposure to Δ9-tetrahydrocannabinol impairs testicular function in young adult male mice.

青少年时期接触 α9-四氢大麻酚会损害年轻成年雄性小鼠的睾丸功能。

Lim Jinhwan, Quach Caitlin, Nguyen Julie, Rizk Andrew, Getze Samantha, Jung Kwang-Mook, Mahler Stephen V, Piomelli Daniele, Luderer Ulrike

Microglia Support Both the Singular Form of LTP Expressed by the Lateral Perforant Path and Episodic Memory.

小胶质细胞支持由外侧穿通通路表达的单一形式的长时程增强(LTP)和情景记忆

Chavez Jasmine, Le Aliza A, Quintanilla Julian, Lauterborn Julie C, Jia Yousheng, Tagne Alex Mabou, Lee Hye-Lim, Jung Kwang-Mook, Piomelli Daniele, Lynch Gary, Gall Christine M

Association of Serum Endocannabinoid Levels with Pancreatitis and Pancreatitis-Related Pain

血清内源性大麻素水平与胰腺炎及胰腺炎相关疼痛的关系

Goodman, Marc T; Lombardi, Christina; Torrens, Alexa; Bresee, Catherine; Saloman, Jami L; Li, Liang; Yang, Yunlong; Fisher, William E; Fogel, Evan L; Forsmark, Christopher E; Conwell, Darwin L; Hart, Phil A; Park, Walter G; Topazian, Mark; Vege, Santhi S; Van Den Eeden, Stephen K; Bellin, Melena D; Andersen, Dana K; Serrano, Jose; Yadav, Dhiraj; Pandol, Stephen J; Piomelli, Daniele

NAAA-regulated lipid signaling in monocytes controls the induction of hyperalgesic priming in mice

单核细胞中NAAA调控的脂质信号传导控制着小鼠痛觉过敏的启动。

Yannick Fotio ,Alex Mabou Tagne # ,Erica Squire # ,Hye-Lim Lee ,Connor M Phillips ,Kayla Chang ,Faizy Ahmed ,Andrew S Greenberg ,S Armando Villalta ,Vanessa M Scarfone ,Gilberto Spadoni ,Marco Mor ,Daniele Piomelli