HPV16 E6 induces chromosomal instability due to polar chromosomes caused by E6AP-dependent degradation of the mitotic kinesin CENP-E
HPV16 E6 会因 E6AP 依赖的有丝分裂驱动蛋白 CENP-E 降解而导致极性染色体,进而引发染色体不稳定性
期刊:Proceedings of the National Academy of Sciences of the United States of America
影响因子:
doi:10.1073/pnas.2216700120
Pippa F Cosper, Laura C F Hrycyniak, Maha Paracha, Denis L Lee, Jun Wan, Kathryn Jones, Sophie A Bice, Kwangok Nickel, Samyukta Mallick, Alison M Taylor, Randall J Kimple, Paul F Lambert, Beth A Weaver